Excessive expression of progranulin leads to neurotoxicity rather than neuroprotection

Excessive expression of progranulin leads to neurotoxicity rather than neuroprotection

Frontotemporal dementia (FTD) is an early onset form of dementia characterized by frontotemporal lobar atrophy accompanied by behavioral, personality, language, and motor deficits. Heterozygous mutations in GRN gene encoding progranulin (PGRN) are the genetic causes of FTD. Since PGRN is a neurotrop...

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Bibliographic Details
Main Authors: Shinya Kusakari, Hiroaki Suzuki, Mikiro Nawa, Katsuko Sudo, Rio Yamazaki, Tamami Miyagi, Tomoko Ohara, Masaaki Matsuoka, Kohsuke Kanekura
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Neurobiology of Disease
Subjects:
Progranulin (PGRN)
Frontotemporal dementia
Neurodegeneration
Neuronal death
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125001111
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