Serum Endothelin-1 and Transforming Growth Factor-β Levels in the Newborns With Respiratory Distress
The purpose of this present study was to evaluate the serum levels of ET-1 and TGF-β in the newborns with respiratory distress. In this study, newborns with respiratory distress hospitalized into the Newborn Intensive Care Unit were included. The highest values of ET-1 and TGF-β were obtained from n...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/85432 |
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| _version_ | 1832562124826607616 |
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| author | Derya Benzer A. Denizmen Aygun Ahmet Godekmerdan A. Nese (Citak) Kurt Saadet Akarsu Erdal Yilmaz |
| author_facet | Derya Benzer A. Denizmen Aygun Ahmet Godekmerdan A. Nese (Citak) Kurt Saadet Akarsu Erdal Yilmaz |
| author_sort | Derya Benzer |
| collection | DOAJ |
| description | The purpose of this present study was to evaluate the serum levels of ET-1 and TGF-β in the newborns with respiratory distress. In this study, newborns with respiratory distress hospitalized into the Newborn Intensive Care Unit were included. The highest values of ET-1 and TGF-β were obtained from newborns with diagnosis as meconium aspiration syndrome (5.70±5.87
pg/mL and 3.75±1.94 pg/mL, resp) in the sample obtained in the first six hours after birth, and these are statistically different from control group (P<.05). Also, same results were obtained for newborns with respiratory distress syndrome (3.37±1.59 pg/mL and 2.05±0.98 pg/mL, resp). After oxygen treatment, ET-1 values obtained in the first six hours of life were decreased regularly in the following days (P<.05). In the differentiating diagnosis of the respiratory distress of newborns, the investigation of ET-1 and TGF-β levels is meaningful. The ET-1 levels investigated in the first six hours is more useful in determining the prognosis, and repeating ET-1 levels in the following days is more meaningful to determine clinical response. |
| format | Article |
| id | doaj-art-ba795b6a7c494d02b71e919eadf80541 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-ba795b6a7c494d02b71e919eadf805412025-02-03T01:23:22ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/8543285432Serum Endothelin-1 and Transforming Growth Factor-β Levels in the Newborns With Respiratory DistressDerya Benzer0A. Denizmen Aygun1Ahmet Godekmerdan2A. Nese (Citak) Kurt3Saadet Akarsu4Erdal Yilmaz5Department of Pediatrics, Firat University Medical Faculty, Elazig 23119, TurkeyDepartment of Pediatrics, Firat University Medical Faculty, Elazig 23119, TurkeyDepartment of Immunology, Firat University Medical Faculty, Elazig 23119, TurkeyDepartment of Pediatrics, Firat University Medical Faculty, Elazig 23119, TurkeyDepartment of Pediatrics, Firat University Medical Faculty, Elazig 23119, TurkeyDepartment of Pediatrics, Firat University Medical Faculty, Elazig 23119, TurkeyThe purpose of this present study was to evaluate the serum levels of ET-1 and TGF-β in the newborns with respiratory distress. In this study, newborns with respiratory distress hospitalized into the Newborn Intensive Care Unit were included. The highest values of ET-1 and TGF-β were obtained from newborns with diagnosis as meconium aspiration syndrome (5.70±5.87 pg/mL and 3.75±1.94 pg/mL, resp) in the sample obtained in the first six hours after birth, and these are statistically different from control group (P<.05). Also, same results were obtained for newborns with respiratory distress syndrome (3.37±1.59 pg/mL and 2.05±0.98 pg/mL, resp). After oxygen treatment, ET-1 values obtained in the first six hours of life were decreased regularly in the following days (P<.05). In the differentiating diagnosis of the respiratory distress of newborns, the investigation of ET-1 and TGF-β levels is meaningful. The ET-1 levels investigated in the first six hours is more useful in determining the prognosis, and repeating ET-1 levels in the following days is more meaningful to determine clinical response.http://dx.doi.org/10.1155/MI/2006/85432 |
| spellingShingle | Derya Benzer A. Denizmen Aygun Ahmet Godekmerdan A. Nese (Citak) Kurt Saadet Akarsu Erdal Yilmaz Serum Endothelin-1 and Transforming Growth Factor-β Levels in the Newborns With Respiratory Distress Mediators of Inflammation |
| title | Serum Endothelin-1 and Transforming Growth Factor-β Levels in the Newborns With Respiratory Distress |
| title_full | Serum Endothelin-1 and Transforming Growth Factor-β Levels in the Newborns With Respiratory Distress |
| title_fullStr | Serum Endothelin-1 and Transforming Growth Factor-β Levels in the Newborns With Respiratory Distress |
| title_full_unstemmed | Serum Endothelin-1 and Transforming Growth Factor-β Levels in the Newborns With Respiratory Distress |
| title_short | Serum Endothelin-1 and Transforming Growth Factor-β Levels in the Newborns With Respiratory Distress |
| title_sort | serum endothelin 1 and transforming growth factor β levels in the newborns with respiratory distress |
| url | http://dx.doi.org/10.1155/MI/2006/85432 |
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