Adenosine, Energy Metabolism, and Sleep
While the exact function of sleep remains unknown, it is evident that sleep was developed early in phylogenesis and represents an ancient and vital strategy for survival. Several pieces of evidence suggest that the function of sleep is associated with energy metabolism, saving of energy, and repleni...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2003-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2003.65 |
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| _version_ | 1850176067137961984 |
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| author | Tarja Porkka-Heiskanen Anna Kalinchuk Lauri Alanko Anna Urrila Dag Stenberg |
| author_facet | Tarja Porkka-Heiskanen Anna Kalinchuk Lauri Alanko Anna Urrila Dag Stenberg |
| author_sort | Tarja Porkka-Heiskanen |
| collection | DOAJ |
| description | While the exact function of sleep remains unknown, it is evident that sleep was developed early in phylogenesis and represents an ancient and vital strategy for survival. Several pieces of evidence suggest that the function of sleep is associated with energy metabolism, saving of energy, and replenishment of energy stores. Prolonged wakefulness induces signs of energy depletion in the brain, while experimentally induced, local energy depletion induces increase in sleep, similarly as would a period of prolonged wakefulness. The key molecule in the induction of sleep appears to be adenosine, which induces sleep locally in the basal forebrain. |
| format | Article |
| id | doaj-art-ba55d07e2e5f48e690b28a0afaa1c4ec |
| institution | OA Journals |
| issn | 1537-744X |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-ba55d07e2e5f48e690b28a0afaa1c4ec2025-08-20T02:19:21ZengWileyThe Scientific World Journal1537-744X2003-01-01379079810.1100/tsw.2003.65Adenosine, Energy Metabolism, and SleepTarja Porkka-Heiskanen0Anna Kalinchuk1Lauri Alanko2Anna Urrila3Dag Stenberg4Institute of Biomedicine, University of Helsinki, FinlandInstitute of Biomedicine, University of Helsinki, FinlandInstitute of Biomedicine, University of Helsinki, FinlandInstitute of Biomedicine, University of Helsinki, FinlandInstitute of Biomedicine, University of Helsinki, FinlandWhile the exact function of sleep remains unknown, it is evident that sleep was developed early in phylogenesis and represents an ancient and vital strategy for survival. Several pieces of evidence suggest that the function of sleep is associated with energy metabolism, saving of energy, and replenishment of energy stores. Prolonged wakefulness induces signs of energy depletion in the brain, while experimentally induced, local energy depletion induces increase in sleep, similarly as would a period of prolonged wakefulness. The key molecule in the induction of sleep appears to be adenosine, which induces sleep locally in the basal forebrain.http://dx.doi.org/10.1100/tsw.2003.65 |
| spellingShingle | Tarja Porkka-Heiskanen Anna Kalinchuk Lauri Alanko Anna Urrila Dag Stenberg Adenosine, Energy Metabolism, and Sleep The Scientific World Journal |
| title | Adenosine, Energy Metabolism, and Sleep |
| title_full | Adenosine, Energy Metabolism, and Sleep |
| title_fullStr | Adenosine, Energy Metabolism, and Sleep |
| title_full_unstemmed | Adenosine, Energy Metabolism, and Sleep |
| title_short | Adenosine, Energy Metabolism, and Sleep |
| title_sort | adenosine energy metabolism and sleep |
| url | http://dx.doi.org/10.1100/tsw.2003.65 |
| work_keys_str_mv | AT tarjaporkkaheiskanen adenosineenergymetabolismandsleep AT annakalinchuk adenosineenergymetabolismandsleep AT laurialanko adenosineenergymetabolismandsleep AT annaurrila adenosineenergymetabolismandsleep AT dagstenberg adenosineenergymetabolismandsleep |