Gaps, challenges and opportunities towards achieving the 95-95-95 targets in Cameroon: A systematic review and meta-analysis protocol.
<h4>Background</h4>Given HIV elimination by 2030, the World Health Organization and the United Nations' Programme on HIV/AIDS (UNAIDS) have set three programmatic goals that all countries should have achieved before 2025; 95% of people living with HIV should know their status (targe...
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Public Library of Science (PLoS)
2025-01-01
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| Online Access: | https://doi.org/10.1371/journal.pone.0317850 |
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| author | Ezechiel Ngoufack Jagni Semengue Alex Durand N K A Pamela Patricia Tueguem Christelle Aude Ka'e Evariste Molimbou Lum Yah Forgwei Naomi-Karell Etame Aurelie Minelle Kengni Ngueko Désiré Takou Aristide Stephane Abah Abah Alice Ketchadji Pamen Bouba David Kob Same Oscar Etogo Basile Keugoung Abdelkader Bacha Phanuel Habimana Martin Samuel Sosso Alexis Ndjolo Carlo-Federico Perno Vittorio Colizzi Rogers Ajeh Anne-Cecile Z-K Bissek Nicaise Ndembi Joseph Fokam |
| author_facet | Ezechiel Ngoufack Jagni Semengue Alex Durand N K A Pamela Patricia Tueguem Christelle Aude Ka'e Evariste Molimbou Lum Yah Forgwei Naomi-Karell Etame Aurelie Minelle Kengni Ngueko Désiré Takou Aristide Stephane Abah Abah Alice Ketchadji Pamen Bouba David Kob Same Oscar Etogo Basile Keugoung Abdelkader Bacha Phanuel Habimana Martin Samuel Sosso Alexis Ndjolo Carlo-Federico Perno Vittorio Colizzi Rogers Ajeh Anne-Cecile Z-K Bissek Nicaise Ndembi Joseph Fokam |
| author_sort | Ezechiel Ngoufack Jagni Semengue |
| collection | DOAJ |
| description | <h4>Background</h4>Given HIV elimination by 2030, the World Health Organization and the United Nations' Programme on HIV/AIDS (UNAIDS) have set three programmatic goals that all countries should have achieved before 2025; 95% of people living with HIV should know their status (target-1); 95% of people who know their status should be linked to treatment (target-2); and 95% of people on treatment should achieve viral load suppression (i.e. VL<1000 copies/ml; target-3). Despite considerable global progress over the past decade, many low-middle-income countries are still below the expected targets. This review protocol aims to provide a standardized document for in-depth analysis of the strengths, weaknesses, opportunities and threats (SWOT) towards achieving these programmatic targets in Cameroon.<h4>Methods</h4>This systematic review will include randomized and non-randomized trials, cohorts, case-controls, cross-sectional studies, case reports and governmental notices addressing the achievements, the gaps, the challenges and the opportunities towards the 95-95-95 targets in Cameroon. The search will consider studies from 2017 to 2024, retrieved from PubMed/MEDLINE, Cochrane Central Register of Controlled Trials, Google Scholar, online African journals, and Cumulative Index to Nursing and Allied Health Literature. We will include studies reporting HIV diagnosis, HIV link to treatment or HIV viral suppression in Cameroon. Results will be stratified according to time, age-group (adults' vs adolescents/children) and geographic locations. Primary outcomes will be "estimates on 95-95-95 programmatic goals at the national level". Secondary outcomes will consist of the SWOT analysis towards achieving these programmatic targets. A random-effects model will be used to calculate pooled prevalence if data permits.<h4>Conclusions</h4>This systematic review and meta-analysis protocol will guide global estimation on the achievement of the 95-95-95 targets as well as the stakes and challenges within the Cameroonian setting. Final evidence from the systematic review will allow identification of the gaps and measures to be taken to fasten our move towards the 95-95-95 in Cameroon by 2025.<h4>Systematic review registration</h4>Systematic review registration: CRD42024502755. |
| format | Article |
