FTO downregulation-mediated m6A modification resulting in enhanced hepatocellular carcinoma invasion

FTO downregulation-mediated m6A modification resulting in enhanced hepatocellular carcinoma invasion

Abstract Background Dysregulation of N6-methyladenosine (m6A) modifications has been implicated in various cancers, including hepatocellular carcinoma (HCC). This study aimed to elucidate the role of m6A modifications in HCC prognosis and the molecular mechanisms involved, particularly focusing on t...

Full description

Saved in:

Bibliographic Details
Main Authors:	Cheng Zhou, Yong Zhang, Shi-Ming Shi, Dan Yin, Xue-Dong Li, Ying-Hong Shi, Jian Zhou, Zheng Wang, Qing Chen
Format:	Article
Language:	English
Published:	BMC 2025-05-01
Series:	Cell & Bioscience
Subjects:	Hepatocellular carcinoma Fat mass and obesity-associated protein N6-methyladenosine VEGFA
Online Access:	https://doi.org/10.1186/s13578-025-01395-w
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Depletion of Fat Mass and Obesity‐Associated Protein (FTO) Drives Heterochromatin Loss via Lysine Acetyltransferase 8 (KAT8)‐Mediated Remodeling and Spacing Factor 1 (RSF1) Acetylation in Skin Aging
by: Fan Wang, et al.
Published: (2025-07-01)

m6A-modified CTC-297N7.9 inhibits hepatocellular carcinoma metastasis via epigenetically downregulating CCL2 and CD47
by: Huamei Wei, et al.
Published: (2025-07-01)

The Role of Fat Mass and Obesity-Associated (FTO) Gene in Non-Small Cell Lung Cancer Tumorigenicity and EGFR Tyrosine Kinase Inhibitor Resistance
by: Aayush Rastogi, et al.
Published: (2025-07-01)

m6A-Methylated NUTM2B-AS1 Promotes Hepatocellular Carcinoma Stemness Feature via Epigenetically Activating BMPR1A Transcription
by: Li W, et al.
Published: (2024-12-01)

Ginsenoside Rb1 mitigates atherosclerosis in part through modulating FTO-mediated m6A RNA modification in NETs-induced endothelial activation
by: Zhenni Yang, et al.
Published: (2025-07-01)

Discovery of a potent PROTAC degrader for RNA demethylase FTO as antileukemic therapy
by: Lu Liu, et al.
Published: (2024-12-01)

circFTO binding with IGF2BP2 regulates trophoblast cells proliferation, migration, and invasion while mediating m6A modification of CCAR1 mRNA in spontaneous abortion
by: Yiwen Zhang, et al.
Published: (2025-07-01)

New insights into N6-methyladenosine in hepatocellular carcinoma immunotherapy
by: Mengran Li, et al.
Published: (2025-01-01)

Cinobufagin inhibits hepatocellular carcinoma EMT-like stemness via VEGF/VEGFR2 autocrine signaling
by: Mingjun Ye, et al.
Published: (2025-05-01)

m6A2Circ: A comprehensive database for decoding the regulatory relationship between m6A modification and circular RNA
by: Yongtian Li, et al.
Published: (2025-01-01)

The role of N(6)-methyladenosine (m6a) modification in cancer
by: Xiaozhou Xie, et al.
Published: (2025-01-01)

Repurposing FDA-approved drugs to find a novel inhibitor of alpha-ketoglutarate-dependent dioxygenase FTO to treat esophageal cancer
by: Zeinab Mohammadi, et al.
Published: (2025-05-01)

Omics-based evaluation of m6A modification patterns in uveal melanoma and their prognostic implications
by: Xiaohui Shi, et al.
Published: (2025-03-01)

Fat mass and obesity–mediated N6-methyladenosine modification modulates neuroinflammatory responses after traumatic brain injury
by: Xiangrong Chen, et al.
Published: (2026-02-01)

Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy
by: Xue Chen, et al.
Published: (2024-01-01)

m6A modification: a novel mechanism that regulates atherosclerosis via macrophage polarization
by: Xiaying Li, et al.
Published: (2025-06-01)

