Global burden of polycystic ovary syndrome, uterine cancer and diabetes mellitus type 2 among women of childbearing age: trends in incidence, prevalence, mortality, and disability-adjusted life-years from 1990 to 2021
BackgroundPolycystic ovary syndrome (PCOS), uterine cancer, and type 2 diabetes mellitus (T2DM) are major health concerns for women of childbearing age (WCBA), with complex pathogenesis and significant global burden. Understanding their epidemiological trends and risk factors is critical for public...
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Frontiers Media S.A.
2025-07-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1628462/full |
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| author | Ming Zhu Xie MaoHua Qin ZhaoJun Yang RongXia Huang Rong Qin |
| author_facet | Ming Zhu Xie MaoHua Qin ZhaoJun Yang RongXia Huang Rong Qin |
| author_sort | Ming Zhu Xie |
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| description | BackgroundPolycystic ovary syndrome (PCOS), uterine cancer, and type 2 diabetes mellitus (T2DM) are major health concerns for women of childbearing age (WCBA), with complex pathogenesis and significant global burden. Understanding their epidemiological trends and risk factors is critical for public health planning.MethodsData from the Global Burden of Disease (GBD) 2021 database were analyzed to assess the burden of PCOS, uterine cancer, and T2DM across 204 countries and territories from 1990 to 2021. Age-standardized rates of prevalence, mortality, disability-adjusted life-years (DALYs), and estimated annual percentage changes (EAPCs) were evaluated. Risk factor contributions, including high body mass index (BMI) and metabolic risks, were also examined.ResultsIn 2021, T2DM had the highest age-standardized incidence rate (267.85 per 100,000), followed by PCOS (64.44) and uterine cancer (2.87). From 1990 to 2021, T2DM incidence rose most significantly, while PCOS and uterine cancer also showed increasing trends. High BMI contributed to 30.76% of uterine cancer deaths and 62.87% of T2DM deaths, whereas metabolic risks accounted for 100% of T2DM deaths.ConclusionThe rising global burden of PCOS, uterine cancer, and T2DM underscores a pressing public health challenge. Prioritizing healthy lifestyles in high-burden regions and fostering international collaboration are essential to mitigate these trends. |
| format | Article |
| id | doaj-art-ba47a04f77b340e7b4cc25378152cf13 |
| institution | OA Journals |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj-art-ba47a04f77b340e7b4cc25378152cf132025-08-20T02:35:56ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-07-011210.3389/fmed.2025.16284621628462Global burden of polycystic ovary syndrome, uterine cancer and diabetes mellitus type 2 among women of childbearing age: trends in incidence, prevalence, mortality, and disability-adjusted life-years from 1990 to 2021Ming Zhu Xie0MaoHua Qin1ZhaoJun Yang2RongXia Huang3Rong Qin4Department of Gynecology, Kunming Maternity and Child Care Hospital, Kunming, Yunnan, ChinaDepartment of Gynecology, Kunming Maternity and Child Care Hospital, Kunming, Yunnan, ChinaDepartment of Gynecology, Kunming Maternity and Child Care Hospital, Kunming, Yunnan, ChinaDepartment of Gynecology, Kunming Maternity and Child Care Hospital, Kunming, Yunnan, ChinaDepartment of Gastroenterology, Yan’an Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, ChinaBackgroundPolycystic ovary syndrome (PCOS), uterine cancer, and type 2 diabetes mellitus (T2DM) are major health concerns for women of childbearing age (WCBA), with complex pathogenesis and significant global burden. Understanding their epidemiological trends and risk factors is critical for public health planning.MethodsData from the Global Burden of Disease (GBD) 2021 database were analyzed to assess the burden of PCOS, uterine cancer, and T2DM across 204 countries and territories from 1990 to 2021. Age-standardized rates of prevalence, mortality, disability-adjusted life-years (DALYs), and estimated annual percentage changes (EAPCs) were evaluated. Risk factor contributions, including high body mass index (BMI) and metabolic risks, were also examined.ResultsIn 2021, T2DM had the highest age-standardized incidence rate (267.85 per 100,000), followed by PCOS (64.44) and uterine cancer (2.87). From 1990 to 2021, T2DM incidence rose most significantly, while PCOS and uterine cancer also showed increasing trends. High BMI contributed to 30.76% of uterine cancer deaths and 62.87% of T2DM deaths, whereas metabolic risks accounted for 100% of T2DM deaths.ConclusionThe rising global burden of PCOS, uterine cancer, and T2DM underscores a pressing public health challenge. Prioritizing healthy lifestyles in high-burden regions and fostering international collaboration are essential to mitigate these trends.https://www.frontiersin.org/articles/10.3389/fmed.2025.1628462/fullpolycystic ovary syndromeuterine cancertype 2 diabetes mellitusglobal burden of diseasewomen of childbearing agesocioeconomic development |
| spellingShingle | Ming Zhu Xie MaoHua Qin ZhaoJun Yang RongXia Huang Rong Qin Global burden of polycystic ovary syndrome, uterine cancer and diabetes mellitus type 2 among women of childbearing age: trends in incidence, prevalence, mortality, and disability-adjusted life-years from 1990 to 2021 Frontiers in Medicine polycystic ovary syndrome uterine cancer type 2 diabetes mellitus global burden of disease women of childbearing age socioeconomic development |
| title | Global burden of polycystic ovary syndrome, uterine cancer and diabetes mellitus type 2 among women of childbearing age: trends in incidence, prevalence, mortality, and disability-adjusted life-years from 1990 to 2021 |
| title_full | Global burden of polycystic ovary syndrome, uterine cancer and diabetes mellitus type 2 among women of childbearing age: trends in incidence, prevalence, mortality, and disability-adjusted life-years from 1990 to 2021 |
| title_fullStr | Global burden of polycystic ovary syndrome, uterine cancer and diabetes mellitus type 2 among women of childbearing age: trends in incidence, prevalence, mortality, and disability-adjusted life-years from 1990 to 2021 |
| title_full_unstemmed | Global burden of polycystic ovary syndrome, uterine cancer and diabetes mellitus type 2 among women of childbearing age: trends in incidence, prevalence, mortality, and disability-adjusted life-years from 1990 to 2021 |
| title_short | Global burden of polycystic ovary syndrome, uterine cancer and diabetes mellitus type 2 among women of childbearing age: trends in incidence, prevalence, mortality, and disability-adjusted life-years from 1990 to 2021 |
| title_sort | global burden of polycystic ovary syndrome uterine cancer and diabetes mellitus type 2 among women of childbearing age trends in incidence prevalence mortality and disability adjusted life years from 1990 to 2021 |
| topic | polycystic ovary syndrome uterine cancer type 2 diabetes mellitus global burden of disease women of childbearing age socioeconomic development |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1628462/full |
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