Role of FTO in Adipocyte Development and Function: Recent Insights
In 2007, FTO was identified as the first genome-wide association study (GWAS) gene associated with obesity in humans. Since then, various animal models have served to establish the mechanistic basis behind this association. Many earlier studies focussed on FTO’s effects on food intake via central me...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/521381 |
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| _version_ | 1832562558126522368 |
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| author | Myrte Merkestein Dyan Sellayah |
| author_facet | Myrte Merkestein Dyan Sellayah |
| author_sort | Myrte Merkestein |
| collection | DOAJ |
| description | In 2007, FTO was identified as the first genome-wide association study (GWAS) gene associated with obesity in humans. Since then, various animal models have served to establish the mechanistic basis behind this association. Many earlier studies focussed on FTO’s effects on food intake via central mechanisms. Emerging evidence, however, implicates adipose tissue development and function in the causal relationship between perturbations in FTO expression and obesity. The purpose of this mini review is to shed light on these new studies of FTO function in adipose tissue and present a clearer picture of its impact on obesity susceptibility. |
| format | Article |
| id | doaj-art-ba2da114b69940c990116f4d52c19501 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-ba2da114b69940c990116f4d52c195012025-02-03T01:22:23ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/521381521381Role of FTO in Adipocyte Development and Function: Recent InsightsMyrte Merkestein0Dyan Sellayah1Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, Oxfordshire OX1 3PT, UKSchool of Biological Sciences, University of Reading, Reading, Berkshire RG6 6AS, UKIn 2007, FTO was identified as the first genome-wide association study (GWAS) gene associated with obesity in humans. Since then, various animal models have served to establish the mechanistic basis behind this association. Many earlier studies focussed on FTO’s effects on food intake via central mechanisms. Emerging evidence, however, implicates adipose tissue development and function in the causal relationship between perturbations in FTO expression and obesity. The purpose of this mini review is to shed light on these new studies of FTO function in adipose tissue and present a clearer picture of its impact on obesity susceptibility.http://dx.doi.org/10.1155/2015/521381 |
| spellingShingle | Myrte Merkestein Dyan Sellayah Role of FTO in Adipocyte Development and Function: Recent Insights International Journal of Endocrinology |
| title | Role of FTO in Adipocyte Development and Function: Recent Insights |
| title_full | Role of FTO in Adipocyte Development and Function: Recent Insights |
| title_fullStr | Role of FTO in Adipocyte Development and Function: Recent Insights |
| title_full_unstemmed | Role of FTO in Adipocyte Development and Function: Recent Insights |
| title_short | Role of FTO in Adipocyte Development and Function: Recent Insights |
| title_sort | role of fto in adipocyte development and function recent insights |
| url | http://dx.doi.org/10.1155/2015/521381 |
| work_keys_str_mv | AT myrtemerkestein roleofftoinadipocytedevelopmentandfunctionrecentinsights AT dyansellayah roleofftoinadipocytedevelopmentandfunctionrecentinsights |