Mycobacterium bovis infected domestic cats in an officially bovine tuberculosis free country resulting in human infection
Although the Netherlands is an officially bovine tuberculosis (bTB) free (OTF) country, sporadic infections with Mycobacterium bovis still cause tuberculosis (TB) in (non-bovine) mammals, including humans. We describe for the first time cases of M. bovis infection in domestic cats in the Netherlands...
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| Language: | English |
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Elsevier
2025-06-01
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| Series: | One Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352771425000849 |
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| author | Susanna Commandeur Marleen van der Most Jeroen Koomen Lucien van Keulen Annemieke Dinkla Xander Luinenburg Marieke Escher Pieter Jacobs Ingrid Keur Guy C.M. Grinwis Erik Weerts Els M. Broens Richard Anthony Miranda Kamst-van Agterveld Karin Rebel Erik Huisman Marloes Heijne Ad Koets |
| author_facet | Susanna Commandeur Marleen van der Most Jeroen Koomen Lucien van Keulen Annemieke Dinkla Xander Luinenburg Marieke Escher Pieter Jacobs Ingrid Keur Guy C.M. Grinwis Erik Weerts Els M. Broens Richard Anthony Miranda Kamst-van Agterveld Karin Rebel Erik Huisman Marloes Heijne Ad Koets |
| author_sort | Susanna Commandeur |
| collection | DOAJ |
| description | Although the Netherlands is an officially bovine tuberculosis (bTB) free (OTF) country, sporadic infections with Mycobacterium bovis still cause tuberculosis (TB) in (non-bovine) mammals, including humans. We describe for the first time cases of M. bovis infection in domestic cats in the Netherlands with transmission between companion animals and humans.In January 2023, a domestic cat, euthanized due to severe respiratory clinical signs, was diagnosed with M. bovis. Subsequently, three other cats from the household were euthanized and also diagnosed with M. bovis. The remaining kitten and dog received antibiotic treatment. Human contacts were screened using Tuberculin Skin Test (TST) and Interferon-Gamma Release Assay (IGRA). Lung lesions were detected in a TST+/IGRA− contact which tested positive for M. bovis DNA. This human lung-derived M. bovis DNA contained single nucleotide polymorphisms (SNPs) that were also identified in the DNA of M. bovis isolated from the cats in this household, strengthening the hypothesis of intra-species M. bovis transmission within the household. The four TST+ human contacts received antibiotic treatment. In the same period, another domestic cat from an unrelated household was euthanized due to respiratory clinical signs and diagnosed with M. bovis. This M. bovis strain differed 500 SNPs from the strains of the first household and was therefore genetically distinct. Commercially available, ready-to-use raw pet food was a suspected source in both households, however this could not be confirmed.These cases illustrate the need for one-health vigilance among both veterinarians and human physicians as essential to control outbreaks and prevent further spread to humans, companion animals, wildlife and livestock. |
| format | Article |
| id | doaj-art-baaa9a2e60714b60ad06c1e31387dcd4 |
| institution | OA Journals |
| issn | 2352-7714 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | One Health |
| spelling | doaj-art-baaa9a2e60714b60ad06c1e31387dcd42025-08-20T02:36:02ZengElsevierOne Health2352-77142025-06-012010104810.1016/j.onehlt.2025.101048Mycobacterium bovis infected domestic cats in an officially bovine tuberculosis free country resulting in human infectionSusanna Commandeur0Marleen van der Most1Jeroen Koomen2Lucien van Keulen3Annemieke Dinkla4Xander Luinenburg5Marieke Escher6Pieter Jacobs7Ingrid Keur8Guy C.M. Grinwis9Erik Weerts10Els M. Broens11Richard Anthony12Miranda Kamst-van Agterveld13Karin Rebel14Erik Huisman15Marloes Heijne16Ad Koets17Department of Bacteriology, Host Pathogen Interaction and Diagnostics Development, Wageningen Bioveterinary Research (WBVR), Wageningen University & Research, 8221 RA Lelystad, the Netherlands; Corresponding author.Department of Bacteriology, Host Pathogen Interaction and Diagnostics Development, Wageningen Bioveterinary Research (WBVR), Wageningen University & Research, 8221 RA Lelystad, the NetherlandsDepartment of Bacteriology, Host Pathogen Interaction and Diagnostics Development, Wageningen Bioveterinary Research (WBVR), Wageningen University & Research, 8221 RA Lelystad, the NetherlandsDepartment of Bacteriology, Host Pathogen Interaction and Diagnostics Development, Wageningen Bioveterinary Research (WBVR), Wageningen University & Research, 8221 RA Lelystad, the NetherlandsDepartment of Bacteriology, Host Pathogen Interaction and Diagnostics Development, Wageningen Bioveterinary Research (WBVR), Wageningen University & Research, 8221 RA Lelystad, the NetherlandsDepartment of Bacteriology, Host Pathogen Interaction and Diagnostics Development, Wageningen Bioveterinary Research (WBVR), Wageningen University & Research, 8221 RA