Sanqi oral solution alleviates podocyte apoptosis in experimental membranous nephropathy by mediating EMT through the ERK/CK2-α/β-catenin pathway

Sanqi oral solution alleviates podocyte apoptosis in experimental membranous nephropathy by mediating EMT through the ERK/CK2-α/β-catenin pathway

IntroductionSanqi oral solution (SQ) is a Chinese medicine that has been used well to treat idiopathic membranous nephropathy (IMN). It has been demonstrated to mitigate IMN proteinuria by inhibiting podocyte apoptosis. however, the precise mechanism has not been fully elucidated.MethodsA passive He...

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Main Authors: Xiaowan Wang, Juanjuan Wang, Bidan Zheng, Ruimin Tian, Lihua Huang, Wei Mao, Yi Feng, Bo Liu, Peng Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
passive heymann nephropathy
sanqi oral solution
apoptosis
epithelialmesenchymal transition
the ERK/CK2-α/β-catenin pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1503961/full
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