PI3K signaling in the locus coeruleus: a new molecular pathway for ADHD research
Abstract Attention‐deficit/hyperactivity disorder (ADHD) is a developmental disorder characterized by hyperactivity, inattention, and impulsive behaviors and has significant societal impact. ADHD is recognized as a heterogeneous disease, and genetic and/or environmental factors underlying pathogenes...
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| Format: | Article |
| Language: | English |
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Springer Nature
2015-04-01
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| Series: | EMBO Molecular Medicine |
| Online Access: | https://doi.org/10.15252/emmm.201505266 |
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| author | Emmanuel Darcq Brigitte L Kieffer |
| author_facet | Emmanuel Darcq Brigitte L Kieffer |
| author_sort | Emmanuel Darcq |
| collection | DOAJ |
| description | Abstract Attention‐deficit/hyperactivity disorder (ADHD) is a developmental disorder characterized by hyperactivity, inattention, and impulsive behaviors and has significant societal impact. ADHD is recognized as a heterogeneous disease, and genetic and/or environmental factors underlying pathogenesis remain largely unknown. There is an obvious need to increase knowledge on molecular signaling and brain pathways underlying disease development, and genetic mouse models are key to this goal. In this issue of EMBO Molecular Medicine, D'Andrea et al (2015) combine state‐of‐the‐art genetic and behavioral approaches in the mouse to demonstrate an essential role for PI3Kγ and cAMP homeostasis in ADHD‐related behaviors, through signaling mechanisms operating at the level of the locus coeruleus, the main source of noradrenaline in the brain. Furthermore, the study posits PI3Kγ knockout mice as a novel tool of high interest for modeling ADHD endophenotypes. |
| format | Article |
| id | doaj-art-ba6bc9a03ff34a70a637e456e9b44c01 |
| institution | DOAJ |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2015-04-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-ba6bc9a03ff34a70a637e456e9b44c012025-08-20T03:05:55ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842015-04-017785986110.15252/emmm.201505266PI3K signaling in the locus coeruleus: a new molecular pathway for ADHD researchEmmanuel Darcq0Brigitte L Kieffer1Department of Psychiatry, Faculty of Medicine, Douglas Hospital Research Center, McGill UniversityDepartment of Psychiatry, Faculty of Medicine, Douglas Hospital Research Center, McGill UniversityAbstract Attention‐deficit/hyperactivity disorder (ADHD) is a developmental disorder characterized by hyperactivity, inattention, and impulsive behaviors and has significant societal impact. ADHD is recognized as a heterogeneous disease, and genetic and/or environmental factors underlying pathogenesis remain largely unknown. There is an obvious need to increase knowledge on molecular signaling and brain pathways underlying disease development, and genetic mouse models are key to this goal. In this issue of EMBO Molecular Medicine, D'Andrea et al (2015) combine state‐of‐the‐art genetic and behavioral approaches in the mouse to demonstrate an essential role for PI3Kγ and cAMP homeostasis in ADHD‐related behaviors, through signaling mechanisms operating at the level of the locus coeruleus, the main source of noradrenaline in the brain. Furthermore, the study posits PI3Kγ knockout mice as a novel tool of high interest for modeling ADHD endophenotypes.https://doi.org/10.15252/emmm.201505266 |
| spellingShingle | Emmanuel Darcq Brigitte L Kieffer PI3K signaling in the locus coeruleus: a new molecular pathway for ADHD research EMBO Molecular Medicine |
| title | PI3K signaling in the locus coeruleus: a new molecular pathway for ADHD research |
| title_full | PI3K signaling in the locus coeruleus: a new molecular pathway for ADHD research |
| title_fullStr | PI3K signaling in the locus coeruleus: a new molecular pathway for ADHD research |
| title_full_unstemmed | PI3K signaling in the locus coeruleus: a new molecular pathway for ADHD research |
| title_short | PI3K signaling in the locus coeruleus: a new molecular pathway for ADHD research |
| title_sort | pi3k signaling in the locus coeruleus a new molecular pathway for adhd research |
| url | https://doi.org/10.15252/emmm.201505266 |
| work_keys_str_mv | AT emmanueldarcq pi3ksignalinginthelocuscoeruleusanewmolecularpathwayforadhdresearch AT brigittelkieffer pi3ksignalinginthelocuscoeruleusanewmolecularpathwayforadhdresearch |