Shifts in growth strategies reflect tradeoffs in cellular economics
Abstract The growth rate‐dependent regulation of cell size, ribosomal content, and metabolic efficiency follows a common pattern in unicellular organisms: with increasing growth rates, cell size and ribosomal content increase and a shift to energetically inefficient metabolism takes place. The latte...
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| Format: | Article |
| Language: | English |
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Springer Nature
2009-11-01
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| Series: | Molecular Systems Biology |
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| Online Access: | https://doi.org/10.1038/msb.2009.82 |
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| author | Douwe Molenaar Rogier van Berlo Dick de Ridder Bas Teusink |
| author_facet | Douwe Molenaar Rogier van Berlo Dick de Ridder Bas Teusink |
| author_sort | Douwe Molenaar |
| collection | DOAJ |
| description | Abstract The growth rate‐dependent regulation of cell size, ribosomal content, and metabolic efficiency follows a common pattern in unicellular organisms: with increasing growth rates, cell size and ribosomal content increase and a shift to energetically inefficient metabolism takes place. The latter two phenomena are also observed in fast growing tumour cells and cell lines. These patterns suggest a fundamental principle of design. In biology such designs can often be understood as the result of the optimization of fitness. Here we show that in basic models of self‐replicating systems these patterns are the consequence of maximizing the growth rate. Whereas most models of cellular growth consider a part of physiology, for instance only metabolism, the approach presented here integrates several subsystems to a complete self‐replicating system. Such models can yield fundamentally different optimal strategies. In particular, it is shown how the shift in metabolic efficiency originates from a tradeoff between investments in enzyme synthesis and metabolic yields for alternative catabolic pathways. The models elucidate how the optimization of growth by natural selection shapes growth strategies. |
| format | Article |
| id | doaj-art-baa1a5504fa54e42b114ea4c034f1f6c |
| institution | Kabale University |
| issn | 1744-4292 |
| language | English |
| publishDate | 2009-11-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | Molecular Systems Biology |
| spelling | doaj-art-baa1a5504fa54e42b114ea4c034f1f6c2025-08-24T11:59:33ZengSpringer NatureMolecular Systems Biology1744-42922009-11-015111010.1038/msb.2009.82Shifts in growth strategies reflect tradeoffs in cellular economicsDouwe Molenaar0Rogier van Berlo1Dick de Ridder2Bas Teusink3Centre for Integrative Bioinformatics (IBIVU), Vrije Universiteit AmsterdamInformation and Communication Theory Group, Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of TechnologyInformation and Communication Theory Group, Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of TechnologyCentre for Integrative Bioinformatics (IBIVU), Vrije Universiteit AmsterdamAbstract The growth rate‐dependent regulation of cell size, ribosomal content, and metabolic efficiency follows a common pattern in unicellular organisms: with increasing growth rates, cell size and ribosomal content increase and a shift to energetically inefficient metabolism takes place. The latter two phenomena are also observed in fast growing tumour cells and cell lines. These patterns suggest a fundamental principle of design. In biology such designs can often be understood as the result of the optimization of fitness. Here we show that in basic models of self‐replicating systems these patterns are the consequence of maximizing the growth rate. Whereas most models of cellular growth consider a part of physiology, for instance only metabolism, the approach presented here integrates several subsystems to a complete self‐replicating system. Such models can yield fundamentally different optimal strategies. In particular, it is shown how the shift in metabolic efficiency originates from a tradeoff between investments in enzyme synthesis and metabolic yields for alternative catabolic pathways. The models elucidate how the optimization of growth by natural selection shapes growth strategies.https://doi.org/10.1038/msb.2009.82growthmetabolic efficiencyoverflow metabolismribosome contentWarburg effect |
| spellingShingle | Douwe Molenaar Rogier van Berlo Dick de Ridder Bas Teusink Shifts in growth strategies reflect tradeoffs in cellular economics Molecular Systems Biology growth metabolic efficiency overflow metabolism ribosome content Warburg effect |
| title | Shifts in growth strategies reflect tradeoffs in cellular economics |
| title_full | Shifts in growth strategies reflect tradeoffs in cellular economics |
| title_fullStr | Shifts in growth strategies reflect tradeoffs in cellular economics |
| title_full_unstemmed | Shifts in growth strategies reflect tradeoffs in cellular economics |
| title_short | Shifts in growth strategies reflect tradeoffs in cellular economics |
| title_sort | shifts in growth strategies reflect tradeoffs in cellular economics |
| topic | growth metabolic efficiency overflow metabolism ribosome content Warburg effect |
| url | https://doi.org/10.1038/msb.2009.82 |
| work_keys_str_mv | AT douwemolenaar shiftsingrowthstrategiesreflecttradeoffsincellulareconomics AT rogiervanberlo shiftsingrowthstrategiesreflecttradeoffsincellulareconomics AT dickderidder shiftsingrowthstrategiesreflecttradeoffsincellulareconomics AT basteusink shiftsingrowthstrategiesreflecttradeoffsincellulareconomics |