Diagnostic accuracy of the parameters from ganglion cell complex map, evaluated with SD-OCT in primary open-angle glaucoma
Purpose: To evaluate the sensitivity and specificity of ganglion cell complex (GCC) parameters, obtained with optical coherence tomography (OCT) and to determine their accuracy and ability to differentiate healthy from primary open-angle glaucoma patients. Patients and methods. 84 eyes of primary op...
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Ophthalmology Publishing Group
2014-10-01
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| Series: | Oftalʹmologiâ |
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| Online Access: | https://www.ophthalmojournal.com/opht/article/view/185 |
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| author | B. Anguelov K. Petrova |
| author_facet | B. Anguelov K. Petrova |
| author_sort | B. Anguelov |
| collection | DOAJ |
| description | Purpose: To evaluate the sensitivity and specificity of ganglion cell complex (GCC) parameters, obtained with optical coherence tomography (OCT) and to determine their accuracy and ability to differentiate healthy from primary open-angle glaucoma patients. Patients and methods. 84 eyes of primary open-angle glaucoma patients and 40 eyes of healthy individuals were enrolled in the study. All of them underwent complete eye examination, including standard automated perimetry (HFA II) and OCT (RTVue-100). Avg. GCC (average GCC), Sup. GCC (superior GCC), Inf. GCC (inferior GCC), GLV (globаl loss volume), FLV (focal loss volume) and RNFL (retinal nerve fiber layer — ONH map) were measured. ROC curveswere created and sensitivity and specificity were calculated for each of these parameters.Results.The highest sensitivity and specificity was found for GLV and the lowest for Sup. GCC. Area under the ROC curves (AUC) for GLV was found to be the largest and the smallest for Sup. GCC.Conclusion. Parameters from GCC map have high sensitivity and specificity. Their diagnostic capability is similar, even slightly better than the one of RNFL. GLV has the highest diagnostic accuracy for primary open-angle glaucoma detection in this study. |
| format | Article |
| id | doaj-art-ba88041f4e514efe8ac0c02f79bceb8e |
| institution | DOAJ |
| issn | 1816-5095 2500-0845 |
| language | Russian |
| publishDate | 2014-10-01 |
| publisher | Ophthalmology Publishing Group |
| record_format | Article |
| series | Oftalʹmologiâ |
| spelling | doaj-art-ba88041f4e514efe8ac0c02f79bceb8e2025-08-20T02:56:16ZrusOphthalmology Publishing GroupOftalʹmologiâ1816-50952500-08452014-10-01113283210.18008/1816-5095-2014-3-28-32185Diagnostic accuracy of the parameters from ganglion cell complex map, evaluated with SD-OCT in primary open-angle glaucomaB. Anguelov0K. Petrova1Department of Ophthalmology, Medical University «Alexandrovska» HospitalDepartment of Ophthalmology, Medical University «Alexandrovska» HospitalPurpose: To evaluate the sensitivity and specificity of ganglion cell complex (GCC) parameters, obtained with optical coherence tomography (OCT) and to determine their accuracy and ability to differentiate healthy from primary open-angle glaucoma patients. Patients and methods. 84 eyes of primary open-angle glaucoma patients and 40 eyes of healthy individuals were enrolled in the study. All of them underwent complete eye examination, including standard automated perimetry (HFA II) and OCT (RTVue-100). Avg. GCC (average GCC), Sup. GCC (superior GCC), Inf. GCC (inferior GCC), GLV (globаl loss volume), FLV (focal loss volume) and RNFL (retinal nerve fiber layer — ONH map) were measured. ROC curveswere created and sensitivity and specificity were calculated for each of these parameters.Results.The highest sensitivity and specificity was found for GLV and the lowest for Sup. GCC. Area under the ROC curves (AUC) for GLV was found to be the largest and the smallest for Sup. GCC.Conclusion. Parameters from GCC map have high sensitivity and specificity. Their diagnostic capability is similar, even slightly better than the one of RNFL. GLV has the highest diagnostic accuracy for primary open-angle glaucoma detection in this study.https://www.ophthalmojournal.com/opht/article/view/185ganglion cell complexoptical coherence tomographyprimary open-angle glaucoma |
| spellingShingle | B. Anguelov K. Petrova Diagnostic accuracy of the parameters from ganglion cell complex map, evaluated with SD-OCT in primary open-angle glaucoma Oftalʹmologiâ ganglion cell complex optical coherence tomography primary open-angle glaucoma |
| title | Diagnostic accuracy of the parameters from ganglion cell complex map, evaluated with SD-OCT in primary open-angle glaucoma |
| title_full | Diagnostic accuracy of the parameters from ganglion cell complex map, evaluated with SD-OCT in primary open-angle glaucoma |
| title_fullStr | Diagnostic accuracy of the parameters from ganglion cell complex map, evaluated with SD-OCT in primary open-angle glaucoma |
| title_full_unstemmed | Diagnostic accuracy of the parameters from ganglion cell complex map, evaluated with SD-OCT in primary open-angle glaucoma |
| title_short | Diagnostic accuracy of the parameters from ganglion cell complex map, evaluated with SD-OCT in primary open-angle glaucoma |
| title_sort | diagnostic accuracy of the parameters from ganglion cell complex map evaluated with sd oct in primary open angle glaucoma |
| topic | ganglion cell complex optical coherence tomography primary open-angle glaucoma |
| url | https://www.ophthalmojournal.com/opht/article/view/185 |
| work_keys_str_mv | AT banguelov diagnosticaccuracyoftheparametersfromganglioncellcomplexmapevaluatedwithsdoctinprimaryopenangleglaucoma AT kpetrova diagnosticaccuracyoftheparametersfromganglioncellcomplexmapevaluatedwithsdoctinprimaryopenangleglaucoma |