Chitosan oligosaccharide attenuates acute kidney injury and renal interstitial fibrosis induced by ischemia-reperfusion
Acute kidney injury (AKI) and renal interstitial fibrosis are global clinical syndromes associated with high morbidity and mortality. Renal ischemia-reperfusion (I/R) injury, which commonly occurs during surgery, is one of the major causes of AKI. Nevertheless, an efficient therapeutic approach for...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2238831 |
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| author | Shulan Yin Jiane Liu Xiangzhong Zhao Hanyu Dong Yanjing Cao Sudan Zhang Xiaolei Dong Guangmin Zhang Shengxi Jin Weiping Shi Fenggang Xiang Jizheng Gong Ziyi Wang Baoqin Han Na Zhang Xiaohua Tan Zheng Wang |
| author_facet | Shulan Yin Jiane Liu Xiangzhong Zhao Hanyu Dong Yanjing Cao Sudan Zhang Xiaolei Dong Guangmin Zhang Shengxi Jin Weiping Shi Fenggang Xiang Jizheng Gong Ziyi Wang Baoqin Han Na Zhang Xiaohua Tan Zheng Wang |
| author_sort | Shulan Yin |
| collection | DOAJ |
| description | Acute kidney injury (AKI) and renal interstitial fibrosis are global clinical syndromes associated with high morbidity and mortality. Renal ischemia-reperfusion (I/R) injury, which commonly occurs during surgery, is one of the major causes of AKI. Nevertheless, an efficient therapeutic approach for AKI and the development of renal interstitial fibrosis is still lacking due to its elusive pathogenetic mechanism. Here, we showed that chitosan oligosaccharide (COS), a natural oligomer polysaccharide degraded from chitosan, significantly attenuates I/R-induced AKI and maintains glomerular filtration function by inhibiting oxidative stress, mitochondrial damage, and excessive endoplasmic reticulum stress both in vitro and in vivo. In addition, long-term administration of COS can also attenuate the proliferation of myofibroblasts, mitigate extra cellular matrix deposition, and thus inhibit the transition of AKI to chronic kidney disease through participating in metabolic and redox biological processes. Our findings provide novel insights into the protective role of COS against acute kidney injury. |
| format | Article |
| id | doaj-art-ba90f7d4bfa645e3816b56e8badf721e |
| institution | DOAJ |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-ba90f7d4bfa645e3816b56e8badf721e2025-08-20T02:56:11ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492023-12-0145110.1080/0886022X.2023.2238831Chitosan oligosaccharide attenuates acute kidney injury and renal interstitial fibrosis induced by ischemia-reperfusionShulan Yin0Jiane Liu1Xiangzhong Zhao2Hanyu Dong3Yanjing Cao4Sudan Zhang5Xiaolei Dong6Guangmin Zhang7Shengxi Jin8Weiping Shi9Fenggang Xiang10Jizheng Gong11Ziyi Wang12Baoqin Han13Na Zhang14Xiaohua Tan15Zheng Wang16Department of Reproductive Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Reproductive Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaMedical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Endocrinology, Zibo Maternal and Child Health Care Hospital, Zibo, Shandong, ChinaDepartment of Pathology, School of Basic Medicine, Qingdao University, Qingdao, Shandong, ChinaDepartment of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao, Shandong, ChinaDepartment of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao, Shandong, ChinaDepartment of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao, Shandong, ChinaDepartment of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao, Shandong, ChinaDepartment of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Pathology, School of Basic Medicine, Qingdao University, Qingdao, Shandong, ChinaDepartment of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao, Shandong, ChinaDepartment of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao, Shandong, ChinaLaboratory for Marine Drugs and Bioproducts of Pilot National Laboratory for Marine Science and Technology, Ocean University of China, Qingdao, ChinaYantai Zhifu Baoshang Hemodialysis Center, Yantai, Shandong, ChinaDepartment of Pathology, School of Basic Medicine, Qingdao University, Qingdao, Shandong, ChinaDepartment of Reproductive Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaAcute kidney injury (AKI) and renal interstitial fibrosis are global clinical syndromes associated with high morbidity and mortality. Renal ischemia-reperfusion (I/R) injury, which commonly occurs during surgery, is one of the major causes of AKI. Nevertheless, an efficient therapeutic approach for AKI and the development of renal interstitial fibrosis is still lacking due to its elusive pathogenetic mechanism. Here, we showed that chitosan oligosaccharide (COS), a natural oligomer polysaccharide degraded from chitosan, significantly attenuates I/R-induced AKI and maintains glomerular filtration function by inhibiting oxidative stress, mitochondrial damage, and excessive endoplasmic reticulum stress both in vitro and in vivo. In addition, long-term administration of COS can also attenuate the proliferation of myofibroblasts, mitigate extra cellular matrix deposition, and thus inhibit the transition of AKI to chronic kidney disease through participating in metabolic and redox biological processes. Our findings provide novel insights into the protective role of COS against acute kidney injury.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2238831AKICOSrenal interstitial fibrosisI/R injury |
| spellingShingle | Shulan Yin Jiane Liu Xiangzhong Zhao Hanyu Dong Yanjing Cao Sudan Zhang Xiaolei Dong Guangmin Zhang Shengxi Jin Weiping Shi Fenggang Xiang Jizheng Gong Ziyi Wang Baoqin Han Na Zhang Xiaohua Tan Zheng Wang Chitosan oligosaccharide attenuates acute kidney injury and renal interstitial fibrosis induced by ischemia-reperfusion Renal Failure AKI COS renal interstitial fibrosis I/R injury |
| title | Chitosan oligosaccharide attenuates acute kidney injury and renal interstitial fibrosis induced by ischemia-reperfusion |
| title_full | Chitosan oligosaccharide attenuates acute kidney injury and renal interstitial fibrosis induced by ischemia-reperfusion |
| title_fullStr | Chitosan oligosaccharide attenuates acute kidney injury and renal interstitial fibrosis induced by ischemia-reperfusion |
| title_full_unstemmed | Chitosan oligosaccharide attenuates acute kidney injury and renal interstitial fibrosis induced by ischemia-reperfusion |
| title_short | Chitosan oligosaccharide attenuates acute kidney injury and renal interstitial fibrosis induced by ischemia-reperfusion |
| title_sort | chitosan oligosaccharide attenuates acute kidney injury and renal interstitial fibrosis induced by ischemia reperfusion |
| topic | AKI COS renal interstitial fibrosis I/R injury |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2238831 |
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