Higher Clinical Frailty Scale is Associated with Higher Visit-to-Visit Glycated Hemoglobin (HbA1c) Variability in Patients with Type 2 Diabetes Mellitus: A Propensity Score-Matched Study
Yuping Zhang, Sha Gang, Wen Yu Department of General Practice, Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Yuping Zhang, Department of General Practice, Beijing Tongren Hospital, Capital Medical University, No. 8 Chongwenmennei Road, Dongc...
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Dove Medical Press
2025-05-01
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| author | Zhang Y Gang S Yu W |
| author_facet | Zhang Y Gang S Yu W |
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| description | Yuping Zhang, Sha Gang, Wen Yu Department of General Practice, Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Yuping Zhang, Department of General Practice, Beijing Tongren Hospital, Capital Medical University, No. 8 Chongwenmennei Road, Dongcheng District, Beijing, People’s Republic of China, 100730, Tel +8615810171490, Email 15810171490@139.comObjective: Patients with type 2 diabetes mellitus (T2DM) have high risk of frailty. The clinical frailty scale (CFS) has been used to evaluate clinical frailty. To evaluate the association between CFS and visit-to-visit glycated hemoglobin (HbA1C) variability in T2DM patients.Methods: Patients who were hospitalized with T2DM and received at least three HbA1C tests after discharging from endocrinology department and general practice department during 12-month follow-up were retrospectively enrolled. The patients were divided into the low-HbA1C variability group and the high-HbA1C variability group according to the results of the HbA1C variability score (HVS). The baseline clinical information, including CFS during hospitalization, was collected and compared between the two groups. We performed a propensity score match (PSM) to eliminate the influences of other confounding factors.Results: A total of 370 patients were included in this study. Most baseline demographic, clinical parameters and metabolic parameters were comparable between the two groups except age, baseline HbA1C, albumin, and comorbidities including hypertension and dyslipidemia between the two groups before PSM. All of the relative parameters were comparable after a 1:1 PSM. Uni-variable and multi-variable logistic analysis revealed that higher CFS was associated with higher HbA1C variability and receiver operating characteristic curve showed that CFS had good predictive value in HVS.Conclusion: Higher CFS was associated with higher visit-to-visit HbA1C variability.Keywords: clinical frailty scale, HbA1C variability score, type 2 diabetes mellitus, propensity score match |
| format | Article |
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| institution | Kabale University |
| issn | 1178-1998 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj-art-ba9b112f490a4a63864555edf3c7fc9b2025-08-20T03:32:33ZengDove Medical PressClinical Interventions in Aging1178-19982025-05-01Volume 20Issue 1751762103408Higher Clinical Frailty Scale is Associated with Higher Visit-to-Visit Glycated Hemoglobin (HbA1c) Variability in Patients with Type 2 Diabetes Mellitus: A Propensity Score-Matched StudyZhang Y0Gang SYu WEndocrinologyYuping Zhang, Sha Gang, Wen Yu Department of General Practice, Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Yuping Zhang, Department of General Practice, Beijing Tongren Hospital, Capital Medical University, No. 8 Chongwenmennei Road, Dongcheng District, Beijing, People’s Republic of China, 100730, Tel +8615810171490, Email 15810171490@139.comObjective: Patients with type 2 diabetes mellitus (T2DM) have high risk of frailty. The clinical frailty scale (CFS) has been used to evaluate clinical frailty. To evaluate the association between CFS and visit-to-visit glycated hemoglobin (HbA1C) variability in T2DM patients.Methods: Patients who were hospitalized with T2DM and received at least three HbA1C tests after discharging from endocrinology department and general practice department during 12-month follow-up were retrospectively enrolled. The patients were divided into the low-HbA1C variability group and the high-HbA1C variability group according to the results of the HbA1C variability score (HVS). The baseline clinical information, including CFS during hospitalization, was collected and compared between the two groups. We performed a propensity score match (PSM) to eliminate the influences of other confounding factors.Results: A total of 370 patients were included in this study. Most baseline demographic, clinical parameters and metabolic parameters were comparable between the two groups except age, baseline HbA1C, albumin, and comorbidities including hypertension and dyslipidemia between the two groups before PSM. All of the relative parameters were comparable after a 1:1 PSM. Uni-variable and multi-variable logistic analysis revealed that higher CFS was associated with higher HbA1C variability and receiver operating characteristic curve showed that CFS had good predictive value in HVS.Conclusion: Higher CFS was associated with higher visit-to-visit HbA1C variability.Keywords: clinical frailty scale, HbA1C variability score, type 2 diabetes mellitus, propensity score matchhttps://www.dovepress.com/higher-clinical-frailty-scale-is-associated-with-higher-visit-to-visit-peer-reviewed-fulltext-article-CIAclinical frailty scaleHbA1C variability scoretype 2 diabetes mellituspropensity score match. |
| spellingShingle | Zhang Y Gang S Yu W Higher Clinical Frailty Scale is Associated with Higher Visit-to-Visit Glycated Hemoglobin (HbA1c) Variability in Patients with Type 2 Diabetes Mellitus: A Propensity Score-Matched Study Clinical Interventions in Aging clinical frailty scale HbA1C variability score type 2 diabetes mellitus propensity score match. |
| title | Higher Clinical Frailty Scale is Associated with Higher Visit-to-Visit Glycated Hemoglobin (HbA1c) Variability in Patients with Type 2 Diabetes Mellitus: A Propensity Score-Matched Study |
| title_full | Higher Clinical Frailty Scale is Associated with Higher Visit-to-Visit Glycated Hemoglobin (HbA1c) Variability in Patients with Type 2 Diabetes Mellitus: A Propensity Score-Matched Study |
| title_fullStr | Higher Clinical Frailty Scale is Associated with Higher Visit-to-Visit Glycated Hemoglobin (HbA1c) Variability in Patients with Type 2 Diabetes Mellitus: A Propensity Score-Matched Study |
| title_full_unstemmed | Higher Clinical Frailty Scale is Associated with Higher Visit-to-Visit Glycated Hemoglobin (HbA1c) Variability in Patients with Type 2 Diabetes Mellitus: A Propensity Score-Matched Study |
| title_short | Higher Clinical Frailty Scale is Associated with Higher Visit-to-Visit Glycated Hemoglobin (HbA1c) Variability in Patients with Type 2 Diabetes Mellitus: A Propensity Score-Matched Study |
| title_sort | higher clinical frailty scale is associated with higher visit to visit glycated hemoglobin hba1c variability in patients with type 2 diabetes mellitus a propensity score matched study |
| topic | clinical frailty scale HbA1C variability score type 2 diabetes mellitus propensity score match. |
| url | https://www.dovepress.com/higher-clinical-frailty-scale-is-associated-with-higher-visit-to-visit-peer-reviewed-fulltext-article-CIA |
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