Chinese herbal medicine (Bu-Shen-Tian-Jing Formula) for outcomes of IVF in Chinese patients with polycystic ovary syndrome: A retrospective cohort study
Background: Polycystic ovary syndrome (PCOS) is one of the most common causes of anovulatory infertility. Chinese herbal medicine (CHM) has many advantages in treating PCOS. We conducted a retrospective cohort study to investigate the effects of CHM (Bu-Shen-Tian-Jing Formula, BSTJF) on the outcomes...
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Elsevier
2022-03-01
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| Series: | Integrative Medicine Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213422021000627 |
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| author | Xiaoming Pan Yinger Gu Xian Zhang Biwei Shi Long Cui Fangfang Wang Fan Qu |
| author_facet | Xiaoming Pan Yinger Gu Xian Zhang Biwei Shi Long Cui Fangfang Wang Fan Qu |
| author_sort | Xiaoming Pan |
| collection | DOAJ |
| description | Background: Polycystic ovary syndrome (PCOS) is one of the most common causes of anovulatory infertility. Chinese herbal medicine (CHM) has many advantages in treating PCOS. We conducted a retrospective cohort study to investigate the effects of CHM (Bu-Shen-Tian-Jing Formula, BSTJF) on the outcomes of IVF in Chinese patients with PCOS and the potential underlying mechanism. Methods: A total of 111 patients with PCOS who undergone IVF between November 2009 and July 2018 were included. Fifty-four patients received a three-month BSTJF therapy before controlled ovarian hyperstimulation, while the other 57 patients didn't. The data of the PCOS patients was collected. Anti-Müllerian hormone (AMH), growth differentiation factor-8 (GDF-8) levels in the follicular fluid were evaluated. Results: BSTJF helped patients with PCOS to get more retrieved oocytes (P<0.05) and fertilized oocytes (P<0.05). The clinical cumulative pregnancy rate, live birth rate, and term delivery rate were significantly higher in the same stimulated cycle of the PCOS patients with BSTJF treatment (P<0.05). No significant differences existed between the two groups in the rate of fertilization, hospitalization rate of ovarian hyper stimulation syndrome and obstetrical or neonatal complications. BSTJF significantly decreased the AMH levels in the follicular fluids (P<0.05). Conclusion: BSTJF significantly may improve the outcomes of IVF in Chinese patients with PCOS through decreasing AMH levels in follicular fluids. However, the evidence is limited due to the small sample size and the several potential bias. |
| format | Article |
| id | doaj-art-ba485f4173694f0db6da000087b42bda |
| institution | DOAJ |
| issn | 2213-4220 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Integrative Medicine Research |
| spelling | doaj-art-ba485f4173694f0db6da000087b42bda2025-08-20T03:23:30ZengElsevierIntegrative Medicine Research2213-42202022-03-0111110077510.1016/j.imr.2021.100775Chinese herbal medicine (Bu-Shen-Tian-Jing Formula) for outcomes of IVF in Chinese patients with polycystic ovary syndrome: A retrospective cohort studyXiaoming Pan0Yinger Gu1Xian Zhang2Biwei Shi3Long Cui4Fangfang Wang5Fan Qu6Women's Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaWomen's Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaWomen's Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaWomen's Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaWomen's Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaWomen's Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaWomen's Hospital, Zhejiang University School of Medicine, Hangzhou, China; Corresponding author at: Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou 310006, China.Background: Polycystic ovary syndrome (PCOS) is one of the most common causes of anovulatory infertility. Chinese herbal medicine (CHM) has many advantages in treating PCOS. We conducted a retrospective cohort study to investigate the effects of CHM (Bu-Shen-Tian-Jing Formula, BSTJF) on the outcomes of IVF in Chinese patients with PCOS and the potential underlying mechanism. Methods: A total of 111 patients with PCOS who undergone IVF between November 2009 and July 2018 were included. Fifty-four patients received a three-month BSTJF therapy before controlled ovarian hyperstimulation, while the other 57 patients didn't. The data of the PCOS patients was collected. Anti-Müllerian hormone (AMH), growth differentiation factor-8 (GDF-8) levels in the follicular fluid were evaluated. Results: BSTJF helped patients with PCOS to get more retrieved oocytes (P<0.05) and fertilized oocytes (P<0.05). The clinical cumulative pregnancy rate, live birth rate, and term delivery rate were significantly higher in the same stimulated cycle of the PCOS patients with BSTJF treatment (P<0.05). No significant differences existed between the two groups in the rate of fertilization, hospitalization rate of ovarian hyper stimulation syndrome and obstetrical or neonatal complications. BSTJF significantly decreased the AMH levels in the follicular fluids (P<0.05). Conclusion: BSTJF significantly may improve the outcomes of IVF in Chinese patients with PCOS through decreasing AMH levels in follicular fluids. However, the evidence is limited due to the small sample size and the several potential bias.http://www.sciencedirect.com/science/article/pii/S2213422021000627Anti-Müllerian hormoneChinese herbal medicinegrowth differentiation factor-8in vitro fertilizationpolycystic ovary syndrome |
| spellingShingle | Xiaoming Pan Yinger Gu Xian Zhang Biwei Shi Long Cui Fangfang Wang Fan Qu Chinese herbal medicine (Bu-Shen-Tian-Jing Formula) for outcomes of IVF in Chinese patients with polycystic ovary syndrome: A retrospective cohort study Integrative Medicine Research Anti-Müllerian hormone Chinese herbal medicine growth differentiation factor-8 in vitro fertilization polycystic ovary syndrome |
| title | Chinese herbal medicine (Bu-Shen-Tian-Jing Formula) for outcomes of IVF in Chinese patients with polycystic ovary syndrome: A retrospective cohort study |
| title_full | Chinese herbal medicine (Bu-Shen-Tian-Jing Formula) for outcomes of IVF in Chinese patients with polycystic ovary syndrome: A retrospective cohort study |
| title_fullStr | Chinese herbal medicine (Bu-Shen-Tian-Jing Formula) for outcomes of IVF in Chinese patients with polycystic ovary syndrome: A retrospective cohort study |
| title_full_unstemmed | Chinese herbal medicine (Bu-Shen-Tian-Jing Formula) for outcomes of IVF in Chinese patients with polycystic ovary syndrome: A retrospective cohort study |
| title_short | Chinese herbal medicine (Bu-Shen-Tian-Jing Formula) for outcomes of IVF in Chinese patients with polycystic ovary syndrome: A retrospective cohort study |
| title_sort | chinese herbal medicine bu shen tian jing formula for outcomes of ivf in chinese patients with polycystic ovary syndrome a retrospective cohort study |
| topic | Anti-Müllerian hormone Chinese herbal medicine growth differentiation factor-8 in vitro fertilization polycystic ovary syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S2213422021000627 |
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