NIR-II photo-accelerated polymer nanoparticles boost tumor immunotherapy via PD-L1 silencing and immunogenic cell death

NIR-II photo-accelerated polymer nanoparticles boost tumor immunotherapy via PD-L1 silencing and immunogenic cell death

Immune checkpoint blockade (ICB) therapy is a widely favored anti-tumor treatment, but it shows limited response to non-immunogenic “cold” tumors and suffers from drug resistance. Photodynamic therapy (PDT), as a powerful localized treatment approach, can convert a “cold tumor” into a “hot tumor” by...

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Bibliographic Details
Main Authors: Tian Zhang, Dongsheng Tang, Pengfei Wu, Shaoping Jiang, Yuquan Zhang, Abid Naeem, Yong Li, Chunhui Li, Bo Hu, Shuai Guo, Caixia Sun, Haihua Xiao, Ran Yan, Yuhua Weng, Yuanyu Huang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-04-01
Series:Bioactive Materials
Subjects:
siRNA
Polymer nanoparticles
PD-L1 silencing
Photodynamic therapy
Immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X24005553
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