Physical activity in the relationship between multiple air pollutants exposure and risk of hypertension: a prospective cohort study in China
Abstract This study is targeted to explore the relationship between exposure to various air pollutants (PM1, PM2.5, PM10, O3, and NO2) and hypertension risk, and to assess the role of physical activity in this relationship among Chinese adults. The association between multiple ambient air pollutants...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-09341-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849766548447690752 |
|---|---|
| author | Yuquan Chen Yanwei You Jiarong He Yuechuan Zhang Qi Zhang Fan Yang Mingming Zhang |
| author_facet | Yuquan Chen Yanwei You Jiarong He Yuechuan Zhang Qi Zhang Fan Yang Mingming Zhang |
| author_sort | Yuquan Chen |
| collection | DOAJ |
| description | Abstract This study is targeted to explore the relationship between exposure to various air pollutants (PM1, PM2.5, PM10, O3, and NO2) and hypertension risk, and to assess the role of physical activity in this relationship among Chinese adults. The association between multiple ambient air pollutants (with separate models for each pollutant) and hypertension was explored using time-varying Cox proportional hazards regression models, adjusted for season, spatial autocorrelation, demographic, socioeconomic, and behavioral factors. The median follow-up was 4 years. The interaction tests revealed significant interactions between physical activity and exposure to PM1, PM2.5, PM10, and NO2, but not for O3 (P > 0.05). Physically active participants did not show significant increases in hypertension risk from pollutants. In contrast, inactive participants faced higher risks: PM1 (12.9%), PM2.5 (6.0%), PM10 (5.0%), NO2 (17.0%). Finally, in the multiple pollutant models, controlling for NO2 nullified the significance of PM1 and PM2.5, while adjusting for O3 increased their HRs. PM10 and O3 remained significant in all models, and adjusting for PM10 or both PM10 and O3 eliminated the significance of NO2. Higher concentrations of air pollution were linked to a heightened risk of developing hypertension among Chinese adults; however, physical activity may help mitigate this elevated risk. |
| format | Article |
| id | doaj-art-bab321b154154ec0aad2d9afc4f9eefd |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-bab321b154154ec0aad2d9afc4f9eefd2025-08-20T03:04:33ZengNature PortfolioScientific Reports2045-23222025-07-0115111310.1038/s41598-025-09341-zPhysical activity in the relationship between multiple air pollutants exposure and risk of hypertension: a prospective cohort study in ChinaYuquan Chen0Yanwei You1Jiarong He2Yuechuan Zhang3Qi Zhang4Fan Yang5Mingming Zhang6School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing & Health Sciences, Monash UniversityDivision of Sports Science & Physical Education, Tsinghua UniversityDepartment of Neurosurgery, The Second Xiangya Hospital, Central South UniversityDepartment of Orthopedics, Peking Union Medical College HospitalTaishan UniversitySchool of Public Health and Preventive Medicine, Faculty of Medicine, Nursing & Health Sciences, Monash UniversityDepartment of Neurosurgery, The Second Xiangya Hospital, Central South UniversityAbstract This study is targeted to explore the relationship between exposure to various air pollutants (PM1, PM2.5, PM10, O3, and NO2) and hypertension risk, and to assess the role of physical activity in this relationship among Chinese adults. The association between multiple ambient air pollutants (with separate models for each pollutant) and hypertension was explored using time-varying Cox proportional hazards regression models, adjusted for season, spatial autocorrelation, demographic, socioeconomic, and behavioral factors. The median follow-up was 4 years. The interaction tests revealed significant interactions between physical activity and exposure to PM1, PM2.5, PM10, and NO2, but not for O3 (P > 0.05). Physically active participants did not show significant increases in hypertension risk from pollutants. In contrast, inactive participants faced higher risks: PM1 (12.9%), PM2.5 (6.0%), PM10 (5.0%), NO2 (17.0%). Finally, in the multiple pollutant models, controlling for NO2 nullified the significance of PM1 and PM2.5, while adjusting for O3 increased their HRs. PM10 and O3 remained significant in all models, and adjusting for PM10 or both PM10 and O3 eliminated the significance of NO2. Higher concentrations of air pollution were linked to a heightened risk of developing hypertension among Chinese adults; however, physical activity may help mitigate this elevated risk.https://doi.org/10.1038/s41598-025-09341-zAir pollutantsHypertensionPhysical activityChina |
| spellingShingle | Yuquan Chen Yanwei You Jiarong He Yuechuan Zhang Qi Zhang Fan Yang Mingming Zhang Physical activity in the relationship between multiple air pollutants exposure and risk of hypertension: a prospective cohort study in China Scientific Reports Air pollutants Hypertension Physical activity China |
| title | Physical activity in the relationship between multiple air pollutants exposure and risk of hypertension: a prospective cohort study in China |
| title_full | Physical activity in the relationship between multiple air pollutants exposure and risk of hypertension: a prospective cohort study in China |
| title_fullStr | Physical activity in the relationship between multiple air pollutants exposure and risk of hypertension: a prospective cohort study in China |
| title_full_unstemmed | Physical activity in the relationship between multiple air pollutants exposure and risk of hypertension: a prospective cohort study in China |
| title_short | Physical activity in the relationship between multiple air pollutants exposure and risk of hypertension: a prospective cohort study in China |
| title_sort | physical activity in the relationship between multiple air pollutants exposure and risk of hypertension a prospective cohort study in china |
| topic | Air pollutants Hypertension Physical activity China |
| url | https://doi.org/10.1038/s41598-025-09341-z |
| work_keys_str_mv | AT yuquanchen physicalactivityintherelationshipbetweenmultipleairpollutantsexposureandriskofhypertensionaprospectivecohortstudyinchina AT yanweiyou physicalactivityintherelationshipbetweenmultipleairpollutantsexposureandriskofhypertensionaprospectivecohortstudyinchina AT jiaronghe physicalactivityintherelationshipbetweenmultipleairpollutantsexposureandriskofhypertensionaprospectivecohortstudyinchina AT yuechuanzhang physicalactivityintherelationshipbetweenmultipleairpollutantsexposureandriskofhypertensionaprospectivecohortstudyinchina AT qizhang physicalactivityintherelationshipbetweenmultipleairpollutantsexposureandriskofhypertensionaprospectivecohortstudyinchina AT fanyang physicalactivityintherelationshipbetweenmultipleairpollutantsexposureandriskofhypertensionaprospectivecohortstudyinchina AT mingmingzhang physicalactivityintherelationshipbetweenmultipleairpollutantsexposureandriskofhypertensionaprospectivecohortstudyinchina |