Differences in Clinical Characteristics and Brain Activity between Patients with Low- and High-Frequency Tinnitus
This study was aimed at delineating and comparing differences in clinical characteristics and brain activity between patients with low- and high-frequency tinnitus (LFT and HFT, respectively) using high-density electroencephalography (EEG). This study enrolled 3217 patients with subjective tinnitus...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2020/5285362 |
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| author | Jiajia Zhang Zhen Zhang Shujian Huang Huiqun Zhou Yanmei Feng Haibo Shi Dan Wang Wenya Nan Hui Wang Shankai Yin |
| author_facet | Jiajia Zhang Zhen Zhang Shujian Huang Huiqun Zhou Yanmei Feng Haibo Shi Dan Wang Wenya Nan Hui Wang Shankai Yin |
| author_sort | Jiajia Zhang |
| collection | DOAJ |
| description | This study was aimed at delineating and comparing differences in clinical characteristics and brain activity between patients with low- and high-frequency tinnitus (LFT and HFT, respectively) using high-density electroencephalography (EEG). This study enrolled 3217 patients with subjective tinnitus who were divided into LFT (frequency<4000 Hz) and HFT (≥4000 Hz) groups. Data regarding medical history, Tinnitus Handicap Inventory, tinnitus matching, and hearing threshold were collected from all patients. Twenty tinnitus patients and 20 volunteers were subjected to 256-channel EEG, and neurophysiological differences were evaluated using standardized low-resolution brain electromagnetic tomography (sLORETA) source-localized EEG recordings. Significant differences in sex (p<0.001), age (p=0.022), laterality (p<0.001), intensity (p<0.001), tinnitus type (p<0.001), persistent tinnitus (p=0.04), average threshold (p<0.001), and hearing loss (p=0.028) were observed between LFT and HFT groups. The tinnitus pitch only appeared to be correlated with the threshold of the worst hearing loss in the HFT group. Compared with the controls, the LFT group exhibited increased gamma power (p<0.05), predominantly in the posterior cingulate cortex (PCC, BA31), whereas the HFT group had significantly decreased alpha1 power (p<0.05) in the angular gyrus (BA39) and auditory association cortex (BA22). Higher gamma linear connectivity between right BA39 and right BA41 was observed in the HFT group relative to controls (t=3.637, p=0.027). Significant changes associated with increased gamma in the LFT group and decreased alpha1 in the HFT group indicate that tinnitus pitch is crucial for matching between the tinnitus and control groups. Differences of band frequency energy in brain activity levels may contribute to the clinical characteristics and internal tinnitus “spectrum” differences. |
| format | Article |
| id | doaj-art-ba38afda5911408db0e8e2317c9f13aa |
| institution | DOAJ |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-ba38afda5911408db0e8e2317c9f13aa2025-08-20T03:23:26ZengWileyNeural Plasticity2090-59041687-54432020-01-01202010.1155/2020/52853625285362Differences in Clinical Characteristics and Brain Activity between Patients with Low- and High-Frequency TinnitusJiajia Zhang0Zhen Zhang1Shujian Huang2Huiqun Zhou3Yanmei Feng4Haibo Shi5Dan Wang6Wenya Nan7Hui Wang8Shankai Yin9Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai 200233, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai 200233, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai 200233, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai 200233, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai 200233, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai 200233, ChinaDepartment of Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, ChinaDepartment of Psychology, Shanghai Normal University, Shanghai 200233, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai 200233, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai 200233, ChinaThis study was aimed at delineating and comparing differences in clinical characteristics and brain activity between patients with low- and high-frequency tinnitus (LFT and HFT, respectively) using high-density electroencephalography (EEG). This study enrolled 3217 patients with subjective tinnitus who were divided into LFT (frequency<4000 Hz) and HFT (≥4000 Hz) groups. Data regarding medical history, Tinnitus Handicap Inventory, tinnitus matching, and hearing threshold were collected from all patients. Twenty tinnitus patients and 20 volunteers were subjected to 256-channel EEG, and neurophysiological differences were evaluated using standardized low-resolution brain electromagnetic tomography (sLORETA) source-localized EEG recordings. Significant differences in sex (p<0.001), age (p=0.022), laterality (p<0.001), intensity (p<0.001), tinnitus type (p<0.001), persistent tinnitus (p=0.04), average threshold (p<0.001), and hearing loss (p=0.028) were observed between LFT and HFT groups. The tinnitus pitch only appeared to be correlated with the threshold of the worst hearing loss in the HFT group. Compared with the controls, the LFT group exhibited increased gamma power (p<0.05), predominantly in the posterior cingulate cortex (PCC, BA31), whereas the HFT group had significantly decreased alpha1 power (p<0.05) in the angular gyrus (BA39) and auditory association cortex (BA22). Higher gamma linear connectivity between right BA39 and right BA41 was observed in the HFT group relative to controls (t=3.637, p=0.027). Significant changes associated with increased gamma in the LFT group and decreased alpha1 in the HFT group indicate that tinnitus pitch is crucial for matching between the tinnitus and control groups. Differences of band frequency energy in brain activity levels may contribute to the clinical characteristics and internal tinnitus “spectrum” differences.http://dx.doi.org/10.1155/2020/5285362 |
| spellingShingle | Jiajia Zhang Zhen Zhang Shujian Huang Huiqun Zhou Yanmei Feng Haibo Shi Dan Wang Wenya Nan Hui Wang Shankai Yin Differences in Clinical Characteristics and Brain Activity between Patients with Low- and High-Frequency Tinnitus Neural Plasticity |
| title | Differences in Clinical Characteristics and Brain Activity between Patients with Low- and High-Frequency Tinnitus |
| title_full | Differences in Clinical Characteristics and Brain Activity between Patients with Low- and High-Frequency Tinnitus |
| title_fullStr | Differences in Clinical Characteristics and Brain Activity between Patients with Low- and High-Frequency Tinnitus |
| title_full_unstemmed | Differences in Clinical Characteristics and Brain Activity between Patients with Low- and High-Frequency Tinnitus |
| title_short | Differences in Clinical Characteristics and Brain Activity between Patients with Low- and High-Frequency Tinnitus |
| title_sort | differences in clinical characteristics and brain activity between patients with low and high frequency tinnitus |
| url | http://dx.doi.org/10.1155/2020/5285362 |
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