The Human Nasal Microbiome: A Perspective Study During the SARS-CoV-2 Pandemic in Malta
The human respiratory tract is colonized by a complex microbial community that helps maintain respiratory health and plays a crucial role in defending the host from infections. Respiratory viruses have been demonstrated to alter microbiota composition, resulting in opportunistic species expansion, a...
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| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/12/12/2570 |
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| author | David Pinzauti Simon De Jaegher Maria D’Aguanno Manuele Biazzo |
| author_facet | David Pinzauti Simon De Jaegher Maria D’Aguanno Manuele Biazzo |
| author_sort | David Pinzauti |
| collection | DOAJ |
| description | The human respiratory tract is colonized by a complex microbial community that helps maintain respiratory health and plays a crucial role in defending the host from infections. Respiratory viruses have been demonstrated to alter microbiota composition, resulting in opportunistic species expansion, and increasing the disease severity and host susceptibility to bacterial co-infections. This study aims to examine the compositional differences in the nasal microbiota between SARS-CoV-2-infected and non-infected patients. We conducted Oxford Nanopore full-length 16S rRNA sequencing on nasal swabs from 94 COVID-19 negative and 85 COVID-19 positive patients collected during the SARS-CoV-2 pandemic in Malta. Our analysis identified significant alpha and beta diversity differences in the nasal microbiota composition among our study groups. We observed a trend toward decreased microbial richness and evenness in the COVID-Positive cohort with and increased abundance of common nasal opportunistic species including <i>Citrobacter koseri</i>, <i>Dolosigranulum pigrum</i>, <i>Haemophilus influenzae</i>, <i>Klebsiella pneumoniae</i>, and <i>Moraxella catarrhalis</i>. The findings from this study are in line with previously published papers identifying key alterations in the nasal microbiota composition associated with SARS-CoV-2 infection. Understanding these microbiome-driven mechanisms could present novel prognostic markers or offer new approaches for disease prevention and treatment. |
| format | Article |
| id | doaj-art-ba71e9759b414acf88d1583114bbddd9 |
| institution | DOAJ |
| issn | 2076-2607 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-ba71e9759b414acf88d1583114bbddd92025-08-20T02:43:53ZengMDPI AGMicroorganisms2076-26072024-12-011212257010.3390/microorganisms12122570The Human Nasal Microbiome: A Perspective Study During the SARS-CoV-2 Pandemic in MaltaDavid Pinzauti0Simon De Jaegher1Maria D’Aguanno2Manuele Biazzo3The BioArte Ltd., Life Science Park, Triq San Giljan, 3000 San Gwann, MaltaThe BioArte Ltd., Life Science Park, Triq San Giljan, 3000 San Gwann, MaltaThe BioArte Ltd., Life Science Park, Triq San Giljan, 3000 San Gwann, MaltaThe BioArte Ltd., Life Science Park, Triq San Giljan, 3000 San Gwann, MaltaThe human respiratory tract is colonized by a complex microbial community that helps maintain respiratory health and plays a crucial role in defending the host from infections. Respiratory viruses have been demonstrated to alter microbiota composition, resulting in opportunistic species expansion, and increasing the disease severity and host susceptibility to bacterial co-infections. This study aims to examine the compositional differences in the nasal microbiota between SARS-CoV-2-infected and non-infected patients. We conducted Oxford Nanopore full-length 16S rRNA sequencing on nasal swabs from 94 COVID-19 negative and 85 COVID-19 positive patients collected during the SARS-CoV-2 pandemic in Malta. Our analysis identified significant alpha and beta diversity differences in the nasal microbiota composition among our study groups. We observed a trend toward decreased microbial richness and evenness in the COVID-Positive cohort with and increased abundance of common nasal opportunistic species including <i>Citrobacter koseri</i>, <i>Dolosigranulum pigrum</i>, <i>Haemophilus influenzae</i>, <i>Klebsiella pneumoniae</i>, and <i>Moraxella catarrhalis</i>. The findings from this study are in line with previously published papers identifying key alterations in the nasal microbiota composition associated with SARS-CoV-2 infection. Understanding these microbiome-driven mechanisms could present novel prognostic markers or offer new approaches for disease prevention and treatment.https://www.mdpi.com/2076-2607/12/12/2570SARS-CoV-2COVID-19full-length 16Shuman nasal microbiome |
| spellingShingle | David Pinzauti Simon De Jaegher Maria D’Aguanno Manuele Biazzo The Human Nasal Microbiome: A Perspective Study During the SARS-CoV-2 Pandemic in Malta Microorganisms SARS-CoV-2 COVID-19 full-length 16S human nasal microbiome |
| title | The Human Nasal Microbiome: A Perspective Study During the SARS-CoV-2 Pandemic in Malta |
| title_full | The Human Nasal Microbiome: A Perspective Study During the SARS-CoV-2 Pandemic in Malta |
| title_fullStr | The Human Nasal Microbiome: A Perspective Study During the SARS-CoV-2 Pandemic in Malta |
| title_full_unstemmed | The Human Nasal Microbiome: A Perspective Study During the SARS-CoV-2 Pandemic in Malta |
| title_short | The Human Nasal Microbiome: A Perspective Study During the SARS-CoV-2 Pandemic in Malta |
| title_sort | human nasal microbiome a perspective study during the sars cov 2 pandemic in malta |
| topic | SARS-CoV-2 COVID-19 full-length 16S human nasal microbiome |
| url | https://www.mdpi.com/2076-2607/12/12/2570 |
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