Physical and chemical niche of human growth plate for polarized bone development

Physical and chemical niche of human growth plate for polarized bone development

Abstract Growth plate (GP), a critical cartilaginous structure in amniotes, underpins longitudinal bone growth, yet the intricate mechanisms behind its polarized mineralization during evolution remain unclear. Herein, employing high-resolution analytical techniques, we reveal that the GP-epiphysis i...

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Main Authors: Chang Xie, Wenyue Li, Xudong Yao, Boxuan Wu, Jinghua Fang, Renwei Mao, Yiyang Yan, Hongxu Meng, Yan Wu, Xianzhu Zhang, Rui Li, Jie Zhang, Wangping Duan, Xuesong Dai, Xiaozhao Wang, Hongwei Ouyang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62711-z
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