Vascular Endothelial Growth Factor Receptor-1 Expression in Breast Cancer and Its Correlation to Vascular Endothelial Growth Factor A
VEGF-A is the most potent angiogenic factor in tumour angiogenesis. Its effects are mediated via two receptors VEGFR-1 and VEGFR-2. Primary aim of our study was to examine the expression of VEGFR-1 in breast cancer and its correlation to VEGF expression, lymph node status, tumour size, histological...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2013/746749 |
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| author | Nahida Srabovic Zlata Mujagic Jasminka Mujanovic-Mustedanagic Adaleta Softic Zdeno Muminovic Adi Rifatbegovic Lejla Begic |
| author_facet | Nahida Srabovic Zlata Mujagic Jasminka Mujanovic-Mustedanagic Adaleta Softic Zdeno Muminovic Adi Rifatbegovic Lejla Begic |
| author_sort | Nahida Srabovic |
| collection | DOAJ |
| description | VEGF-A is the most potent angiogenic factor in tumour angiogenesis. Its effects are mediated via two receptors VEGFR-1 and VEGFR-2. Primary aim of our study was to examine the expression of VEGFR-1 in breast cancer and its correlation to VEGF expression, lymph node status, tumour size, histological grade, and hormone receptor status. To examine the VEGFR-1 and VEGF expressions in tumour and surrounding tissue of 51 breast cancer patients, and in healthy breast tissue of 30 benign breast diseases patients, we used three-step immunohistochemical staining. VEGFR-1 and VEGF expressions were significantly increased in breast cancer tumour in relation to surrounding tissue (P<0.01), and the VEGF expression was significantly increased in lymph node positive breast cancer patients (P<0.01). VEGFR-1 and VEGF expressions were significantly higher in breast cancer tumour compared with healthy breast tissue (P<0.01). Significant correlation between VEGF and VEGFR-1 expressions was found (P<0.05). No significant correlations between VEGF and VEGFR-1 expressions and tumour size, histological grade, and hormone receptor status were found. Increased expression of VEGFR-1 and VEGF in breast cancer tumour and significant correlation between these proteins suggest the possible role of VEGF/VEGFR-1 signalization in breast cancer development, although VEGFR-1 potential prognostic value was not confirmed. |
| format | Article |
| id | doaj-art-ba660fa99a554d508970db75b2de2b70 |
| institution | DOAJ |
| issn | 2090-3170 2090-3189 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-ba660fa99a554d508970db75b2de2b702025-08-20T03:23:12ZengWileyInternational Journal of Breast Cancer2090-31702090-31892013-01-01201310.1155/2013/746749746749Vascular Endothelial Growth Factor Receptor-1 Expression in Breast Cancer and Its Correlation to Vascular Endothelial Growth Factor ANahida Srabovic0Zlata Mujagic1Jasminka Mujanovic-Mustedanagic2Adaleta Softic3Zdeno Muminovic4Adi Rifatbegovic5Lejla Begic6Department of Biochemistry, University of Tuzla, 75 000 Tuzla, Bosnia And HerzegovinaDepartment of Biochemistry, University of Tuzla, 75 000 Tuzla, Bosnia And HerzegovinaPoliclinic of Laboratory Diagnostics, Department of Pathology, University Clinical Centre of Tuzla, 75 000 Tuzla, Bosnia And HerzegovinaDepartment of Biochemistry, University of Tuzla, 75 000 Tuzla, Bosnia And HerzegovinaPoliclinic of Laboratory Diagnostics, Department of Pathology, University Clinical Centre of Tuzla, 75 000 Tuzla, Bosnia And HerzegovinaPoliclinic of Surgery, University Clinical Centre Tuzla, 75 000 Tuzla, Bosnia And HerzegovinaDepartment of Biochemistry, University of Tuzla, 75 000 Tuzla, Bosnia And HerzegovinaVEGF-A is the most potent angiogenic factor in tumour angiogenesis. Its effects are mediated via two receptors VEGFR-1 and VEGFR-2. Primary aim of our study was to examine the expression of VEGFR-1 in breast cancer and its correlation to VEGF expression, lymph node status, tumour size, histological grade, and hormone receptor status. To examine the VEGFR-1 and VEGF expressions in tumour and surrounding tissue of 51 breast cancer patients, and in healthy breast tissue of 30 benign breast diseases patients, we used three-step immunohistochemical staining. VEGFR-1 and VEGF expressions were significantly increased in breast cancer tumour in relation to surrounding tissue (P<0.01), and the VEGF expression was significantly increased in lymph node positive breast cancer patients (P<0.01). VEGFR-1 and VEGF expressions were significantly higher in breast cancer tumour compared with healthy breast tissue (P<0.01). Significant correlation between VEGF and VEGFR-1 expressions was found (P<0.05). No significant correlations between VEGF and VEGFR-1 expressions and tumour size, histological grade, and hormone receptor status were found. Increased expression of VEGFR-1 and VEGF in breast cancer tumour and significant correlation between these proteins suggest the possible role of VEGF/VEGFR-1 signalization in breast cancer development, although VEGFR-1 potential prognostic value was not confirmed.http://dx.doi.org/10.1155/2013/746749 |
| spellingShingle | Nahida Srabovic Zlata Mujagic Jasminka Mujanovic-Mustedanagic Adaleta Softic Zdeno Muminovic Adi Rifatbegovic Lejla Begic Vascular Endothelial Growth Factor Receptor-1 Expression in Breast Cancer and Its Correlation to Vascular Endothelial Growth Factor A International Journal of Breast Cancer |
| title | Vascular Endothelial Growth Factor Receptor-1 Expression in Breast Cancer and Its Correlation to Vascular Endothelial Growth Factor A |
| title_full | Vascular Endothelial Growth Factor Receptor-1 Expression in Breast Cancer and Its Correlation to Vascular Endothelial Growth Factor A |
| title_fullStr | Vascular Endothelial Growth Factor Receptor-1 Expression in Breast Cancer and Its Correlation to Vascular Endothelial Growth Factor A |
| title_full_unstemmed | Vascular Endothelial Growth Factor Receptor-1 Expression in Breast Cancer and Its Correlation to Vascular Endothelial Growth Factor A |
| title_short | Vascular Endothelial Growth Factor Receptor-1 Expression in Breast Cancer and Its Correlation to Vascular Endothelial Growth Factor A |
| title_sort | vascular endothelial growth factor receptor 1 expression in breast cancer and its correlation to vascular endothelial growth factor a |
| url | http://dx.doi.org/10.1155/2013/746749 |
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