l-carnitine protects against bile acid-induced mitochondrial dysfunction and IGF-1 impairment in hepatocyte cultures

l-carnitine protects against bile acid-induced mitochondrial dysfunction and IGF-1 impairment in hepatocyte cultures

Background and aims: Excessive amounts of bile acids (ΒΑ) exert hepatotoxic effects. We investigated the effects of glycochenodeoxycholic acid (GCDC) on mitochondrial function and insulin-like growth factor-1 (IGF-1) activity in hepatocytes and also examined if l-carnitine (CRNT) has any protective...

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Bibliographic Details
Main Authors: Wafa'a Alqabandi, Maira Alsaeid, Gursev Dhaunsi
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Endocrine and Metabolic Science
Subjects:
Mitochondria IGF-1
Carnitine
Bile acids
Hepatocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S2666396125000354
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