Emodin protects against severe acute pancreatitis-associated acute lung injury by activating Nrf2/HO-1/GPX4 signal and inhibiting ferroptosis in vivo and in vitro

Emodin protects against severe acute pancreatitis-associated acute lung injury by activating Nrf2/HO-1/GPX4 signal and inhibiting ferroptosis in vivo and in vitro

Abstract Background Severe acute pancreatitis (SAP) has high morbidity, a complicated and dangerous course, and many complications, including severe pulmonary complications. SAP-associated acute lung injury (SAP-ALI) is still a significant challenge for surgeons because of its high mortality. Theref...

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Bibliographic Details
Main Authors: Gang Shen, Haiyun Wen, Huijuan Li, Xuetao Zhang, Bowen Lan, Xuanchi Dong, Peng Ge, Yalan Luo, Hailong Chen
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Gastroenterology
Subjects:
Ferroptosis
SAP-ALI
Emodin
Nrf2
GPX4
HO-1
Online Access:https://doi.org/10.1186/s12876-025-03660-1
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