Recent advances in Polygonatum sibiricum polysaccharides: structural insights, bioactivities in Vitro and in Vivo, and therapeutic potential in human and animal models – A review
Polygonatum sibiricum polysaccharides (PSPs) have attracted increasing attention due to their diverse biological activities and broad therapeutic potential. This review is presented as a comprehensive narrative review, based on a structured analysis of peer-reviewed literature published between 2000...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | Carbohydrate Polymer Technologies and Applications |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666893925002993 |
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| author | Mohamed E. Abd El-Hack Hassan A. Rudayni Ahmed K Aldhalmi Abdullah S. Alawam Ahmed A. Allam Mohammad M.H. Khan Asmaa F. Khafaga |
| author_facet | Mohamed E. Abd El-Hack Hassan A. Rudayni Ahmed K Aldhalmi Abdullah S. Alawam Ahmed A. Allam Mohammad M.H. Khan Asmaa F. Khafaga |
| author_sort | Mohamed E. Abd El-Hack |
| collection | DOAJ |
| description | Polygonatum sibiricum polysaccharides (PSPs) have attracted increasing attention due to their diverse biological activities and broad therapeutic potential. This review is presented as a comprehensive narrative review, based on a structured analysis of peer-reviewed literature published between 2000 and 2025, sourced from databases including PubMed, Web of Science, and Scopus. It summarizes recent advances in the structural characterization, extraction technologies, and bioactivities of PSPs based on both in vitro and in vivo studies. Various extraction methods such as hot water extraction, ultrasound-assisted extraction, enzyme-assisted extraction (using cellulase and papain), radiation-assisted extraction, and green solvents like natural deep eutectic solvents (NADESs) and CO₂-triggered hydrophilic solvents are critically compared. Quantitative data from optimized conditions show PSP yields ranging from 4.4 % (hot water) to 29.7 % (NADES-based extraction). Structural features including monosaccharide composition, glycosidic linkages, and molecular weight distribution are discussed in relation to pharmacological functions. PSPs demonstrate promising antioxidant, immunomodulatory, anti-diabetic, anti-obesity, hepatoprotective, and anti-tumoral effects. Clinical relevance is supported by evidence of improved immune response, glucose regulation, and lipid metabolism in preclinical disease models. Furthermore, PSPs hold potential for applications in the pharmaceutical, nutraceutical, and functional food industries due to their biocompatibility and therapeutic value. In conclusion, this review highlights the need for standardized extraction protocols, deeper investigations into structure activity relationships, and translational clinical research to advance the biomedical and industrial applications of PSPs. |
| format | Article |
| id | doaj-art-ba50ad221cc942e4a71a6009fd496b4c |
| institution | Kabale University |
| issn | 2666-8939 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Carbohydrate Polymer Technologies and Applications |
| spelling | doaj-art-ba50ad221cc942e4a71a6009fd496b4c2025-08-20T03:59:37ZengElsevierCarbohydrate Polymer Technologies and Applications2666-89392025-09-011110095810.1016/j.carpta.2025.100958Recent advances in Polygonatum sibiricum polysaccharides: structural insights, bioactivities in Vitro and in Vivo, and therapeutic potential in human and animal models – A reviewMohamed E. Abd El-Hack0Hassan A. Rudayni1Ahmed K Aldhalmi2Abdullah S. Alawam3Ahmed A. Allam4Mohammad M.H. Khan5Asmaa F. Khafaga6Department of Industrial Pharmacy, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology (MUST), P.O. Box 77, Giza, Egypt; Corresponding authors.Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi ArabiaCollege of Pharmacy, Al- Mustaqbal University, 51001 Babylon, IraqDepartment of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi ArabiaDepartment of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi ArabiaDepartment of Biochemistry and Chemistry, Faculty of Biotechnology and Genetic Engineering, Sylhet Agricultural University, 3100 Sylhet, Bangladesh; Corresponding authors.Department of Pathology, Faculty of Veterinary Medicine, Alexandria University, Alexandria-APIs 21944, EgyptPolygonatum sibiricum polysaccharides (PSPs) have attracted increasing attention due to their diverse biological activities and broad therapeutic potential. This review is presented as a comprehensive narrative review, based on a structured analysis of peer-reviewed literature published between 2000 and 2025, sourced from databases including PubMed, Web of Science, and Scopus. It summarizes recent advances in the structural characterization, extraction technologies, and bioactivities of PSPs based on both in vitro and in vivo studies. Various extraction methods such as hot water extraction, ultrasound-assisted extraction, enzyme-assisted extraction (using cellulase and papain), radiation-assisted extraction, and green solvents like natural deep eutectic solvents (NADESs) and CO₂-triggered hydrophilic solvents are critically compared. Quantitative data from optimized conditions show PSP yields ranging from 4.4 % (hot water) to 29.7 % (NADES-based extraction). Structural features including monosaccharide composition, glycosidic linkages, and molecular weight distribution are discussed in relation to pharmacological functions. PSPs demonstrate promising antioxidant, immunomodulatory, anti-diabetic, anti-obesity, hepatoprotective, and anti-tumoral effects. Clinical relevance is supported by evidence of improved immune response, glucose regulation, and lipid metabolism in preclinical disease models. Furthermore, PSPs hold potential for applications in the pharmaceutical, nutraceutical, and functional food industries due to their biocompatibility and therapeutic value. In conclusion, this review highlights the need for standardized extraction protocols, deeper investigations into structure activity relationships, and translational clinical research to advance the biomedical and industrial applications of PSPs.http://www.sciencedirect.com/science/article/pii/S2666893925002993Polygonatum sibiricum polysaccharidesExtraction techniquesStructural characterizationBiological activitiesPharmacological potentialImmune modulation |
| spellingShingle | Mohamed E. Abd El-Hack Hassan A. Rudayni Ahmed K Aldhalmi Abdullah S. Alawam Ahmed A. Allam Mohammad M.H. Khan Asmaa F. Khafaga Recent advances in Polygonatum sibiricum polysaccharides: structural insights, bioactivities in Vitro and in Vivo, and therapeutic potential in human and animal models – A review Carbohydrate Polymer Technologies and Applications Polygonatum sibiricum polysaccharides Extraction techniques Structural characterization Biological activities Pharmacological potential Immune modulation |
| title | Recent advances in Polygonatum sibiricum polysaccharides: structural insights, bioactivities in Vitro and in Vivo, and therapeutic potential in human and animal models – A review |
| title_full | Recent advances in Polygonatum sibiricum polysaccharides: structural insights, bioactivities in Vitro and in Vivo, and therapeutic potential in human and animal models – A review |
| title_fullStr | Recent advances in Polygonatum sibiricum polysaccharides: structural insights, bioactivities in Vitro and in Vivo, and therapeutic potential in human and animal models – A review |
| title_full_unstemmed | Recent advances in Polygonatum sibiricum polysaccharides: structural insights, bioactivities in Vitro and in Vivo, and therapeutic potential in human and animal models – A review |
| title_short | Recent advances in Polygonatum sibiricum polysaccharides: structural insights, bioactivities in Vitro and in Vivo, and therapeutic potential in human and animal models – A review |
| title_sort | recent advances in polygonatum sibiricum polysaccharides structural insights bioactivities in vitro and in vivo and therapeutic potential in human and animal models a review |
| topic | Polygonatum sibiricum polysaccharides Extraction techniques Structural characterization Biological activities Pharmacological potential Immune modulation |
| url | http://www.sciencedirect.com/science/article/pii/S2666893925002993 |
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