Pediatric Plastic Bronchitis: Case Report and Retrospective Comparative Analysis of Epidemiology and Pathology
Plastic bronchitis (PB) is a pathologic condition in which airway casts develop in the tracheobronchial tree causing airway obstruction. There is no standard treatment strategy for this uncommon condition. We report an index patient treated using an emerging multimodal strategy of directly instille...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Case Reports in Pulmonology |
| Online Access: | http://dx.doi.org/10.1155/2013/649365 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565054336139264 |
|---|---|
| author | Rebecca Kunder Christian Kunder Heather Y. Sun Gerald Berry Anna Messner Jennifer Frankovich Stephen Roth John Mark |
| author_facet | Rebecca Kunder Christian Kunder Heather Y. Sun Gerald Berry Anna Messner Jennifer Frankovich Stephen Roth John Mark |
| author_sort | Rebecca Kunder |
| collection | DOAJ |
| description | Plastic bronchitis (PB) is a pathologic condition in which airway casts develop in the tracheobronchial tree causing airway obstruction. There is no standard treatment strategy for this uncommon condition. We report an index patient treated using an emerging multimodal strategy of directly instilled and inhaled tissue plasminogen activator (t-PA) as well as 13 other cases of PB at our institution between 2000 and 2012. The majority of cases (n=8) occurred in patients with congenital heart disease. Clinical presentations, treatments used, histopathology of the casts, and patient outcomes are reviewed. Further discussion is focused on the epidemiology of plastic bronchitis and a systematic approach to the histologic classification of casts. Comorbid conditions identified in this study included congenital heart disease (8), pneumonia (3), and asthma (2). Our institutional prevalence rate was 6.8 per 100,000 patients, and our case fatality rate was 7%. |
| format | Article |
| id | doaj-art-ba517a95168d47088a73c23179809dc8 |
| institution | Kabale University |
| issn | 2090-6846 2090-6854 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pulmonology |
| spelling | doaj-art-ba517a95168d47088a73c23179809dc82025-02-03T01:09:30ZengWileyCase Reports in Pulmonology2090-68462090-68542013-01-01201310.1155/2013/649365649365Pediatric Plastic Bronchitis: Case Report and Retrospective Comparative Analysis of Epidemiology and PathologyRebecca Kunder0Christian Kunder1Heather Y. Sun2Gerald Berry3Anna Messner4Jennifer Frankovich5Stephen Roth6John Mark7Departments of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USADepartments of Pathology, Stanford University School of Medicine, Palo Alto, CA, USADepartments of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USADepartments of Pathology, Stanford University School of Medicine, Palo Alto, CA, USADepartments of Otolaryngology, Head & Neck Surgery, Stanford University School of Medicine, Palo Alto, CA, USADepartments of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USADepartments of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USADepartments of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USAPlastic bronchitis (PB) is a pathologic condition in which airway casts develop in the tracheobronchial tree causing airway obstruction. There is no standard treatment strategy for this uncommon condition. We report an index patient treated using an emerging multimodal strategy of directly instilled and inhaled tissue plasminogen activator (t-PA) as well as 13 other cases of PB at our institution between 2000 and 2012. The majority of cases (n=8) occurred in patients with congenital heart disease. Clinical presentations, treatments used, histopathology of the casts, and patient outcomes are reviewed. Further discussion is focused on the epidemiology of plastic bronchitis and a systematic approach to the histologic classification of casts. Comorbid conditions identified in this study included congenital heart disease (8), pneumonia (3), and asthma (2). Our institutional prevalence rate was 6.8 per 100,000 patients, and our case fatality rate was 7%.http://dx.doi.org/10.1155/2013/649365 |
| spellingShingle | Rebecca Kunder Christian Kunder Heather Y. Sun Gerald Berry Anna Messner Jennifer Frankovich Stephen Roth John Mark Pediatric Plastic Bronchitis: Case Report and Retrospective Comparative Analysis of Epidemiology and Pathology Case Reports in Pulmonology |
| title | Pediatric Plastic Bronchitis: Case Report and Retrospective Comparative Analysis of Epidemiology and Pathology |
| title_full | Pediatric Plastic Bronchitis: Case Report and Retrospective Comparative Analysis of Epidemiology and Pathology |
| title_fullStr | Pediatric Plastic Bronchitis: Case Report and Retrospective Comparative Analysis of Epidemiology and Pathology |
| title_full_unstemmed | Pediatric Plastic Bronchitis: Case Report and Retrospective Comparative Analysis of Epidemiology and Pathology |
| title_short | Pediatric Plastic Bronchitis: Case Report and Retrospective Comparative Analysis of Epidemiology and Pathology |
| title_sort | pediatric plastic bronchitis case report and retrospective comparative analysis of epidemiology and pathology |
| url | http://dx.doi.org/10.1155/2013/649365 |
| work_keys_str_mv | AT rebeccakunder pediatricplasticbronchitiscasereportandretrospectivecomparativeanalysisofepidemiologyandpathology AT christiankunder pediatricplasticbronchitiscasereportandretrospectivecomparativeanalysisofepidemiologyandpathology AT heatherysun pediatricplasticbronchitiscasereportandretrospectivecomparativeanalysisofepidemiologyandpathology AT geraldberry pediatricplasticbronchitiscasereportandretrospectivecomparativeanalysisofepidemiologyandpathology AT annamessner pediatricplasticbronchitiscasereportandretrospectivecomparativeanalysisofepidemiologyandpathology AT jenniferfrankovich pediatricplasticbronchitiscasereportandretrospectivecomparativeanalysisofepidemiologyandpathology AT stephenroth pediatricplasticbronchitiscasereportandretrospectivecomparativeanalysisofepidemiologyandpathology AT johnmark pediatricplasticbronchitiscasereportandretrospectivecomparativeanalysisofepidemiologyandpathology |