Engineering hydrophobicity and manufacturability for optimized biparatopic antibody–drug conjugates targeting c-MET

Engineering hydrophobicity and manufacturability for optimized biparatopic antibody–drug conjugates targeting c-MET

Optimal combinations of paratopes assembled into a biparatopic antibody have the capacity to mediate high-grade target cross-linking on cell membranes, leading to degradation of the target, as well as antibody and payload delivery in the case of an antibody-drug conjugate (ADC). In the work presente...

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Bibliographic Details
Main Authors: Andreas Evers, Simon Krah, Deniz Demir, Ramona Gaa, Desislava Elter, Christian Schroeter, Stefan Zielonka, Nicolas Rasche, Julia Dotterweich, Christine Knuehl, Achim Doerner
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
Antibody engineering
Biparatopic ADC
c-MET
hydrophobicity
manufacturability
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2302386
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