The role of neutrophils in vasculitis associated with antineutrophil cytoplasmic antibodies
Vasculitis associated with antineutrophil cytoplasmic antibodies (AAV) is a potentially dangerous autoimmune disease characterized by necrotizing inflammation of small blood vessels. In the pathogenesis of AAV, both innate and adaptive immunity are closely linked to neutrophil function. The study of...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
IMA-PRESS LLC
2024-12-01
|
| Series: | Современная ревматология |
| Subjects: | |
| Online Access: | https://mrj.ima-press.net/mrj/article/view/1672 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849744294074646528 |
|---|---|
| author | E. N. Vorkel T. M. Reshetnyak A. M. Lila |
| author_facet | E. N. Vorkel T. M. Reshetnyak A. M. Lila |
| author_sort | E. N. Vorkel |
| collection | DOAJ |
| description | Vasculitis associated with antineutrophil cytoplasmic antibodies (AAV) is a potentially dangerous autoimmune disease characterized by necrotizing inflammation of small blood vessels. In the pathogenesis of AAV, both innate and adaptive immunity are closely linked to neutrophil function. The study of the pathogenetic mechanisms of neutrophil activation in AAV may serve as a prerequisite for the development of more accurate and modern methods of laboratory diagnostics as well as new treatment approaches targeting neutrophils. The review presents an analysis of studies addressing the issue of neutrophil activation in AAV. |
| format | Article |
| id | doaj-art-baa6a50a6ecf40ff86624b967206441b |
| institution | DOAJ |
| issn | 1996-7012 2310-158X |
| language | Russian |
| publishDate | 2024-12-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj-art-baa6a50a6ecf40ff86624b967206441b2025-08-20T03:20:58ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2024-12-01186909710.14412/1996-7012-2024-6-90-972743The role of neutrophils in vasculitis associated with antineutrophil cytoplasmic antibodiesE. N. Vorkel0T. M. Reshetnyak1A. M. Lila2V.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of Rheumatology; Department of Rheumatology Russian Medical Academy of Continuing Professional Education, Ministry of Health of RussiaV.A. Nasonova Research Institute of Rheumatology; Department of Rheumatology Russian Medical Academy of Continuing Professional Education, Ministry of Health of RussiaVasculitis associated with antineutrophil cytoplasmic antibodies (AAV) is a potentially dangerous autoimmune disease characterized by necrotizing inflammation of small blood vessels. In the pathogenesis of AAV, both innate and adaptive immunity are closely linked to neutrophil function. The study of the pathogenetic mechanisms of neutrophil activation in AAV may serve as a prerequisite for the development of more accurate and modern methods of laboratory diagnostics as well as new treatment approaches targeting neutrophils. The review presents an analysis of studies addressing the issue of neutrophil activation in AAV.https://mrj.ima-press.net/mrj/article/view/1672vasculitis associated with antineutrophil cytoplasmic antibodiesneutrophilsnetosisneutrophil extracellular traps |
| spellingShingle | E. N. Vorkel T. M. Reshetnyak A. M. Lila The role of neutrophils in vasculitis associated with antineutrophil cytoplasmic antibodies Современная ревматология vasculitis associated with antineutrophil cytoplasmic antibodies neutrophils netosis neutrophil extracellular traps |
| title | The role of neutrophils in vasculitis associated with antineutrophil cytoplasmic antibodies |
| title_full | The role of neutrophils in vasculitis associated with antineutrophil cytoplasmic antibodies |
| title_fullStr | The role of neutrophils in vasculitis associated with antineutrophil cytoplasmic antibodies |
| title_full_unstemmed | The role of neutrophils in vasculitis associated with antineutrophil cytoplasmic antibodies |
| title_short | The role of neutrophils in vasculitis associated with antineutrophil cytoplasmic antibodies |
| title_sort | role of neutrophils in vasculitis associated with antineutrophil cytoplasmic antibodies |
| topic | vasculitis associated with antineutrophil cytoplasmic antibodies neutrophils netosis neutrophil extracellular traps |
| url | https://mrj.ima-press.net/mrj/article/view/1672 |
| work_keys_str_mv | AT envorkel theroleofneutrophilsinvasculitisassociatedwithantineutrophilcytoplasmicantibodies AT tmreshetnyak theroleofneutrophilsinvasculitisassociatedwithantineutrophilcytoplasmicantibodies AT amlila theroleofneutrophilsinvasculitisassociatedwithantineutrophilcytoplasmicantibodies AT envorkel roleofneutrophilsinvasculitisassociatedwithantineutrophilcytoplasmicantibodies AT tmreshetnyak roleofneutrophilsinvasculitisassociatedwithantineutrophilcytoplasmicantibodies AT amlila roleofneutrophilsinvasculitisassociatedwithantineutrophilcytoplasmicantibodies |