Synthesis of novel trans-2,3-dihydrofuran-pyrazole conjugates through molecular hybridization: molecular docking insights and evaluation of anti-inflammatory and anti-malarial activities

Synthesis of novel trans-2,3-dihydrofuran-pyrazole conjugates through molecular hybridization: molecular docking insights and evaluation of anti-inflammatory and anti-malarial activities

Abstract A series of some new trans 2,3-dihydrofuran-linked pyrazole hybrids were synthesized from a convenient one-pot methodology. This procedure employs a sequential one-pot, two-step tandem reaction starting from pyridine, formylpyrazole, dimedone, and phenacyl bromide, with triethylamine servin...

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Bibliographic Details
Main Authors:	Ginna Kumari, Priyanka Rani, Sudeep Dhillon, Mamta Chahal, Binesh Kumar, Jai Devi, Deepak Kumar Aneja, Mayank Kinger
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Series:	BMC Chemistry
Subjects:	Pyrazole Dihydrofuran Molecular docking Inflammation Anti-malarial activity
Online Access:	https://doi.org/10.1186/s13065-025-01438-w
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