The Correlation Analysis Between m6A Methylation Modification and Ferroptosis Induced by Cigarette Smoke in Human Bronchial Epithelium
by: Xiaomei Duan, et al.
Published: (2024-12-01)

M6A Demethyltransferase FTO Attenuates Meniscus Degeneration and Osteoarthritis via Orchestrating Autophagy and Energetic Metabolism
by: Zongrui Jiang, et al.
Published: (2025-03-01)

FTO deficiency facilitates epithelia dysfunction in oral lichen planus
by: Yufeng Fan, et al.
Published: (2025-03-01)

m6A modification of RNA in cervical cancer: role and clinical perspectives
by: Yajuan Gao, et al.
Published: (2024-12-01)

RNA Modification in Metabolism
by: Yadi Liu, et al.
Published: (2025-03-01)

O-GlcNAcylated FTO promotes m6A modification of SOX4 to enhance MDS/AML cell proliferation
by: Junjie Gou, et al.
Published: (2025-01-01)

Targeting m<sup>6</sup>A RNA Modification in Tumor Therapeutics
by: Zhenwei Mao, et al.
Published: (2025-03-01)

m6A-lncRNA landscape highlights reduced levels of m6A modification in glioblastoma as compared to low-grade glioma
by: Giedrius Steponaitis, et al.
Published: (2025-05-01)

Injecting structure-aware insights for the learning of RNA sequence representations to identify m6A modification sites
by: Yue Yu, et al.
Published: (2025-02-01)

METTL3 facilitates the progression of cervical cancer by m6A modification-mediated up-regulation of NEK2
by: Yilin Guo, et al.
Published: (2024-10-01)

RNA Modifications in Pathogenic Viruses: Existence, Mechanism, and Impacts
by: Yingying Zou, et al.
Published: (2024-11-01)

WTAP/YTHDF1-mediated m6A modification amplifies IFN-γ-induced immunosuppressive properties of human MSCs
by: Quan Chen, et al.
Published: (2025-05-01)

METTL16 Contributes to Coronary Heart Disease by Inducing TET2 m6A Modification
by: Ruan R, et al.
Published: (2025-05-01)

HHLA2 activates c-Met and identifies patients for targeted therapy in hepatocellular carcinoma
by: Xubo Huang, et al.
Published: (2025-05-01)

Summary of the mechanism of ferroptosis regulated by m6A modification in cancer progression
by: Bin Fan, et al.
Published: (2025-04-01)

The m6A revolution: transforming tumor immunity and enhancing immunotherapy outcomes
by: Tongguo Shi, et al.
Published: (2025-02-01)

METTL3 mediates m6A methylation modification of ULBP2 and affects the progression of cervical cancer
by: Hongtao Ren, et al.
Published: (2025-07-01)

FTO facilitates colorectal cancer chemoresistance via regulation of NUPR1-dependent iron homeostasis
by: Changwei Xu, et al.
Published: (2025-06-01)

FTO-mediated demethylation of MTUS1/ATIP1 promotes tumor progression in head and neck squamous cell carcinoma
by: Dongxiao Tang, et al.
Published: (2024-12-01)

Differential expression and functional analysis of circular RNAs and m6A modifications in children with Philadelphia chromosome-positive acute lymphoblastic leukemia
by: Lichun Xie, et al.
Published: (2025-04-01)

Association of anthropometric indices with rs9939609 FTO gene polymorphism among overweight/obese women with breast cancer: a case-control study
by: Huma Naqeeb, et al.
Published: (2025-06-01)

Recent Advances in the Mutual Regulation of m6A Modification and Non-Coding RNAs in Atherosclerosis
by: Wang Y, et al.
Published: (2025-02-01)

FTO in health and disease
by: Daniel Benak, et al.
Published: (2024-12-01)

Regulatory mechanisms of m6A RNA methylation in esophageal cancer: a comprehensive review
by: Long Wen, et al.
Published: (2025-04-01)