| id | doaj-art-ba5a1b97134e4fd89032553e37575ef0 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-ba5a1b97134e4fd89032553e37575ef02025-08-20T03:25:46ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01202e031785010.1371/journal.pone.0317850Gaps, challenges and opportunities towards achieving the 95-95-95 targets in Cameroon: A systematic review and meta-analysis protocol.Ezechiel Ngoufack Jagni SemengueAlex Durand N K APamela Patricia TueguemChristelle Aude Ka'eEvariste MolimbouLum Yah ForgweiNaomi-Karell EtameAurelie Minelle Kengni NguekoDésiré TakouAristide Stephane Abah AbahAlice KetchadjiPamen BoubaDavid Kob SameOscar EtogoBasile KeugoungAbdelkader BachaPhanuel HabimanaMartin Samuel SossoAlexis NdjoloCarlo-Federico PernoVittorio ColizziRogers AjehAnne-Cecile Z-K BissekNicaise NdembiJoseph Fokam<h4>Background</h4>Given HIV elimination by 2030, the World Health Organization and the United Nations' Programme on HIV/AIDS (UNAIDS) have set three programmatic goals that all countries should have achieved before 2025; 95% of people living with HIV should know their status (target-1); 95% of people who know their status should be linked to treatment (target-2); and 95% of people on treatment should achieve viral load suppression (i.e. VL<1000 copies/ml; target-3). Despite considerable global progress over the past decade, many low-middle-income countries are still below the expected targets. This review protocol aims to provide a standardized document for in-depth analysis of the strengths, weaknesses, opportunities and threats (SWOT) towards achieving these programmatic targets in Cameroon.<h4>Methods</h4>This systematic review will include randomized and non-randomized trials, cohorts, case-controls, cross-sectional studies, case reports and governmental notices addressing the achievements, the gaps, the challenges and the opportunities towards the 95-95-95 targets in Cameroon. The search will consider studies from 2017 to 2024, retrieved from PubMed/MEDLINE, Cochrane Central Register of Controlled Trials, Google Scholar, online African journals, and Cumulative Index to Nursing and Allied Health Literature. We will include studies reporting HIV diagnosis, HIV link to treatment or HIV viral suppression in Cameroon. Results will be stratified according to time, age-group (adults' vs adolescents/children) and geographic locations. Primary outcomes will be "estimates on 95-95-95 programmatic goals at the national level". Secondary outcomes will consist of the SWOT analysis towards achieving these programmatic targets. A random-effects model will be used to calculate pooled prevalence if data permits.<h4>Conclusions</h4>This systematic review and meta-analysis protocol will guide global estimation on the achievement of the 95-95-95 targets as well as the stakes and challenges within the Cameroonian setting. Final evidence from the systematic review will allow identification of the gaps and measures to be taken to fasten our move towards the 95-95-95 in Cameroon by 2025.<h4>Systematic review registration</h4>Systematic review registration: CRD42024502755.https://doi.org/10.1371/journal.pone.0317850 |
| spellingShingle | Ezechiel Ngoufack Jagni Semengue Alex Durand N K A Pamela Patricia Tueguem Christelle Aude Ka'e Evariste Molimbou Lum Yah Forgwei Naomi-Karell Etame Aurelie Minelle Kengni Ngueko Désiré Takou Aristide Stephane Abah Abah Alice Ketchadji Pamen Bouba David Kob Same Oscar Etogo Basile Keugoung Abdelkader Bacha Phanuel Habimana Martin Samuel Sosso Alexis Ndjolo Carlo-Federico Perno Vittorio Colizzi Rogers Ajeh Anne-Cecile Z-K Bissek Nicaise Ndembi Joseph Fokam Gaps, challenges and opportunities towards achieving the 95-95-95 targets in Cameroon: A systematic review and meta-analysis protocol. PLoS ONE |
| title | Gaps, challenges and opportunities towards achieving the 95-95-95 targets in Cameroon: A systematic review and meta-analysis protocol. |
| title_full | Gaps, challenges and opportunities towards achieving the 95-95-95 targets in Cameroon: A systematic review and meta-analysis protocol. |
| title_fullStr | Gaps, challenges and opportunities towards achieving the 95-95-95 targets in Cameroon: A systematic review and meta-analysis protocol. |
| title_full_unstemmed | Gaps, challenges and opportunities towards achieving the 95-95-95 targets in Cameroon: A systematic review and meta-analysis protocol. |
| title_short | Gaps, challenges and opportunities towards achieving the 95-95-95 targets in Cameroon: A systematic review and meta-analysis protocol. |
| title_sort | gaps challenges and opportunities towards achieving the 95 95 95 targets in cameroon a systematic review and meta analysis protocol |
| url | https://doi.org/10.1371/journal.pone.0317850 |
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