Correlation between the Frequency of Th17 Cell and the Expression of MicroRNA-206 in Patients with Dermatomyositis
It was reported that IL-17 had been detected in the inflammatory infiltrates of patients with DM (dermatomyositis). In this study, we investigated the frequency of Th17 cells and the expression of microRNA-206 (miR-206) in DM patients. Firstly, we observed that the frequency of Th17 cells and the ex...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/345347 |
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| author | Xinyi Tang Xinyu Tian Yue Zhang Wei Wu Jie Tian Ke Rui Jia Tong Liwei Lu Huaxi Xu Shengjun Wang |
| author_facet | Xinyi Tang Xinyu Tian Yue Zhang Wei Wu Jie Tian Ke Rui Jia Tong Liwei Lu Huaxi Xu Shengjun Wang |
| author_sort | Xinyi Tang |
| collection | DOAJ |
| description | It was reported that IL-17 had been detected in the inflammatory infiltrates of patients with DM (dermatomyositis). In this study, we investigated the frequency of Th17 cells and the expression of microRNA-206 (miR-206) in DM patients. Firstly, we observed that the frequency of Th17 cells and the expression of transcription factors were increased significantly in the PBMCs of DM patients. Secondly, we found that there was a positive correlation between the percentages of Th17 cells and serum level of CK in DM patients. And the serum concentrations of IL-6, IL-1β, TGF-β, and IL-23, the important cytokines of Th17 differentiation, were increased in DM patients. It was predicted that Krüppel-like factor 4 (KLF4) is one of the multiple targets of miR-206. We detected the expression of miR-206 in DM patients, and it was decreased in the serum and PBMCs of DM patients. The augmented expression of KLF is accompanied by the attenuated expression of miR-206. Furthermore, a negative correlation between the percentages of Th17 cells and the expression of miR-206 in DM patients has been found. Taken together, these findings suggest the attenuated expression of miR-206, and the augmented frequency of Th17 cells in DM patients. |
| format | Article |
| id | doaj-art-ba4e47366e3840ed9c670aee22a30fef |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-ba4e47366e3840ed9c670aee22a30fef2025-02-03T01:00:26ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/345347345347Correlation between the Frequency of Th17 Cell and the Expression of MicroRNA-206 in Patients with DermatomyositisXinyi Tang0Xinyu Tian1Yue Zhang2Wei Wu3Jie Tian4Ke Rui5Jia Tong6Liwei Lu7Huaxi Xu8Shengjun Wang9Department of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University School of Medical Science and Laboratory Medicine, Zhenjiang 212013, ChinaDepartment of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University School of Medical Science and Laboratory Medicine, Zhenjiang 212013, ChinaDepartment of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University School of Medical Science and Laboratory Medicine, Zhenjiang 212013, ChinaDepartment of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University School of Medical Science and Laboratory Medicine, Zhenjiang 212013, ChinaDepartment of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University School of Medical Science and Laboratory Medicine, Zhenjiang 212013, ChinaDepartment of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University School of Medical Science and Laboratory Medicine, Zhenjiang 212013, ChinaDepartment of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University School of Medical Science and Laboratory Medicine, Zhenjiang 212013, ChinaDepartment of Pathology and Centre of Infection and Immunology, The University of Hong Kong, Hong KongDepartment of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University School of Medical Science and Laboratory Medicine, Zhenjiang 212013, ChinaDepartment of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University School of Medical Science and Laboratory Medicine, Zhenjiang 212013, ChinaIt was reported that IL-17 had been detected in the inflammatory infiltrates of patients with DM (dermatomyositis). In this study, we investigated the frequency of Th17 cells and the expression of microRNA-206 (miR-206) in DM patients. Firstly, we observed that the frequency of Th17 cells and the expression of transcription factors were increased significantly in the PBMCs of DM patients. Secondly, we found that there was a positive correlation between the percentages of Th17 cells and serum level of CK in DM patients. And the serum concentrations of IL-6, IL-1β, TGF-β, and IL-23, the important cytokines of Th17 differentiation, were increased in DM patients. It was predicted that Krüppel-like factor 4 (KLF4) is one of the multiple targets of miR-206. We detected the expression of miR-206 in DM patients, and it was decreased in the serum and PBMCs of DM patients. The augmented expression of KLF is accompanied by the attenuated expression of miR-206. Furthermore, a negative correlation between the percentages of Th17 cells and the expression of miR-206 in DM patients has been found. Taken together, these findings suggest the attenuated expression of miR-206, and the augmented frequency of Th17 cells in DM patients.http://dx.doi.org/10.1155/2013/345347 |
| spellingShingle | Xinyi Tang Xinyu Tian Yue Zhang Wei Wu Jie Tian Ke Rui Jia Tong Liwei Lu Huaxi Xu Shengjun Wang Correlation between the Frequency of Th17 Cell and the Expression of MicroRNA-206 in Patients with Dermatomyositis Clinical and Developmental Immunology |
| title | Correlation between the Frequency of Th17 Cell and the Expression of MicroRNA-206 in Patients with Dermatomyositis |
| title_full | Correlation between the Frequency of Th17 Cell and the Expression of MicroRNA-206 in Patients with Dermatomyositis |
| title_fullStr | Correlation between the Frequency of Th17 Cell and the Expression of MicroRNA-206 in Patients with Dermatomyositis |
| title_full_unstemmed | Correlation between the Frequency of Th17 Cell and the Expression of MicroRNA-206 in Patients with Dermatomyositis |
| title_short | Correlation between the Frequency of Th17 Cell and the Expression of MicroRNA-206 in Patients with Dermatomyositis |
| title_sort | correlation between the frequency of th17 cell and the expression of microrna 206 in patients with dermatomyositis |
| url | http://dx.doi.org/10.1155/2013/345347 |
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