Risk factors and drug resistance analysis of fungal infections in maintenance hemodialysis patients
目的探讨维持性血液透析（maintenance hemodialysis,MHD）患者并发真菌感染的菌群分布特点、药敏特点以及发生真菌感染的危险因素,为积极预防,临床合理用药提供依据。方法选取我院肾脏内科2018年1月至2020年3月收治的495例MHD患者为研究对象,根据院内真菌感染的诊断标准,将发生真菌感染的71例患者纳入感染组,将未发生真菌感染的424例患者纳入非感染组。回顾性收集研究对象的临床资料,采用SPSS 26.0软件对我院MHD患者并发真菌感染的菌群分布特点、药敏特点以及危险因素进行统计分析。结果 495例MHD患者中,发生真菌感染者有71例,感染率为14.3%,真菌感染部位以...
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Editorial Department of Journal of Clinical Nephrology
2021-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| author | Chen Qian Zhong Qing Li Man-li Jiang Wei |
| author_facet | Chen Qian Zhong Qing Li Man-li Jiang Wei |
| author_sort | Chen Qian |
| collection | DOAJ |
| description | 目的探讨维持性血液透析（maintenance hemodialysis,MHD）患者并发真菌感染的菌群分布特点、药敏特点以及发生真菌感染的危险因素,为积极预防,临床合理用药提供依据。方法选取我院肾脏内科2018年1月至2020年3月收治的495例MHD患者为研究对象,根据院内真菌感染的诊断标准,将发生真菌感染的71例患者纳入感染组,将未发生真菌感染的424例患者纳入非感染组。回顾性收集研究对象的临床资料,采用SPSS 26.0软件对我院MHD患者并发真菌感染的菌群分布特点、药敏特点以及危险因素进行统计分析。结果 495例MHD患者中,发生真菌感染者有71例,感染率为14.3%,真菌感染部位以肺部最常见,感染主要病原菌为白假丝酵母菌。药敏特点:真菌对两性霉素B、5-氟尿嘧啶、伏立康唑、氟康唑、伊曲康唑、棘白素类药物的耐药率分布为0、1.3%、15.5%、11.2%、14.1%、12.1%;真菌对两性霉素B、5-氟尿嘧啶的耐药率低于伏立康唑、氟康唑、伊曲康唑、棘白素类药物（P<0.05）。多因素Logistic回归分析结果显示糖尿病、白细胞计数<4×10<sup>9</sup>/L、抗生素使用时间≥7 d、使用激素和（或）免疫抑制剂是引起MHD患者发生真菌感染的独立危险因素（P<0.05,OR>1）。结论 MHD患者并发真菌感染部位以肺部最多见,感染菌群以白假丝酵母菌最多见,引起MHD患者真菌感染的危险因素较多,应针对危险因素采取措施积极预防,并根据药敏特点合理使用抗生素。 |
| format | Article |
| id | doaj-art-ba61d20a60c4441fb3ff858a758770f0 |
| institution | OA Journals |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2021-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-ba61d20a60c4441fb3ff858a758770f02025-08-20T02:16:10ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902021-01-0114715257904522Risk factors and drug resistance analysis of fungal infections in maintenance hemodialysis patientsChen QianZhong QingLi Man-liJiang Wei目的探讨维持性血液透析（maintenance hemodialysis,MHD）患者并发真菌感染的菌群分布特点、药敏特点以及发生真菌感染的危险因素,为积极预防,临床合理用药提供依据。方法选取我院肾脏内科2018年1月至2020年3月收治的495例MHD患者为研究对象,根据院内真菌感染的诊断标准,将发生真菌感染的71例患者纳入感染组,将未发生真菌感染的424例患者纳入非感染组。回顾性收集研究对象的临床资料,采用SPSS 26.0软件对我院MHD患者并发真菌感染的菌群分布特点、药敏特点以及危险因素进行统计分析。结果 495例MHD患者中,发生真菌感染者有71例,感染率为14.3%,真菌感染部位以肺部最常见,感染主要病原菌为白假丝酵母菌。药敏特点:真菌对两性霉素B、5-氟尿嘧啶、伏立康唑、氟康唑、伊曲康唑、棘白素类药物的耐药率分布为0、1.3%、15.5%、11.2%、14.1%、12.1%;真菌对两性霉素B、5-氟尿嘧啶的耐药率低于伏立康唑、氟康唑、伊曲康唑、棘白素类药物（P<0.05）。多因素Logistic回归分析结果显示糖尿病、白细胞计数<4×10<sup>9</sup>/L、抗生素使用时间≥7 d、使用激素和（或）免疫抑制剂是引起MHD患者发生真菌感染的独立危险因素（P<0.05,OR>1）。结论 MHD患者并发真菌感染部位以肺部最多见,感染菌群以白假丝酵母菌最多见,引起MHD患者真菌感染的危险因素较多,应针对危险因素采取措施积极预防,并根据药敏特点合理使用抗生素。http://www.lcszb.com/thesisDetails?columnId=57904522&Fpath=home&index=0HemodialysisFungal infectionDrug resistanceDrug susceptibilityRisk factors |
| spellingShingle | Chen Qian Zhong Qing Li Man-li Jiang Wei Risk factors and drug resistance analysis of fungal infections in maintenance hemodialysis patients Linchuang shenzangbing zazhi Hemodialysis Fungal infection Drug resistance Drug susceptibility Risk factors |
| title | Risk factors and drug resistance analysis of fungal infections in maintenance hemodialysis patients |
| title_full | Risk factors and drug resistance analysis of fungal infections in maintenance hemodialysis patients |
| title_fullStr | Risk factors and drug resistance analysis of fungal infections in maintenance hemodialysis patients |
| title_full_unstemmed | Risk factors and drug resistance analysis of fungal infections in maintenance hemodialysis patients |
| title_short | Risk factors and drug resistance analysis of fungal infections in maintenance hemodialysis patients |
| title_sort | risk factors and drug resistance analysis of fungal infections in maintenance hemodialysis patients |
| topic | Hemodialysis Fungal infection Drug resistance Drug susceptibility Risk factors |
| url | http://www.lcszb.com/thesisDetails?columnId=57904522&Fpath=home&index=0 |
| work_keys_str_mv | AT chenqian riskfactorsanddrugresistanceanalysisoffungalinfectionsinmaintenancehemodialysispatients AT zhongqing riskfactorsanddrugresistanceanalysisoffungalinfectionsinmaintenancehemodialysispatients AT limanli riskfactorsanddrugresistanceanalysisoffungalinfectionsinmaintenancehemodialysispatients AT jiangwei riskfactorsanddrugresistanceanalysisoffungalinfectionsinmaintenancehemodialysispatients |