A human B‐cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers

A human B‐cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers

Abstract Assembly of a transcriptional and post‐translational molecular interaction network in B cells, the human B‐cell interactome (HBCI), reveals a hierarchical, transcriptional control module, where MYB and FOXM1 act as synergistic master regulators of proliferation in the germinal center (GC)....

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Bibliographic Details
Main Authors: Celine Lefebvre, Presha Rajbhandari, Mariano J Alvarez, Pradeep Bandaru, Wei Keat Lim, Mai Sato, Kai Wang, Pavel Sumazin, Manjunath Kustagi, Brygida C Bisikirska, Katia Basso, Pedro Beltrao, Nevan Krogan, Jean Gautier, Riccardo Dalla‐Favera, Andrea Califano
Format: Article
Language:English
Published: Springer Nature 2010-06-01
Series:Molecular Systems Biology
Subjects:
B cell
germinal centers
interactome
master regulator
Online Access:https://doi.org/10.1038/msb.2010.31
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