Azobenzene as Multi-Targeted Scaffold in Medicinal Chemistry
The discovery of a multi-target scaffold in medicinal chemistry is an important goal for the development of new drugs with different biological effects. Azobenzene is one of the frameworks in medicinal chemistry used for its simple synthetic methods and for the possibility to obtain a great variety...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/29/24/5872 |
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| author | Barbara De Filippis Alice Della Valle Alessandra Ammazzalorso Cristina Maccallini Giuseppe Tesse Rosa Amoroso Adriano Mollica Letizia Giampietro |
| author_facet | Barbara De Filippis Alice Della Valle Alessandra Ammazzalorso Cristina Maccallini Giuseppe Tesse Rosa Amoroso Adriano Mollica Letizia Giampietro |
| author_sort | Barbara De Filippis |
| collection | DOAJ |
| description | The discovery of a multi-target scaffold in medicinal chemistry is an important goal for the development of new drugs with different biological effects. Azobenzene is one of the frameworks in medicinal chemistry used for its simple synthetic methods and for the possibility to obtain a great variety of derivatives by simple chemical modifications or substitutions. Phenyldiazenyl-containing compounds show a wide spectrum of pharmacological activities, such as antimicrobial, anti-inflammatory, anti-neurodegenerative, anti-cancer, and anti-enzymatic. The aim of this review is to highlight the importance of azobenzene as a scaffold in medicinal chemistry, with particular attention to the chemical modifications and structure–activity relationships (SARs). This review emphasizes the main therapeutic applications of phenyldiazenyl derivatives, with a particular focus on structural modification and its influence on activity, with the aim of inspiring medicinal chemists to obtain new, increasingly powerful azobenzenes useful in therapy. |
| format | Article |
| id | doaj-art-ba3d348889db4e808fbdd31428ab3d4a |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-ba3d348889db4e808fbdd31428ab3d4a2024-12-27T14:42:30ZengMDPI AGMolecules1420-30492024-12-012924587210.3390/molecules29245872Azobenzene as Multi-Targeted Scaffold in Medicinal ChemistryBarbara De Filippis0Alice Della Valle1Alessandra Ammazzalorso2Cristina Maccallini3Giuseppe Tesse4Rosa Amoroso5Adriano Mollica6Letizia Giampietro7Department of Pharmacy, University “G. d’Annunzio”, 66100 Chieti, ItalyDepartment of Pharmacy, University “G. d’Annunzio”, 66100 Chieti, ItalyDepartment of Pharmacy, University “G. d’Annunzio”, 66100 Chieti, ItalyDepartment of Pharmacy, University “G. d’Annunzio”, 66100 Chieti, ItalyDepartment of Pharmacy, University “G. d’Annunzio”, 66100 Chieti, ItalyDepartment of Pharmacy, University “G. d’Annunzio”, 66100 Chieti, ItalyDepartment of Pharmacy, University “G. d’Annunzio”, 66100 Chieti, ItalyDepartment of Pharmacy, University “G. d’Annunzio”, 66100 Chieti, ItalyThe discovery of a multi-target scaffold in medicinal chemistry is an important goal for the development of new drugs with different biological effects. Azobenzene is one of the frameworks in medicinal chemistry used for its simple synthetic methods and for the possibility to obtain a great variety of derivatives by simple chemical modifications or substitutions. Phenyldiazenyl-containing compounds show a wide spectrum of pharmacological activities, such as antimicrobial, anti-inflammatory, anti-neurodegenerative, anti-cancer, and anti-enzymatic. The aim of this review is to highlight the importance of azobenzene as a scaffold in medicinal chemistry, with particular attention to the chemical modifications and structure–activity relationships (SARs). This review emphasizes the main therapeutic applications of phenyldiazenyl derivatives, with a particular focus on structural modification and its influence on activity, with the aim of inspiring medicinal chemists to obtain new, increasingly powerful azobenzenes useful in therapy.https://www.mdpi.com/1420-3049/29/24/5872azobenzeneazo-compoundsmulti-targetphenyldiazenylphenylazo moiety |
| spellingShingle | Barbara De Filippis Alice Della Valle Alessandra Ammazzalorso Cristina Maccallini Giuseppe Tesse Rosa Amoroso Adriano Mollica Letizia Giampietro Azobenzene as Multi-Targeted Scaffold in Medicinal Chemistry Molecules azobenzene azo-compounds multi-target phenyldiazenyl phenylazo moiety |
| title | Azobenzene as Multi-Targeted Scaffold in Medicinal Chemistry |
| title_full | Azobenzene as Multi-Targeted Scaffold in Medicinal Chemistry |
| title_fullStr | Azobenzene as Multi-Targeted Scaffold in Medicinal Chemistry |
| title_full_unstemmed | Azobenzene as Multi-Targeted Scaffold in Medicinal Chemistry |
| title_short | Azobenzene as Multi-Targeted Scaffold in Medicinal Chemistry |
| title_sort | azobenzene as multi targeted scaffold in medicinal chemistry |
| topic | azobenzene azo-compounds multi-target phenyldiazenyl phenylazo moiety |
| url | https://www.mdpi.com/1420-3049/29/24/5872 |
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