Efficacy and safety of 5-aminolevulinic acid photodynamic therapy in refractory genital lichen sclerosus
Background: Genital lichen sclerosus (GLS) is a chronic inflammatory skin disease affecting the genital and anal areas. Treatment of refractory remains a challenge in clinical practice. Objective: This study aimed to evaluate the efficacy and safety of 5-aminolevulinic acid photodynamic therapy (5-A...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Photodiagnosis and Photodynamic Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100024004757 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832575543582654464 |
|---|---|
| author | Weiwei Shi Fang Wang Liangliang Chen Ruzhi Zhang |
| author_facet | Weiwei Shi Fang Wang Liangliang Chen Ruzhi Zhang |
| author_sort | Weiwei Shi |
| collection | DOAJ |
| description | Background: Genital lichen sclerosus (GLS) is a chronic inflammatory skin disease affecting the genital and anal areas. Treatment of refractory remains a challenge in clinical practice. Objective: This study aimed to evaluate the efficacy and safety of 5-aminolevulinic acid photodynamic therapy (5-ALA PDT) for refractory GLS. Methods: Thirty-five patients with histopathologically confirmed GLS (including 32 females and 3 males) were treated with 5-ALA PDT. Lesion pretreatment was performed to enhance photosensitizer penetration, and fluorescence diagnosis was used for precise point-to-point treatment. Efficacy and safety were systematically evaluated by assessing treatment outcomes, symptom improvement, side effects and maintenance of efficacy over a 6-month follow-up period. Results: After treatment, most patients experienced significant relief of pruritus, improved skin elasticity and color, and reduced lesion area. After 6 treatment sessions, 11 patients (31.43 %) achieved complete resolution of pruritus, with 3 patients (8.57 %) achieving complete remission after 3 sessions. Cattaneo scores decreased significantly after treatment and during follow-up (P < 0.05). Adverse reactions were mainly mild pain, which could be relieved by ice compression or oral analgesics. Conclusions: 5-ALA PDT shows significant efficacy and good safety for refractory GLS, improving the clinical symptoms and signs of patients, and warrants wider clinical application. |
| format | Article |
| id | doaj-art-ba484b4f8b854c6b9126a17d44c7852d |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-ba484b4f8b854c6b9126a17d44c7852d2025-02-01T04:11:42ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-02-0151104439Efficacy and safety of 5-aminolevulinic acid photodynamic therapy in refractory genital lichen sclerosusWeiwei Shi0Fang Wang1Liangliang Chen2Ruzhi Zhang3Department of Dermatology, Affiliated Hospital 2 of Nantong University, Nantong, 226000, China; Department of Dermatology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, ChinaDepartment of Dermatology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, ChinaDepartment of Dermatology, The Second Affiliated Hospital of Wannan Medical College, Wuhu, 241000, ChinaDepartment of Dermatology, The Second Affiliated Hospital of Wannan Medical College, Wuhu, 241000, China; Corresponding author at: Department of Dermatology, The Second Affiliated Hospital of Wannan Medical College, 10 Kangfu Road, Wuhu, 241000, China.Background: Genital lichen sclerosus (GLS) is a chronic inflammatory skin disease affecting the genital and anal areas. Treatment of refractory remains a challenge in clinical practice. Objective: This study aimed to evaluate the efficacy and safety of 5-aminolevulinic acid photodynamic therapy (5-ALA PDT) for refractory GLS. Methods: Thirty-five patients with histopathologically confirmed GLS (including 32 females and 3 males) were treated with 5-ALA PDT. Lesion pretreatment was performed to enhance photosensitizer penetration, and fluorescence diagnosis was used for precise point-to-point treatment. Efficacy and safety were systematically evaluated by assessing treatment outcomes, symptom improvement, side effects and maintenance of efficacy over a 6-month follow-up period. Results: After treatment, most patients experienced significant relief of pruritus, improved skin elasticity and color, and reduced lesion area. After 6 treatment sessions, 11 patients (31.43 %) achieved complete resolution of pruritus, with 3 patients (8.57 %) achieving complete remission after 3 sessions. Cattaneo scores decreased significantly after treatment and during follow-up (P < 0.05). Adverse reactions were mainly mild pain, which could be relieved by ice compression or oral analgesics. Conclusions: 5-ALA PDT shows significant efficacy and good safety for refractory GLS, improving the clinical symptoms and signs of patients, and warrants wider clinical application.http://www.sciencedirect.com/science/article/pii/S1572100024004757Lichen sclerosusGenital area5-Aminolevulinic acidPhotodynamic therapy |
| spellingShingle | Weiwei Shi Fang Wang Liangliang Chen Ruzhi Zhang Efficacy and safety of 5-aminolevulinic acid photodynamic therapy in refractory genital lichen sclerosus Photodiagnosis and Photodynamic Therapy Lichen sclerosus Genital area 5-Aminolevulinic acid Photodynamic therapy |
| title | Efficacy and safety of 5-aminolevulinic acid photodynamic therapy in refractory genital lichen sclerosus |
| title_full | Efficacy and safety of 5-aminolevulinic acid photodynamic therapy in refractory genital lichen sclerosus |
| title_fullStr | Efficacy and safety of 5-aminolevulinic acid photodynamic therapy in refractory genital lichen sclerosus |
| title_full_unstemmed | Efficacy and safety of 5-aminolevulinic acid photodynamic therapy in refractory genital lichen sclerosus |
| title_short | Efficacy and safety of 5-aminolevulinic acid photodynamic therapy in refractory genital lichen sclerosus |
| title_sort | efficacy and safety of 5 aminolevulinic acid photodynamic therapy in refractory genital lichen sclerosus |
| topic | Lichen sclerosus Genital area 5-Aminolevulinic acid Photodynamic therapy |
| url | http://www.sciencedirect.com/science/article/pii/S1572100024004757 |
| work_keys_str_mv | AT weiweishi efficacyandsafetyof5aminolevulinicacidphotodynamictherapyinrefractorygenitallichensclerosus AT fangwang efficacyandsafetyof5aminolevulinicacidphotodynamictherapyinrefractorygenitallichensclerosus AT liangliangchen efficacyandsafetyof5aminolevulinicacidphotodynamictherapyinrefractorygenitallichensclerosus AT ruzhizhang efficacyandsafetyof5aminolevulinicacidphotodynamictherapyinrefractorygenitallichensclerosus |