Two case reports of rare cocaine-associated dermatoses: Pyoderma gangrenosum and linear IgA bullous dermatosis

We report two cases of cocaine-associated dermatoses: pyoderma gangrenosum and linear IgA bullous dermatosis. These cases highlight the importance of considering less common associations with drug use in the development of certain dermatoses. Eliciting a good history around the onset of the skin con...

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Main Authors: Daniela Cino, Barbara Marzario, Sophia Colantonio, Mark G. Kirchhof
Format: Article
Language:English
Published: SAGE Publishing 2025-06-01
Series:SAGE Open Medical Case Reports
Online Access:https://doi.org/10.1177/2050313X251350333
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author Daniela Cino
Barbara Marzario
Sophia Colantonio
Mark G. Kirchhof
author_facet Daniela Cino
Barbara Marzario
Sophia Colantonio
Mark G. Kirchhof
author_sort Daniela Cino
collection DOAJ
description We report two cases of cocaine-associated dermatoses: pyoderma gangrenosum and linear IgA bullous dermatosis. These cases highlight the importance of considering less common associations with drug use in the development of certain dermatoses. Eliciting a good history around the onset of the skin condition and potential triggers is vital in establishing a causal link. In both of our cases, the lesions improved with cocaine avoidance and disease-specific treatment. Use of cocaine is most commonly associated with vasculitis, but has been reported to trigger neutrophilic dermatoses and vesiculobullous diseases. Dermatologists need to be aware of these less common cocaine-associated dermatoses, particularly when patients are not responding to standard therapy alone.
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publishDate 2025-06-01
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record_format Article
series SAGE Open Medical Case Reports
spelling doaj-art-bab9772ccb3849df97fdce5b3f2f6d2d2025-08-20T02:36:31ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2025-06-011310.1177/2050313X251350333Two case reports of rare cocaine-associated dermatoses: Pyoderma gangrenosum and linear IgA bullous dermatosisDaniela Cino0Barbara Marzario1Sophia Colantonio2Mark G. Kirchhof3The Ottawa Hospital, ON, CanadaThe Ottawa Hospital, ON, CanadaThe Ottawa Hospital, ON, CanadaThe Ottawa Hospital, ON, CanadaWe report two cases of cocaine-associated dermatoses: pyoderma gangrenosum and linear IgA bullous dermatosis. These cases highlight the importance of considering less common associations with drug use in the development of certain dermatoses. Eliciting a good history around the onset of the skin condition and potential triggers is vital in establishing a causal link. In both of our cases, the lesions improved with cocaine avoidance and disease-specific treatment. Use of cocaine is most commonly associated with vasculitis, but has been reported to trigger neutrophilic dermatoses and vesiculobullous diseases. Dermatologists need to be aware of these less common cocaine-associated dermatoses, particularly when patients are not responding to standard therapy alone.https://doi.org/10.1177/2050313X251350333
spellingShingle Daniela Cino
Barbara Marzario
Sophia Colantonio
Mark G. Kirchhof
Two case reports of rare cocaine-associated dermatoses: Pyoderma gangrenosum and linear IgA bullous dermatosis
SAGE Open Medical Case Reports
title Two case reports of rare cocaine-associated dermatoses: Pyoderma gangrenosum and linear IgA bullous dermatosis
title_full Two case reports of rare cocaine-associated dermatoses: Pyoderma gangrenosum and linear IgA bullous dermatosis
title_fullStr Two case reports of rare cocaine-associated dermatoses: Pyoderma gangrenosum and linear IgA bullous dermatosis
title_full_unstemmed Two case reports of rare cocaine-associated dermatoses: Pyoderma gangrenosum and linear IgA bullous dermatosis
title_short Two case reports of rare cocaine-associated dermatoses: Pyoderma gangrenosum and linear IgA bullous dermatosis
title_sort two case reports of rare cocaine associated dermatoses pyoderma gangrenosum and linear iga bullous dermatosis
url https://doi.org/10.1177/2050313X251350333
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