Lelystad, the NetherlandsDepartment of Bacteriology, Host Pathogen Interaction and Diagnostics Development, Wageningen Bioveterinary Research (WBVR), Wageningen University & Research, 8221 RA Lelystad, the NetherlandsNetherlands Food and Consumer Product Safety Authority (NVWA), P.O. Box 43006, 3540 AA Utrecht, the NetherlandsNetherlands Food and Consumer Product Safety Authority (NVWA), P.O. Box 43006, 3540 AA Utrecht, the NetherlandsDepartment of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the NetherlandsDepartment of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the NetherlandsDepartment of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the NetherlandsNational Tuberculosis Reference Laboratory, Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), 3721 BA Bilthoven, the NetherlandsNational Tuberculosis Reference Laboratory, Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), 3721 BA Bilthoven, the NetherlandsMunicipal Health Service (GGD), Department of TB control, 3706 BR Utrecht, the NetherlandsMunicipal Health Service (GGD), Department of TB control, 7200 AA Zutphen, the NetherlandsDepartment of Bacteriology, Host Pathogen Interaction and Diagnostics Development, Wageningen Bioveterinary Research (WBVR), Wageningen University & Research, 8221 RA Lelystad, the NetherlandsDepartment of Bacteriology, Host Pathogen Interaction and Diagnostics Development, Wageningen Bioveterinary Research (WBVR), Wageningen University & Research, 8221 RA Lelystad, the NetherlandsAlthough the Netherlands is an officially bovine tuberculosis (bTB) free (OTF) country, sporadic infections with Mycobacterium bovis still cause tuberculosis (TB) in (non-bovine) mammals, including humans. We describe for the first time cases of M. bovis infection in domestic cats in the Netherlands with transmission between companion animals and humans.In January 2023, a domestic cat, euthanized due to severe respiratory clinical signs, was diagnosed with M. bovis. Subsequently, three other cats from the household were euthanized and also diagnosed with M. bovis. The remaining kitten and dog received antibiotic treatment. Human contacts were screened using Tuberculin Skin Test (TST) and Interferon-Gamma Release Assay (IGRA). Lung lesions were detected in a TST+/IGRA− contact which tested positive for M. bovis DNA. This human lung-derived M. bovis DNA contained single nucleotide polymorphisms (SNPs) that were also identified in the DNA of M. bovis isolated from the cats in this household, strengthening the hypothesis of intra-species M. bovis transmission within the household. The four TST+ human contacts received antibiotic treatment. In the same period, another domestic cat from an unrelated household was euthanized due to respiratory clinical signs and diagnosed with M. bovis. This M. bovis strain differed 500 SNPs from the strains of the first household and was therefore genetically distinct. Commercially available, ready-to-use raw pet food was a suspected source in both households, however this could not be confirmed.These cases illustrate the need for one-health vigilance among both veterinarians and human physicians as essential to control outbreaks and prevent further spread to humans, companion animals, wildlife and livestock.http://www.sciencedirect.com/science/article/pii/S2352771425000849Feline tuberculosisMycobacterium bovisZoonosisHuman transmissionOfficially bTB free (OTF) countryThe Netherlands |
| spellingShingle | Susanna Commandeur Marleen van der Most Jeroen Koomen Lucien van Keulen Annemieke Dinkla Xander Luinenburg Marieke Escher Pieter Jacobs Ingrid Keur Guy C.M. Grinwis Erik Weerts Els M. Broens Richard Anthony Miranda Kamst-van Agterveld Karin Rebel Erik Huisman Marloes Heijne Ad Koets Mycobacterium bovis infected domestic cats in an officially bovine tuberculosis free country resulting in human infection One Health Feline tuberculosis Mycobacterium bovis Zoonosis Human transmission Officially bTB free (OTF) country The Netherlands |
| title | Mycobacterium bovis infected domestic cats in an officially bovine tuberculosis free country resulting in human infection |
| title_full | Mycobacterium bovis infected domestic cats in an officially bovine tuberculosis free country resulting in human infection |
| title_fullStr | Mycobacterium bovis infected domestic cats in an officially bovine tuberculosis free country resulting in human infection |
| title_full_unstemmed | Mycobacterium bovis infected domestic cats in an officially bovine tuberculosis free country resulting in human infection |
| title_short | Mycobacterium bovis infected domestic cats in an officially bovine tuberculosis free country resulting in human infection |
| title_sort | mycobacterium bovis infected domestic cats in an officially bovine tuberculosis free country resulting in human infection |
| topic | Feline tuberculosis Mycobacterium bovis Zoonosis Human transmission Officially bTB free (OTF) country The Netherlands |
| url | http://www.sciencedirect.com/science/article/pii/S2352771425000849 |
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