Calreticulin Mutated Essential Thrombocythemia Presenting as Acute Coronary Syndrome
Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by a clonal expansion of megakaryocytes. ET can result in both arterial and venous thrombosis. Involvement of the coronary arteries has been reported. Patients who harbor a CALR mutation are half as likely to suffer a thro...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2015/161764 |
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| _version_ | 1850175960819695616 |
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| author | Bassel Nazha Gwenalyn Garcia Ruben Kandov Marcel Odaimi |
| author_facet | Bassel Nazha Gwenalyn Garcia Ruben Kandov Marcel Odaimi |
| author_sort | Bassel Nazha |
| collection | DOAJ |
| description | Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by a clonal expansion of megakaryocytes. ET can result in both arterial and venous thrombosis. Involvement of the coronary arteries has been reported. Patients who harbor a CALR mutation are half as likely to suffer a thrombotic event as compared to patients with a JAK2 mutation. We report a case of CALR-mutated ET whose initial disease manifestation was a non-ST segment elevation myocardial infarction. |
| format | Article |
| id | doaj-art-ba7fe5d6c61d4c078af424763b31fd4c |
| institution | OA Journals |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-ba7fe5d6c61d4c078af424763b31fd4c2025-08-20T02:19:21ZengWileyCase Reports in Hematology2090-65602090-65792015-01-01201510.1155/2015/161764161764Calreticulin Mutated Essential Thrombocythemia Presenting as Acute Coronary SyndromeBassel Nazha0Gwenalyn Garcia1Ruben Kandov2Marcel Odaimi3Department of Medicine, Staten Island University Hospital, Staten Island, NY 10305, USADepartment of Hematology/Oncology, Staten Island University Hospital, Staten Island, NY 10305, USADepartment of Cardiology, Staten Island University Hospital, Staten Island, NY 10305, USADepartment of Hematology/Oncology, Staten Island University Hospital, Staten Island, NY 10305, USAEssential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by a clonal expansion of megakaryocytes. ET can result in both arterial and venous thrombosis. Involvement of the coronary arteries has been reported. Patients who harbor a CALR mutation are half as likely to suffer a thrombotic event as compared to patients with a JAK2 mutation. We report a case of CALR-mutated ET whose initial disease manifestation was a non-ST segment elevation myocardial infarction.http://dx.doi.org/10.1155/2015/161764 |
| spellingShingle | Bassel Nazha Gwenalyn Garcia Ruben Kandov Marcel Odaimi Calreticulin Mutated Essential Thrombocythemia Presenting as Acute Coronary Syndrome Case Reports in Hematology |
| title | Calreticulin Mutated Essential Thrombocythemia Presenting as Acute Coronary Syndrome |
| title_full | Calreticulin Mutated Essential Thrombocythemia Presenting as Acute Coronary Syndrome |
| title_fullStr | Calreticulin Mutated Essential Thrombocythemia Presenting as Acute Coronary Syndrome |
| title_full_unstemmed | Calreticulin Mutated Essential Thrombocythemia Presenting as Acute Coronary Syndrome |
| title_short | Calreticulin Mutated Essential Thrombocythemia Presenting as Acute Coronary Syndrome |
| title_sort | calreticulin mutated essential thrombocythemia presenting as acute coronary syndrome |
| url | http://dx.doi.org/10.1155/2015/161764 |
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