Assisted reproductive technology and association with childhood cancer subtypes
Abstract Objectives To investigate the association between assisted reproductive technology (ART) use and childhood cancer subtype. Study Design We deployed a cross‐sectional survey of 1701 parents of children with cancer about their ART use, demographics, and gestational and perinatal factors. Mult...
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| Format: | Article |
| Language: | English |
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Wiley
2023-02-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.5114 |
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| author | Natalie B. Gulrajani Samuel Montes Daniel McGough Courtney E. Wimberly Ameera Khattab Eleanor C. Semmes Lisa Towry Jennifer L. Cohen Jillian H. Hurst Daniel Landi Sherika N. Hill Kyle M. Walsh |
| author_facet | Natalie B. Gulrajani Samuel Montes Daniel McGough Courtney E. Wimberly Ameera Khattab Eleanor C. Semmes Lisa Towry Jennifer L. Cohen Jillian H. Hurst Daniel Landi Sherika N. Hill Kyle M. Walsh |
| author_sort | Natalie B. Gulrajani |
| collection | DOAJ |
| description | Abstract Objectives To investigate the association between assisted reproductive technology (ART) use and childhood cancer subtype. Study Design We deployed a cross‐sectional survey of 1701 parents of children with cancer about their ART use, demographics, and gestational and perinatal factors. Multivariable logistic regression modeled the association between ART use, birthweight and multiple gestation status with childhood cancer, by subtype. Results ART use was highest among children with osteosarcoma relative to children with other cancer types, and this association was statistically significant in multivariable models (OR = 4.4; 95% CI = 1.7–11.3; p = 0.0020). ART use was also elevated among children with hepatoblastoma, but this relationship appeared to be due to the strong associations between ART use and lower birthweight in our sample. No specific ART modality appeared to drive these associations. In univariate models, multiple gestation was associated with a 2.7‐fold increased odds of hepatoblastoma (OR = 2.71; 95% CI = 1.14–6.42; p = 0.02) and a 1.6‐fold increased odds of neuroblastoma (OR = 1.62; 95% CI = 1.03–2.54; p = 0.03), but these associations were not retained in multivariable models. Conclusions Associations between ART use and hepatoblastoma risk may be attributable to birthweight, a known hepatoblastoma risk factor. ART use may also be associated with osteosarcoma, independent of birthweight, an association not previously observed in studies limited to cancers diagnosed before adolescence. Evaluating long‐term health outcomes in children conceived by ART, throughout adolescence and potentially into adulthood, appears warranted. |
| format | Article |
| id | doaj-art-ba922fa4b95b4b92a59ff2606f8deb5d |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-ba922fa4b95b4b92a59ff2606f8deb5d2024-11-25T07:56:32ZengWileyCancer Medicine2045-76342023-02-011233410341810.1002/cam4.5114Assisted reproductive technology and association with childhood cancer subtypesNatalie B. Gulrajani0Samuel Montes1Daniel McGough2Courtney E. Wimberly3Ameera Khattab4Eleanor C. Semmes5Lisa Towry6Jennifer L. Cohen7Jillian H. Hurst8Daniel Landi9Sherika N. Hill10Kyle M. Walsh11Children's Health and Discovery Institute, Department of Pediatrics Duke University School of Medicine Durham North Carolina USAMaster of Biomedical Sciences Program Duke University School of Medicine Durham North Carolina USAMaster of Biomedical Sciences Program Duke University School of Medicine Durham North Carolina USADepartment of Neurosurgery and Preston Robert Tisch Brain Tumor Center Duke University School of Medicine Durham North Carolina USAMaster of Biomedical Sciences Program Duke University School of Medicine Durham North Carolina USAChildren's Health and Discovery Institute, Department of Pediatrics Duke University School of Medicine Durham North Carolina USAMy Childhood Cancer Program Alex's Lemonade Stand Foundation Bala Cynwyd Pennsylvania USADivision of Medical Genetics, Department of Pediatrics Duke University School of Medicine Durham North Carolina USAChildren's Health and Discovery Institute, Department of Pediatrics Duke University School of Medicine Durham North Carolina USADepartment of Neurosurgery and Preston Robert Tisch Brain Tumor Center Duke University School of Medicine Durham North Carolina USAChildren's Health and Discovery Institute, Department of Pediatrics Duke University School of Medicine Durham North Carolina USAChildren's Health and Discovery Institute, Department of Pediatrics Duke University School of Medicine Durham North Carolina USAAbstract Objectives To investigate the association between assisted reproductive technology (ART) use and childhood cancer subtype. Study Design We deployed a cross‐sectional survey of 1701 parents of children with cancer about their ART use, demographics, and gestational and perinatal factors. Multivariable logistic regression modeled the association between ART use, birthweight and multiple gestation status with childhood cancer, by subtype. Results ART use was highest among children with osteosarcoma relative to children with other cancer types, and this association was statistically significant in multivariable models (OR = 4.4; 95% CI = 1.7–11.3; p = 0.0020). ART use was also elevated among children with hepatoblastoma, but this relationship appeared to be due to the strong associations between ART use and lower birthweight in our sample. No specific ART modality appeared to drive these associations. In univariate models, multiple gestation was associated with a 2.7‐fold increased odds of hepatoblastoma (OR = 2.71; 95% CI = 1.14–6.42; p = 0.02) and a 1.6‐fold increased odds of neuroblastoma (OR = 1.62; 95% CI = 1.03–2.54; p = 0.03), but these associations were not retained in multivariable models. Conclusions Associations between ART use and hepatoblastoma risk may be attributable to birthweight, a known hepatoblastoma risk factor. ART use may also be associated with osteosarcoma, independent of birthweight, an association not previously observed in studies limited to cancers diagnosed before adolescence. Evaluating long‐term health outcomes in children conceived by ART, throughout adolescence and potentially into adulthood, appears warranted.https://doi.org/10.1002/cam4.5114assisted reproductive technologycancer risk factorsepidemiologyin vitro fertilizationliver cancerosteosarcoma |
| spellingShingle | Natalie B. Gulrajani Samuel Montes Daniel McGough Courtney E. Wimberly Ameera Khattab Eleanor C. Semmes Lisa Towry Jennifer L. Cohen Jillian H. Hurst Daniel Landi Sherika N. Hill Kyle M. Walsh Assisted reproductive technology and association with childhood cancer subtypes Cancer Medicine assisted reproductive technology cancer risk factors epidemiology in vitro fertilization liver cancer osteosarcoma |
| title | Assisted reproductive technology and association with childhood cancer subtypes |
| title_full | Assisted reproductive technology and association with childhood cancer subtypes |
| title_fullStr | Assisted reproductive technology and association with childhood cancer subtypes |
| title_full_unstemmed | Assisted reproductive technology and association with childhood cancer subtypes |
| title_short | Assisted reproductive technology and association with childhood cancer subtypes |
| title_sort | assisted reproductive technology and association with childhood cancer subtypes |
| topic | assisted reproductive technology cancer risk factors epidemiology in vitro fertilization liver cancer osteosarcoma |
| url | https://doi.org/10.1002/cam4.5114 |
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