C to U RNA editing of MFN1 is regulated by ADARB1 and associates with favourable prognosis in chronic lymphocytic leukemia

C to U RNA editing of MFN1 is regulated by ADARB1 and associates with favourable prognosis in chronic lymphocytic leukemia

Abstract Cytidine to uridine (C-to-U) as well as adenosine to inosine (A-to-I) RNA editing denotes the posttranscriptional modification of RNA by specialized RNA deaminases. As RNA editing alters the sequence of the RNA, it can affect splicing, stability, miRNA binding and may also lead to recoding...

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Bibliographic Details
Main Authors: Alejandra Gonzalez Martinez, Franz Josef Gassner, Dominik Baumgartner, Philine Hoven, Ekaterina Akimova, Markus Steiner, Stephanie Schlichtner, Stefanie Rauscher, Ferran Nadeu, Elias Campo, Richard Greil, Alexander Egle, Lisa Pleyer, Nadja Zaborsky, Roland Geisberger
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
RNA editing
ADARB1
APOBEC
CLL
Online Access:https://doi.org/10.1038/s41598-025-15666-6
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