Elevation of soluble interleukin-2 receptor levels in nasal allergy
To investigate soluble IL-2 receptor (sIL-2R) levels in nasal allergy, the sera and nasal secretions from patients with nasal allergy and from healthy subjects were subjected to a double-epitope enzyme-linked immunosorbent assay. Significant elevation of sIL-2R concentrations in the sera and nasal s...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1995-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S096293519500007X |
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| author | K. Hisamatsu T. Ganbo T. Nakazawa S. Horiguchi S. Shimomura Y. Murakami |
| author_facet | K. Hisamatsu T. Ganbo T. Nakazawa S. Horiguchi S. Shimomura Y. Murakami |
| author_sort | K. Hisamatsu |
| collection | DOAJ |
| description | To investigate soluble IL-2 receptor (sIL-2R) levels in nasal allergy, the sera and nasal secretions from patients with nasal allergy and from healthy subjects were subjected to a double-epitope enzyme-linked immunosorbent assay. Significant elevation of sIL-2R concentrations in the sera and nasal secretions was observed in the allergy patients (n = 26) compared with those of healthy subjects (n = 9). IL-2R-positive (CD25+) cells were observed in the crust formed in an allergic nasal mucosa. The concentration of sIL-2R in the sera correlated neither with the eosinophil count of the peripheral blood count nor with clinical severity. The concentration of sIL-2R in the nasal secretions was significantly higher compared with that in the sera from allergic patients (p < 0.01), whereas no significant difference was observed between sIL-2R levels in the sera and nasal sections from normal subjects. These findings indicate that sIL-2R plays an essential role in allergic processes by regulating IL-2R-positive cells recruited into the nasal mucosa. |
| format | Article |
| id | doaj-art-ba7e4fca6af8424b815bdc96bcfab687 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1995-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-ba7e4fca6af8424b815bdc96bcfab6872025-08-20T02:19:21ZengWileyMediators of Inflammation0962-93511466-18611995-01-0141394210.1155/S096293519500007XElevation of soluble interleukin-2 receptor levels in nasal allergyK. Hisamatsu0T. Ganbo1T. Nakazawa2S. Horiguchi3S. Shimomura4Y. Murakami5Department of Otorhinolaryngology, Yamanashi Medical University, 1110 Shimokato, Tamaho-cho, Nakakoma-gun, Yamanashi, 409-38, JapanDepartment of Otorhinolaryngology, Yamanashi Medical University, 1110 Shimokato, Tamaho-cho, Nakakoma-gun, Yamanashi, 409-38, JapanDepartment of Otorhinolaryngology, Yamanashi Medical University, 1110 Shimokato, Tamaho-cho, Nakakoma-gun, Yamanashi, 409-38, JapanDepartment of Otorhinolaryngology, Yamanashi Medical University, 1110 Shimokato, Tamaho-cho, Nakakoma-gun, Yamanashi, 409-38, JapanDepartment of Otorhinolaryngology, Yamanashi Medical University, 1110 Shimokato, Tamaho-cho, Nakakoma-gun, Yamanashi, 409-38, JapanDepartment of Otorhinolaryngology, Yamanashi Medical University, 1110 Shimokato, Tamaho-cho, Nakakoma-gun, Yamanashi, 409-38, JapanTo investigate soluble IL-2 receptor (sIL-2R) levels in nasal allergy, the sera and nasal secretions from patients with nasal allergy and from healthy subjects were subjected to a double-epitope enzyme-linked immunosorbent assay. Significant elevation of sIL-2R concentrations in the sera and nasal secretions was observed in the allergy patients (n = 26) compared with those of healthy subjects (n = 9). IL-2R-positive (CD25+) cells were observed in the crust formed in an allergic nasal mucosa. The concentration of sIL-2R in the sera correlated neither with the eosinophil count of the peripheral blood count nor with clinical severity. The concentration of sIL-2R in the nasal secretions was significantly higher compared with that in the sera from allergic patients (p < 0.01), whereas no significant difference was observed between sIL-2R levels in the sera and nasal sections from normal subjects. These findings indicate that sIL-2R plays an essential role in allergic processes by regulating IL-2R-positive cells recruited into the nasal mucosa.http://dx.doi.org/10.1155/S096293519500007X |
| spellingShingle | K. Hisamatsu T. Ganbo T. Nakazawa S. Horiguchi S. Shimomura Y. Murakami Elevation of soluble interleukin-2 receptor levels in nasal allergy Mediators of Inflammation |
| title | Elevation of soluble interleukin-2 receptor levels in nasal allergy |
| title_full | Elevation of soluble interleukin-2 receptor levels in nasal allergy |
| title_fullStr | Elevation of soluble interleukin-2 receptor levels in nasal allergy |
| title_full_unstemmed | Elevation of soluble interleukin-2 receptor levels in nasal allergy |
| title_short | Elevation of soluble interleukin-2 receptor levels in nasal allergy |
| title_sort | elevation of soluble interleukin 2 receptor levels in nasal allergy |
| url | http://dx.doi.org/10.1155/S096293519500007X |
| work_keys_str_mv | AT khisamatsu elevationofsolubleinterleukin2receptorlevelsinnasalallergy AT tganbo elevationofsolubleinterleukin2receptorlevelsinnasalallergy AT tnakazawa elevationofsolubleinterleukin2receptorlevelsinnasalallergy AT shoriguchi elevationofsolubleinterleukin2receptorlevelsinnasalallergy AT sshimomura elevationofsolubleinterleukin2receptorlevelsinnasalallergy AT ymurakami elevationofsolubleinterleukin2receptorlevelsinnasalallergy |