Neutropenia in rheumatoid arthritis and large granular lymphocyte leucosis
Objective. Pts with chronic clonal proliferation of large granular lymphocytes (LGL leukemia) often have neutropenia, splenomegaly, and rheumatoid arthritis (RA), thereby resembling the manifestations observed in pts with Felty’s syndrome. The present study sought to indicate that pts with these dis...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
IMA PRESS LLC
2003-02-01
|
| Series: | Научно-практическая ревматология |
| Subjects: | |
| Online Access: | https://rsp.mediar-press.net/rsp/article/view/1044 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849688939074420736 |
|---|---|
| author | V A Doronin E A Nikitin J. V. Sidorova A. V. Pivnik |
| author_facet | V A Doronin E A Nikitin J. V. Sidorova A. V. Pivnik |
| author_sort | V A Doronin |
| collection | DOAJ |
| description | Objective. Pts with chronic clonal proliferation of large granular lymphocytes (LGL leukemia) often have neutropenia, splenomegaly, and rheumatoid arthritis (RA), thereby resembling the manifestations observed in pts with Felty’s syndrome. The present study sought to indicate that pts with these disorders represent two distinct subsets. We compare clinical, hematological, immunophenotiping and immunogenetic features in Felty’s syndrome pts with and without the LGL leukemia. Material and methods 10 pts with T-LGL leukemia were studied. Surface phenotype was estimated using monoclonal antibodies CD8-PE and CD3-FITC/CD16-PE (two-color) (Caltag, USA) by the flow cytometric analysis (Partec, Daco). Analysis of TCR gene rearrangement was performed by using PCR-LIS SSCP (low ionic strength single strand conformational polymorphism). Comparison with Felty s syndrome and RA pts based on the review of literature. Results. LGL leukemia is a distinct clinicopathologic entity often associated with RA. LGL leukemia pts with RA showed the same immunogenetis associations seen in RA/Felty’s syndrome, while LGL leukemia pts without arthritis did not. Conclusion. Hematologic, immunophenotyping and molecular genetic analysis are very important and highly representative tools in differential diagnosis of neutropenia in RA, and propose that Felty’s syndrome and LGL leukemia represent different variants of broader syndrome comprising RA, neutropenia, LGL expansions, and splenomegaly. |
| format | Article |
| id | doaj-art-ba96bd327c014af8bef570c2abee03b1 |
| institution | DOAJ |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2003-02-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-ba96bd327c014af8bef570c2abee03b12025-08-20T03:21:47ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922003-02-01411151810.14412/1995-4484-2003-1126984Neutropenia in rheumatoid arthritis and large granular lymphocyte leucosisV A DoroninE A NikitinJ. V. SidorovaA. V. PivnikObjective. Pts with chronic clonal proliferation of large granular lymphocytes (LGL leukemia) often have neutropenia, splenomegaly, and rheumatoid arthritis (RA), thereby resembling the manifestations observed in pts with Felty’s syndrome. The present study sought to indicate that pts with these disorders represent two distinct subsets. We compare clinical, hematological, immunophenotiping and immunogenetic features in Felty’s syndrome pts with and without the LGL leukemia. Material and methods 10 pts with T-LGL leukemia were studied. Surface phenotype was estimated using monoclonal antibodies CD8-PE and CD3-FITC/CD16-PE (two-color) (Caltag, USA) by the flow cytometric analysis (Partec, Daco). Analysis of TCR gene rearrangement was performed by using PCR-LIS SSCP (low ionic strength single strand conformational polymorphism). Comparison with Felty s syndrome and RA pts based on the review of literature. Results. LGL leukemia is a distinct clinicopathologic entity often associated with RA. LGL leukemia pts with RA showed the same immunogenetis associations seen in RA/Felty’s syndrome, while LGL leukemia pts without arthritis did not. Conclusion. Hematologic, immunophenotyping and molecular genetic analysis are very important and highly representative tools in differential diagnosis of neutropenia in RA, and propose that Felty’s syndrome and LGL leukemia represent different variants of broader syndrome comprising RA, neutropenia, LGL expansions, and splenomegaly.https://rsp.mediar-press.net/rsp/article/view/1044large granular lymphocytes leukemiarheumatoid arthritisfelty's syndrome |
| spellingShingle | V A Doronin E A Nikitin J. V. Sidorova A. V. Pivnik Neutropenia in rheumatoid arthritis and large granular lymphocyte leucosis Научно-практическая ревматология large granular lymphocytes leukemia rheumatoid arthritis felty's syndrome |
| title | Neutropenia in rheumatoid arthritis and large granular lymphocyte leucosis |
| title_full | Neutropenia in rheumatoid arthritis and large granular lymphocyte leucosis |
| title_fullStr | Neutropenia in rheumatoid arthritis and large granular lymphocyte leucosis |
| title_full_unstemmed | Neutropenia in rheumatoid arthritis and large granular lymphocyte leucosis |
| title_short | Neutropenia in rheumatoid arthritis and large granular lymphocyte leucosis |
| title_sort | neutropenia in rheumatoid arthritis and large granular lymphocyte leucosis |
| topic | large granular lymphocytes leukemia rheumatoid arthritis felty's syndrome |
| url | https://rsp.mediar-press.net/rsp/article/view/1044 |
| work_keys_str_mv | AT vadoronin neutropeniainrheumatoidarthritisandlargegranularlymphocyteleucosis AT eanikitin neutropeniainrheumatoidarthritisandlargegranularlymphocyteleucosis AT jvsidorova neutropeniainrheumatoidarthritisandlargegranularlymphocyteleucosis AT avpivnik neutropeniainrheumatoidarthritisandlargegranularlymphocyteleucosis |