DrugBERT: a BERT-based approach integrating LDA topic embedding and efficacy-aware mechanism for predicting anti-tumor drug efficacy

DrugBERT: a BERT-based approach integrating LDA topic embedding and efficacy-aware mechanism for predicting anti-tumor drug efficacy

Abstract Background Due to the complexity of tumor genetic heterogeneity, personalized medicine has progressively emerged as the central focus of cancer research. However, how to accurately predict the drug response of patients before receiving treatment is the critical challenge to the development...

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Bibliographic Details
Main Authors: Weiwei Zhu, Xiaodong Jiang, Lei Zhang, Peng Zhou, Xinping Xie, Hongqiang Wang
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Translational Medicine
Subjects:
Drug efficacy prediction
LDA topic embedding
BERT
Self-attention mechanism
Clinical text data
Online Access:https://doi.org/10.1186/s12967-025-06795-7
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