HBeAg testing is better than quantitative HBsAg assay as an alternative to HBV DNA assay among HBV-infected pregnant women
Introduction: Using tenofovir disoproxil fumarate (TDF) is recommended in the 3rd trimester for pregnant women with HBV DNA ≥ 200,000 IU/mL to prevent mother-to-child transmission (MTCT) of hepatitis B virus (HBV). However, HBV DNA quantification is unavailable in many resource-limited areas worldw...
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The Journal of Infection in Developing Countries
2023-10-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/17516 |
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| author | Minh Ngoc Nguyen Thi Thu Huong Nguyen Tran Dieu Hien Pham Van Nghia Khuu Quoc Cuong Hoang Vu Thuong Nguyen Ngoc Huu Tran |
| author_facet | Minh Ngoc Nguyen Thi Thu Huong Nguyen Tran Dieu Hien Pham Van Nghia Khuu Quoc Cuong Hoang Vu Thuong Nguyen Ngoc Huu Tran |
| author_sort | Minh Ngoc Nguyen |
| collection | DOAJ |
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Introduction: Using tenofovir disoproxil fumarate (TDF) is recommended in the 3rd trimester for pregnant women with HBV DNA ≥ 200,000 IU/mL to prevent mother-to-child transmission (MTCT) of hepatitis B virus (HBV). However, HBV DNA quantification is unavailable in many resource-limited areas worldwide, hence prophylaxis is often missed. The aim of this study was to determine whether HBeAg or qHBsAg is a better alternative to HBV DNA testing in HBV-infected pregnant women.
Methodology: In this prospective cohort study, pregnant women with HBV infection were recruited in 3 hospitals from October 2019 to November 2020. Socio-demographic and clinical data were collected. Blood samples were taken for qHBsAg and HBV DNA testing. HBeAg results were collected from the medical records of the participants who visited a doctor during the study.
Results: 465 pregnant women met the study criteria. 41.9% were HBeAg positive, 33.3% had high qHBsAg levels (> 104 IU/mL), 38.3% had high HBV DNA levels (≥ 200,000 IU/mL). Pregnant women with high qHBsAg levels were 27 times more likely to have high HBV DNA levels (aOR = 27.0, 95% CI: 11.1-65.5, p < 0.001). Participants who were HBeAg positive were 57.5 times more likely to have high HBV DNA levels (aOR = 57.5, 95% CI: 23.0-140.0, p < 0.001). The sensitivity of qHBsAg and HBeAg was 80% and 94%, respectively; and specificity was 95% and 90%, respectively.
Conclusions: HBeAg testing should be considered over qHBsAg assay as an alternative to HBV DNA assay because of its technical simplicity, lower cost, and fewer missed treatments.
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| format | Article |
| id | doaj-art-bac13e5ebc844fa9bc3c4c15e9f90c67 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2023-10-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-bac13e5ebc844fa9bc3c4c15e9f90c672025-08-20T02:14:16ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802023-10-01171010.3855/jidc.17516HBeAg testing is better than quantitative HBsAg assay as an alternative to HBV DNA assay among HBV-infected pregnant womenMinh Ngoc Nguyen0Thi Thu Huong Nguyen1Tran Dieu Hien Pham2Van Nghia Khuu3Quoc Cuong Hoang4Vu Thuong Nguyen5Ngoc Huu Tran6Pasteur Institute in Ho Chi Minh City, VietnamPasteur Institute in Ho Chi Minh City, VietnamUniversity of Medicine Pham Ngoc Thach, Ho Chi Minh City, VietnamPasteur Institute in Ho Chi Minh City, VietnamCan Tho Department of Health, VietnamPasteur Institute in Ho Chi Minh City, VietnamPasteur Institute in Ho Chi Minh City, Vietnam Introduction: Using tenofovir disoproxil fumarate (TDF) is recommended in the 3rd trimester for pregnant women with HBV DNA ≥ 200,000 IU/mL to prevent mother-to-child transmission (MTCT) of hepatitis B virus (HBV). However, HBV DNA quantification is unavailable in many resource-limited areas worldwide, hence prophylaxis is often missed. The aim of this study was to determine whether HBeAg or qHBsAg is a better alternative to HBV DNA testing in HBV-infected pregnant women. Methodology: In this prospective cohort study, pregnant women with HBV infection were recruited in 3 hospitals from October 2019 to November 2020. Socio-demographic and clinical data were collected. Blood samples were taken for qHBsAg and HBV DNA testing. HBeAg results were collected from the medical records of the participants who visited a doctor during the study. Results: 465 pregnant women met the study criteria. 41.9% were HBeAg positive, 33.3% had high qHBsAg levels (> 104 IU/mL), 38.3% had high HBV DNA levels (≥ 200,000 IU/mL). Pregnant women with high qHBsAg levels were 27 times more likely to have high HBV DNA levels (aOR = 27.0, 95% CI: 11.1-65.5, p < 0.001). Participants who were HBeAg positive were 57.5 times more likely to have high HBV DNA levels (aOR = 57.5, 95% CI: 23.0-140.0, p < 0.001). The sensitivity of qHBsAg and HBeAg was 80% and 94%, respectively; and specificity was 95% and 90%, respectively. Conclusions: HBeAg testing should be considered over qHBsAg assay as an alternative to HBV DNA assay because of its technical simplicity, lower cost, and fewer missed treatments. https://jidc.org/index.php/journal/article/view/17516HBVMTCTpregnantHBeAgqHBsAgHBVDNA |
| spellingShingle | Minh Ngoc Nguyen Thi Thu Huong Nguyen Tran Dieu Hien Pham Van Nghia Khuu Quoc Cuong Hoang Vu Thuong Nguyen Ngoc Huu Tran HBeAg testing is better than quantitative HBsAg assay as an alternative to HBV DNA assay among HBV-infected pregnant women Journal of Infection in Developing Countries HBV MTCT pregnant HBeAg qHBsAg HBVDNA |
| title | HBeAg testing is better than quantitative HBsAg assay as an alternative to HBV DNA assay among HBV-infected pregnant women |
| title_full | HBeAg testing is better than quantitative HBsAg assay as an alternative to HBV DNA assay among HBV-infected pregnant women |
| title_fullStr | HBeAg testing is better than quantitative HBsAg assay as an alternative to HBV DNA assay among HBV-infected pregnant women |
| title_full_unstemmed | HBeAg testing is better than quantitative HBsAg assay as an alternative to HBV DNA assay among HBV-infected pregnant women |
| title_short | HBeAg testing is better than quantitative HBsAg assay as an alternative to HBV DNA assay among HBV-infected pregnant women |
| title_sort | hbeag testing is better than quantitative hbsag assay as an alternative to hbv dna assay among hbv infected pregnant women |
| topic | HBV MTCT pregnant HBeAg qHBsAg HBVDNA |
| url | https://jidc.org/index.php/journal/article/view/17516 |
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