Tristetraprolin mediates anti-inflammatory effect of carbon monoxide against DSS-induced colitis.
Endogenous carbon monoxide (CO) exerts anti-inflammatory effects. Tristetraprolin (TTP) is known to destabilize pro-inflammatory transcripts. Here we found that exogenous CO enhanced the decay of TNF-α mRNA and suppressed TNF-α expression in LPS-activated macrophages from wild-type (WT) mice. Howeve...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0088776&type=printable |
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| author | Yeonsoo Joe Md Jamal Uddin Min Zheng Hyo Jeong Kim Yingqing Chen Nal Ae Yoon Gyeong Jae Cho Jeong Woo Park Hun Taeg Chung |
| author_facet | Yeonsoo Joe Md Jamal Uddin Min Zheng Hyo Jeong Kim Yingqing Chen Nal Ae Yoon Gyeong Jae Cho Jeong Woo Park Hun Taeg Chung |
| author_sort | Yeonsoo Joe |
| collection | DOAJ |
| description | Endogenous carbon monoxide (CO) exerts anti-inflammatory effects. Tristetraprolin (TTP) is known to destabilize pro-inflammatory transcripts. Here we found that exogenous CO enhanced the decay of TNF-α mRNA and suppressed TNF-α expression in LPS-activated macrophages from wild-type (WT) mice. However, TTP deficiency abrogated the effects of exogenous CO. While CO treatment prior to DSS administration in WT mice significantly reduced inflammatory cytokine levels and colitis, it failed to reduce the pro-inflammatory cytokine levels and colitis in TTP knockout (KO) mice. Our results demonstrate that TTP is a key factor mediating the anti-inflammatory action of CO in DSS-induced colitis. |
| format | Article |
| id | doaj-art-ba806f1d752c49b3b63cf4cddee7b365 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-ba806f1d752c49b3b63cf4cddee7b3652025-08-20T03:11:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0192e8877610.1371/journal.pone.0088776Tristetraprolin mediates anti-inflammatory effect of carbon monoxide against DSS-induced colitis.Yeonsoo JoeMd Jamal UddinMin ZhengHyo Jeong KimYingqing ChenNal Ae YoonGyeong Jae ChoJeong Woo ParkHun Taeg ChungEndogenous carbon monoxide (CO) exerts anti-inflammatory effects. Tristetraprolin (TTP) is known to destabilize pro-inflammatory transcripts. Here we found that exogenous CO enhanced the decay of TNF-α mRNA and suppressed TNF-α expression in LPS-activated macrophages from wild-type (WT) mice. However, TTP deficiency abrogated the effects of exogenous CO. While CO treatment prior to DSS administration in WT mice significantly reduced inflammatory cytokine levels and colitis, it failed to reduce the pro-inflammatory cytokine levels and colitis in TTP knockout (KO) mice. Our results demonstrate that TTP is a key factor mediating the anti-inflammatory action of CO in DSS-induced colitis.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0088776&type=printable |
| spellingShingle | Yeonsoo Joe Md Jamal Uddin Min Zheng Hyo Jeong Kim Yingqing Chen Nal Ae Yoon Gyeong Jae Cho Jeong Woo Park Hun Taeg Chung Tristetraprolin mediates anti-inflammatory effect of carbon monoxide against DSS-induced colitis. PLoS ONE |
| title | Tristetraprolin mediates anti-inflammatory effect of carbon monoxide against DSS-induced colitis. |
| title_full | Tristetraprolin mediates anti-inflammatory effect of carbon monoxide against DSS-induced colitis. |
| title_fullStr | Tristetraprolin mediates anti-inflammatory effect of carbon monoxide against DSS-induced colitis. |
| title_full_unstemmed | Tristetraprolin mediates anti-inflammatory effect of carbon monoxide against DSS-induced colitis. |
| title_short | Tristetraprolin mediates anti-inflammatory effect of carbon monoxide against DSS-induced colitis. |
| title_sort | tristetraprolin mediates anti inflammatory effect of carbon monoxide against dss induced colitis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0088776&type=printable |
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