The status of studies on the mechanism of microcirculatory dysfunction in the process of diabetic kidney injury
Abstract Diabetic nephropathy (DN) is one of the most common and serious microvascular complications of diabetes mellitus (DM) and is the main cause of end-stage renal disease. Endothelial dysfunction caused by persistent hyperglycemia occurs at the initial stage of vascular disease. Moreover, persi...
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| Format: | Article |
| Language: | English |
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BMC
2025-05-01
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| Series: | Diabetology & Metabolic Syndrome |
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| Online Access: | https://doi.org/10.1186/s13098-025-01718-4 |
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| author | Zeng Wu Yu Gao Chun-yue Zuo Xiao-rong Wang Xiao-han Chen Xiao-hong Zhou Wei-juan Gao |
| author_facet | Zeng Wu Yu Gao Chun-yue Zuo Xiao-rong Wang Xiao-han Chen Xiao-hong Zhou Wei-juan Gao |
| author_sort | Zeng Wu |
| collection | DOAJ |
| description | Abstract Diabetic nephropathy (DN) is one of the most common and serious microvascular complications of diabetes mellitus (DM) and is the main cause of end-stage renal disease. Endothelial dysfunction caused by persistent hyperglycemia occurs at the initial stage of vascular disease. Moreover, persistent hyperglycemia is also a critical factor causing renal microcirculatory dysfunction. In recent years, many studies have confirmed that chronic hypoxia caused by microcirculatory dysfunction is one of the main mechanisms of kidney injury in patients with DM. Similarly, microcirculatory dysfunction damages renal tissue through interactions with other pathophysiological processes, thereby promoting the occurrence and development of DN. Thus, this article reviews the pathogenesis of renal microcirculatory dysfunction in DM and its interaction with stress, energy metabolism, and immunologic inflammation. Furthermore, a new idea was proposed to analyze the mechanism of kidney injury in DM from the perspective of microcirculatory dysfunction. |
| format | Article |
| id | doaj-art-bac2c11df76341ccb93de69aa11a12d8 |
| institution | OA Journals |
| issn | 1758-5996 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj-art-bac2c11df76341ccb93de69aa11a12d82025-08-20T02:25:17ZengBMCDiabetology & Metabolic Syndrome1758-59962025-05-0117111510.1186/s13098-025-01718-4The status of studies on the mechanism of microcirculatory dysfunction in the process of diabetic kidney injuryZeng Wu0Yu Gao1Chun-yue Zuo2Xiao-rong Wang3Xiao-han Chen4Xiao-hong Zhou5Wei-juan Gao6Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Hebei University of Chinese MedicineHebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Hebei University of Chinese MedicineHebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Hebei University of Chinese MedicineHebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Hebei University of Chinese MedicineHebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Hebei University of Chinese MedicineHebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Hebei University of Chinese MedicineHebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Hebei University of Chinese MedicineAbstract Diabetic nephropathy (DN) is one of the most common and serious microvascular complications of diabetes mellitus (DM) and is the main cause of end-stage renal disease. Endothelial dysfunction caused by persistent hyperglycemia occurs at the initial stage of vascular disease. Moreover, persistent hyperglycemia is also a critical factor causing renal microcirculatory dysfunction. In recent years, many studies have confirmed that chronic hypoxia caused by microcirculatory dysfunction is one of the main mechanisms of kidney injury in patients with DM. Similarly, microcirculatory dysfunction damages renal tissue through interactions with other pathophysiological processes, thereby promoting the occurrence and development of DN. Thus, this article reviews the pathogenesis of renal microcirculatory dysfunction in DM and its interaction with stress, energy metabolism, and immunologic inflammation. Furthermore, a new idea was proposed to analyze the mechanism of kidney injury in DM from the perspective of microcirculatory dysfunction.https://doi.org/10.1186/s13098-025-01718-4Diabetic nephropathyMicrocirculationEndothelial dysfunctionRenal hypoxiaInflammation |
| spellingShingle | Zeng Wu Yu Gao Chun-yue Zuo Xiao-rong Wang Xiao-han Chen Xiao-hong Zhou Wei-juan Gao The status of studies on the mechanism of microcirculatory dysfunction in the process of diabetic kidney injury Diabetology & Metabolic Syndrome Diabetic nephropathy Microcirculation Endothelial dysfunction Renal hypoxia Inflammation |
| title | The status of studies on the mechanism of microcirculatory dysfunction in the process of diabetic kidney injury |
| title_full | The status of studies on the mechanism of microcirculatory dysfunction in the process of diabetic kidney injury |
| title_fullStr | The status of studies on the mechanism of microcirculatory dysfunction in the process of diabetic kidney injury |
| title_full_unstemmed | The status of studies on the mechanism of microcirculatory dysfunction in the process of diabetic kidney injury |
| title_short | The status of studies on the mechanism of microcirculatory dysfunction in the process of diabetic kidney injury |
| title_sort | status of studies on the mechanism of microcirculatory dysfunction in the process of diabetic kidney injury |
| topic | Diabetic nephropathy Microcirculation Endothelial dysfunction Renal hypoxia Inflammation |
| url | https://doi.org/10.1186/s13098-025-01718-4 |
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