2D Flower-like CdS@Co/Mo-MOF as Co-Reaction Accelerator of g-C<sub>3</sub>N<sub>4</sub>-Based Electrochemiluminescence Sensor for Chlorpromazine Hydrochloride
In this study, we have proposed an electrochemiluminescence (ECL) signal amplification system which is based on two-dimensional (2D) flower-like CdS@Co/Mo-MOF composites as a co-reaction accelerator of the g-C<sub>3</sub>N<sub>4</sub>/S<sub>2</sub>O<sub>8<...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/14/12/586 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | In this study, we have proposed an electrochemiluminescence (ECL) signal amplification system which is based on two-dimensional (2D) flower-like CdS@Co/Mo-MOF composites as a co-reaction accelerator of the g-C<sub>3</sub>N<sub>4</sub>/S<sub>2</sub>O<sub>8</sub><sup>2−</sup> system for ultrasensitive detection of chlorpromazine hydrochloride (CPH). Specifically, the 2D flower-like Co/Mo-MOF with mesoporous alleviated the aggregation of CdS NPs while simultaneously fostering reactant-active site contact and improving the reactant–product transport rate. This allowed the material to act as a novel co-reaction accelerator, speeding up the transformation of the S<sub>2</sub>O<sub>8</sub><sup>2−</sup> into SO<sub>4</sub><sup>•−</sup> and enhancing the cathodic ECL emission of g-C<sub>3</sub>N<sub>4</sub>. Moreover, the signal probe which was synthesized by coupling the 2D CdS@Co/Mo-MOF and graphitic carbon nitride (g-C<sub>3</sub>N<sub>4</sub>) achieved the generation of SO<sub>4</sub><sup>•−</sup> in situ and reduced energy loss. The results confirmed that the ECL signal was enhanced 6.2-fold and stabilized by CdS@Co/Mo-MOF. Based on the extremely strong quenching effect of chlorpromazine hydrochloride (CPH) on this system, a “signal-off” type sensor was constructed. The sensor demonstrated excellent sensitivity and linear response to CPH concentrations ranging from 1 pmol L<sup>−1</sup> to 100 μmol L<sup>−1</sup>, with a low detection limit of 0.4 pmol L<sup>−1</sup> (S/N = 3). |
|---|---|
| ISSN: | 2079-6374 |