Changes in the neurological status from 30 to 90 days post-cardiac arrest by age: A nationwide retrospective observational study
Introduction: Few studies have investigated the changes in the neurological status after 30 days post-arrest in out-of-hospital cardiac arrest (OHCA) patients according to the patient age. The aim of this study was to investigate the differences in the mid-term (from 30 days to 90 days) neurological...
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Elsevier
2025-03-01
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| Series: | Resuscitation Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666520425000542 |
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| author | Hiromi Miyoshi Mitsuaki Nishikimi Kazuya Kikutani Shinichiro Ohshimo Nobuaki Shime |
| author_facet | Hiromi Miyoshi Mitsuaki Nishikimi Kazuya Kikutani Shinichiro Ohshimo Nobuaki Shime |
| author_sort | Hiromi Miyoshi |
| collection | DOAJ |
| description | Introduction: Few studies have investigated the changes in the neurological status after 30 days post-arrest in out-of-hospital cardiac arrest (OHCA) patients according to the patient age. The aim of this study was to investigate the differences in the mid-term (from 30 days to 90 days) neurological changes after CA according to the age group. Methods: We retrospectively analysed the data of all OHCA patients aged ≥1 year who showed return of spontaneous circulation and survived until 30 days after CA. We compared the proportions of patients who showed neurological deterioration from 30 to 90 days post-CA by age group (1–17, 18–39, 40–64, 65–79, ≥80 years). The neurological outcome was assessed by the Cerebral Performance Category (CPC) or Pediatric Cerebral Performance Category (PCPC) scale. Results: Of the 68,110 registered patients, we analysed the data of a total of 2,663 patients. The neurological deterioration rate and improvement rate from 30 to 90 days after CA in each age group were as follows: 1–17 years: 11.6% (8/69)/7.2% (5/69); 18–39 years: 8.3% (15/181)/6.1% (11/181); 40–64 years: 7.3% (72/982)/7.0% (69/982); 65–79 years: 13.5% (130/965)/8.1% (78/965); and ≥ 80 years: 24.2% (113/466)/4.9% (23/466). Multivariable logistic regression analysis showed a higher likelihood of mid-term neurological deterioration in patients aged ≥ 80 years than in those aged 1–17 years. Conclusions: Most OHCA patients, irrespective of age, showed no change of the neurological status from 30 to 90 days after OHCA. However, a relatively large percentage of patients aged ≥80 years old showed significant neurological deterioration after 30 days post-OHCA. |
| format | Article |
| id | doaj-art-ba511e94b17b4b2fb0273cf12f3ce689 |
| institution | OA Journals |
| issn | 2666-5204 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
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| series | Resuscitation Plus |
| spelling | doaj-art-ba511e94b17b4b2fb0273cf12f3ce6892025-08-20T02:07:19ZengElsevierResuscitation Plus2666-52042025-03-012210091710.1016/j.resplu.2025.100917Changes in the neurological status from 30 to 90 days post-cardiac arrest by age: A nationwide retrospective observational studyHiromi Miyoshi0Mitsuaki Nishikimi1Kazuya Kikutani2Shinichiro Ohshimo3Nobuaki Shime4Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, JapanCorresponding author at: 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.; Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, JapanDepartment of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, JapanDepartment of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, JapanDepartment of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, JapanIntroduction: Few studies have investigated the changes in the neurological status after 30 days post-arrest in out-of-hospital cardiac arrest (OHCA) patients according to the patient age. The aim of this study was to investigate the differences in the mid-term (from 30 days to 90 days) neurological changes after CA according to the age group. Methods: We retrospectively analysed the data of all OHCA patients aged ≥1 year who showed return of spontaneous circulation and survived until 30 days after CA. We compared the proportions of patients who showed neurological deterioration from 30 to 90 days post-CA by age group (1–17, 18–39, 40–64, 65–79, ≥80 years). The neurological outcome was assessed by the Cerebral Performance Category (CPC) or Pediatric Cerebral Performance Category (PCPC) scale. Results: Of the 68,110 registered patients, we analysed the data of a total of 2,663 patients. The neurological deterioration rate and improvement rate from 30 to 90 days after CA in each age group were as follows: 1–17 years: 11.6% (8/69)/7.2% (5/69); 18–39 years: 8.3% (15/181)/6.1% (11/181); 40–64 years: 7.3% (72/982)/7.0% (69/982); 65–79 years: 13.5% (130/965)/8.1% (78/965); and ≥ 80 years: 24.2% (113/466)/4.9% (23/466). Multivariable logistic regression analysis showed a higher likelihood of mid-term neurological deterioration in patients aged ≥ 80 years than in those aged 1–17 years. Conclusions: Most OHCA patients, irrespective of age, showed no change of the neurological status from 30 to 90 days after OHCA. However, a relatively large percentage of patients aged ≥80 years old showed significant neurological deterioration after 30 days post-OHCA.http://www.sciencedirect.com/science/article/pii/S2666520425000542Post-cardiac arrest syndromeNeurological prognosisMid-term neurological changesAgeOut-of-hospital cardiac arrest |
| spellingShingle | Hiromi Miyoshi Mitsuaki Nishikimi Kazuya Kikutani Shinichiro Ohshimo Nobuaki Shime Changes in the neurological status from 30 to 90 days post-cardiac arrest by age: A nationwide retrospective observational study Resuscitation Plus Post-cardiac arrest syndrome Neurological prognosis Mid-term neurological changes Age Out-of-hospital cardiac arrest |
| title | Changes in the neurological status from 30 to 90 days post-cardiac arrest by age: A nationwide retrospective observational study |
| title_full | Changes in the neurological status from 30 to 90 days post-cardiac arrest by age: A nationwide retrospective observational study |
| title_fullStr | Changes in the neurological status from 30 to 90 days post-cardiac arrest by age: A nationwide retrospective observational study |
| title_full_unstemmed | Changes in the neurological status from 30 to 90 days post-cardiac arrest by age: A nationwide retrospective observational study |
| title_short | Changes in the neurological status from 30 to 90 days post-cardiac arrest by age: A nationwide retrospective observational study |
| title_sort | changes in the neurological status from 30 to 90 days post cardiac arrest by age a nationwide retrospective observational study |
| topic | Post-cardiac arrest syndrome Neurological prognosis Mid-term neurological changes Age Out-of-hospital cardiac arrest |
| url | http://www.sciencedirect.com/science/article/pii/S2666520425000542 |
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