Scutellaria baicalensis Georgi in metabolic-associated fatty liver disease treatment: research progress
Metabolic associated fatty liver disease (MAFLD), previously known as nonalcoholic fatty liver disease (NAFLD), is a common liver condition marked by excessive fat accumulation exceeding 5% in the liver without significant alcohol consumption. It is closely linked to metabolic disorders such as obes...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1565461/full |
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| author | Liping Chen Enhe Liu Xi Zhao Xiao Liu Qin Dong Yinpei Lou Guoying Huang Ling Li Yuxin He |
| author_facet | Liping Chen Enhe Liu Xi Zhao Xiao Liu Qin Dong Yinpei Lou Guoying Huang Ling Li Yuxin He |
| author_sort | Liping Chen |
| collection | DOAJ |
| description | Metabolic associated fatty liver disease (MAFLD), previously known as nonalcoholic fatty liver disease (NAFLD), is a common liver condition marked by excessive fat accumulation exceeding 5% in the liver without significant alcohol consumption. It is closely linked to metabolic disorders such as obesity, type 2 diabetes, and dyslipidemia, with a rising global prevalence projected to escalate from 25% to 56% over the next decade. The pathogenesis of MAFLD is multifaceted, involving insulin resistance, inflammation, and oxidative stress, with progressive symptoms that can lead to severe liver conditions including non-alcoholic steatohepatitis (NASH). Current treatment options are limited, as established medications show variable efficacy and safety. Scutellaria baicalensis Georgi (S. baicalensis) a traditional Chinese herb rich in flavonoids, has garnered attention for its potential therapeutic effects on MAFLD. Its pharmacological activities, including anti-inflammatory, antioxidant, and lipid-regulating properties, position S. baicalensis as a promising candidate for MAFLD management. This article reviews the latest research progress of S. baicalensis in the treatment of MAFLD, explores its mechanism of action, pharmacokinetics, and the development of related products, aiming to clarify the pathogenesis of MAFLD and promote the development of new treatment and prevention strategies based on traditional Chinese medicine. |
| format | Article |
| id | doaj-art-ba96dd7f1dfe436d82fd791fc1b8d4bb |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pharmacology |
| spelling | doaj-art-ba96dd7f1dfe436d82fd791fc1b8d4bb2025-08-20T02:32:07ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-06-011610.3389/fphar.2025.15654611565461Scutellaria baicalensis Georgi in metabolic-associated fatty liver disease treatment: research progressLiping Chen0Enhe Liu1Xi Zhao2Xiao Liu3Qin Dong4Yinpei Lou5Guoying Huang6Ling Li7Yuxin He8School of Comprehensive Health Management, Xihua University, Chengdu, ChinaSchool of Food and Bioengineering, Xihua University, Chengdu, ChinaSchool of Food and Bioengineering, Xihua University, Chengdu, ChinaSchool of Food and Bioengineering, Xihua University, Chengdu, ChinaSchool of Food and Bioengineering, Xihua University, Chengdu, ChinaSchool of Comprehensive Health Management, Xihua University, Chengdu, ChinaSchool of Pharmaceutical and Environmental Engineering, Sichuan Vocational College of Chemical Technology, Luzhou, ChinaSchool of Food and Bioengineering, Xihua University, Chengdu, ChinaSchool of Food and Bioengineering, Xihua University, Chengdu, ChinaMetabolic associated fatty liver disease (MAFLD), previously known as nonalcoholic fatty liver disease (NAFLD), is a common liver condition marked by excessive fat accumulation exceeding 5% in the liver without significant alcohol consumption. It is closely linked to metabolic disorders such as obesity, type 2 diabetes, and dyslipidemia, with a rising global prevalence projected to escalate from 25% to 56% over the next decade. The pathogenesis of MAFLD is multifaceted, involving insulin resistance, inflammation, and oxidative stress, with progressive symptoms that can lead to severe liver conditions including non-alcoholic steatohepatitis (NASH). Current treatment options are limited, as established medications show variable efficacy and safety. Scutellaria baicalensis Georgi (S. baicalensis) a traditional Chinese herb rich in flavonoids, has garnered attention for its potential therapeutic effects on MAFLD. Its pharmacological activities, including anti-inflammatory, antioxidant, and lipid-regulating properties, position S. baicalensis as a promising candidate for MAFLD management. This article reviews the latest research progress of S. baicalensis in the treatment of MAFLD, explores its mechanism of action, pharmacokinetics, and the development of related products, aiming to clarify the pathogenesis of MAFLD and promote the development of new treatment and prevention strategies based on traditional Chinese medicine.https://www.frontiersin.org/articles/10.3389/fphar.2025.1565461/fullmetabolic associated fatty liver diseaseScutellaria baicalensis Georgipharmacological activitiespharmacokineticsproduction development |
| spellingShingle | Liping Chen Enhe Liu Xi Zhao Xiao Liu Qin Dong Yinpei Lou Guoying Huang Ling Li Yuxin He Scutellaria baicalensis Georgi in metabolic-associated fatty liver disease treatment: research progress Frontiers in Pharmacology metabolic associated fatty liver disease Scutellaria baicalensis Georgi pharmacological activities pharmacokinetics production development |
| title | Scutellaria baicalensis Georgi in metabolic-associated fatty liver disease treatment: research progress |
| title_full | Scutellaria baicalensis Georgi in metabolic-associated fatty liver disease treatment: research progress |
| title_fullStr | Scutellaria baicalensis Georgi in metabolic-associated fatty liver disease treatment: research progress |
| title_full_unstemmed | Scutellaria baicalensis Georgi in metabolic-associated fatty liver disease treatment: research progress |
| title_short | Scutellaria baicalensis Georgi in metabolic-associated fatty liver disease treatment: research progress |
| title_sort | scutellaria baicalensis georgi in metabolic associated fatty liver disease treatment research progress |
| topic | metabolic associated fatty liver disease Scutellaria baicalensis Georgi pharmacological activities pharmacokinetics production development |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1565461/full |
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