Integrated transcriptome profiling and in vitro analysis reveals MLN4924’s role in inducing ferroptosis in acute myeloid leukemia

Integrated transcriptome profiling and in vitro analysis reveals MLN4924’s role in inducing ferroptosis in acute myeloid leukemia

Objectives: While ferroptosis induction emerges as a therapeutic strategy for solid tumors, its role in acute myeloid leukemia (AML) remains unexplored. This study aimed to investigate the role of MLN4924 in modulating ferroptosis and its molecular targets in AML.Methods: Transcriptome sequencing an...

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Bibliographic Details
Main Authors: Jinli Jian, Yuancheng Guo, Xiao Tang, Long Zhao, Bei Liu
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Hematology
Subjects:
MLN4924
SLC7A11
GPX4
ferroptosis
acute myeloid leukemia
Online Access:https://www.tandfonline.com/doi/10.1080/16078454.2025.2497041
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