Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China
The large scale genome wide association studies (GWAS) have identified approximately 80 single nucleotide polymorphisms (SNPs) conferring susceptibility to type 2 diabetes (T2D). However, most of these loci have not been replicated in diverse populations and much genetic heterogeneity has been obser...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/613236 |
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| author | Haihua Bai Haiping Liu Suyalatu Suyalatu Xiaosen Guo Shandan Chu Ying Chen Tianming Lan Burenbatu Borjigin Yuriy L. Orlov Olga L. Posukh Xiuqin Yang Guilan Guilan Ludmila P. Osipova Qizhu Wu Narisu Narisu |
| author_facet | Haihua Bai Haiping Liu Suyalatu Suyalatu Xiaosen Guo Shandan Chu Ying Chen Tianming Lan Burenbatu Borjigin Yuriy L. Orlov Olga L. Posukh Xiuqin Yang Guilan Guilan Ludmila P. Osipova Qizhu Wu Narisu Narisu |
| author_sort | Haihua Bai |
| collection | DOAJ |
| description | The large scale genome wide association studies (GWAS) have identified approximately 80 single nucleotide polymorphisms (SNPs) conferring susceptibility to type 2 diabetes (T2D). However, most of these loci have not been replicated in diverse populations and much genetic heterogeneity has been observed across ethnic groups. We tested 28 SNPs previously found to be associated with T2D by GWAS in a Mongolian sample of Northern China (497 diagnosed with T2D and 469 controls) for association with T2D and diabetes related quantitative traits. We replicated T2D association of 11 SNPs, namely, rs7578326 (IRS1), rs1531343 (HMGA2), rs8042680 (PRC1), rs7578597 (THADA), rs1333051 (CDKN2), rs6723108 (TMEM163), rs163182 and rs2237897 (KCNQ1), rs1387153 (MTNR1B), rs243021 (BCL11A), and rs10229583 (PAX4) in our sample. Further, we showed that risk allele of the strongest T2D associated SNP in our sample, rs757832 (IRS1), is associated with increased level of TG. We observed substantial difference of T2D risk allele frequency between the Mongolian sample and the 1000G Caucasian sample for a few SNPs, including rs6723108 (TMEM163) whose risk allele reaches near fixation in the Mongolian sample. Further study of genetic architecture of these variants in susceptibility of T2D is needed to understand the role of these variants in heterogeneous populations. |
| format | Article |
| id | doaj-art-ba85a9d251ec4b2b84a4367b9ceef987 |
| institution | DOAJ |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-ba85a9d251ec4b2b84a4367b9ceef9872025-08-20T03:22:52ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/613236613236Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in ChinaHaihua Bai0Haiping Liu1Suyalatu Suyalatu2Xiaosen Guo3Shandan Chu4Ying Chen5Tianming Lan6Burenbatu Borjigin7Yuriy L. Orlov8Olga L. Posukh9Xiuqin Yang10Guilan Guilan11Ludmila P. Osipova12Qizhu Wu13Narisu Narisu14Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia 028000, ChinaInner Mongolia University for the Nationalities, Tongliao, Inner Mongolia 028000, ChinaInner Mongolia University for the Nationalities, Tongliao, Inner Mongolia 028000, ChinaBGI-Shenzhen, Shenzhen 518083, ChinaInner Mongolia University for the Nationalities, Tongliao, Inner Mongolia 028000, ChinaBGI-Shenzhen, Shenzhen 518083, ChinaBGI-Shenzhen, Shenzhen 518083, ChinaInner Mongolia University for the Nationalities, Tongliao, Inner Mongolia 028000, ChinaThe Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences (SB RAS), Novosibirsk 630090, RussiaThe Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences (SB RAS), Novosibirsk 630090, RussiaCollege of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, ChinaInner Mongolia University for the Nationalities, Tongliao, Inner Mongolia 028000, ChinaThe Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences (SB RAS), Novosibirsk 630090, RussiaInner Mongolia University for the Nationalities, Tongliao, Inner Mongolia 028000, ChinaMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USAThe large scale genome wide association studies (GWAS) have identified approximately 80 single nucleotide polymorphisms (SNPs) conferring susceptibility to type 2 diabetes (T2D). However, most of these loci have not been replicated in diverse populations and much genetic heterogeneity has been observed across ethnic groups. We tested 28 SNPs previously found to be associated with T2D by GWAS in a Mongolian sample of Northern China (497 diagnosed with T2D and 469 controls) for association with T2D and diabetes related quantitative traits. We replicated T2D association of 11 SNPs, namely, rs7578326 (IRS1), rs1531343 (HMGA2), rs8042680 (PRC1), rs7578597 (THADA), rs1333051 (CDKN2), rs6723108 (TMEM163), rs163182 and rs2237897 (KCNQ1), rs1387153 (MTNR1B), rs243021 (BCL11A), and rs10229583 (PAX4) in our sample. Further, we showed that risk allele of the strongest T2D associated SNP in our sample, rs757832 (IRS1), is associated with increased level of TG. We observed substantial difference of T2D risk allele frequency between the Mongolian sample and the 1000G Caucasian sample for a few SNPs, including rs6723108 (TMEM163) whose risk allele reaches near fixation in the Mongolian sample. Further study of genetic architecture of these variants in susceptibility of T2D is needed to understand the role of these variants in heterogeneous populations.http://dx.doi.org/10.1155/2015/613236 |
| spellingShingle | Haihua Bai Haiping Liu Suyalatu Suyalatu Xiaosen Guo Shandan Chu Ying Chen Tianming Lan Burenbatu Borjigin Yuriy L. Orlov Olga L. Posukh Xiuqin Yang Guilan Guilan Ludmila P. Osipova Qizhu Wu Narisu Narisu Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China Journal of Diabetes Research |
| title | Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China |
| title_full | Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China |
| title_fullStr | Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China |
| title_full_unstemmed | Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China |
| title_short | Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China |
| title_sort | association analysis of genetic variants with type 2 diabetes in a mongolian population in china |
| url | http://dx.doi.org/10.1155/2015/613236 |
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