Targeting PGK1 as a Novel strategy to regulate the sensitivity of HER2 positive gastric cancer to lapatinib

Targeting PGK1 as a Novel strategy to regulate the sensitivity of HER2 positive gastric cancer to lapatinib

HER2 is amplified in approximately 20% of gastric cancers, and these patients exhibit a favorable response to trastuzumab treatment. Lapatinib, as a HER2-targeted drug, demonstrates potent inhibitory effects on HER2-addicted N87 gastric cancer cells. However, lapatinib has not shown significant adva...

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Bibliographic Details
Main Authors: Xiaochen Ni, Kaiyuan Zhang, Xueru Huang, Mingsi Zhang, Jianing Guo, Wei Fan, Chuhang Wang, Zhongyan Du, Tao Jiang, Guangji Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
glycolysis
PGK1
lapatinib
HER2 gastric cancer
lactate
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1530492/full
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