Challenges and updates in the management of eosinophilic esophagitis
Eosinophilic esophagitis (EE) is a chronic T helper cell-2 mediated inflammatory condition and is considered as a primary cause of dysphagia and foregut symptoms. There are many challenges regarding the treatment options of EE. Different therapeutic approaches are best at meeting different endpoints...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2019-04-01
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| Series: | Gastroenterology Review |
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| Online Access: | https://www.termedia.pl/Challenges-and-updates-in-the-management-r-nof-eosinophilic-esophagitis,41,36396,1,1.html |
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| _version_ | 1841548430017560576 |
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| author | Tsvetelina Velikova |
| author_facet | Tsvetelina Velikova |
| author_sort | Tsvetelina Velikova |
| collection | DOAJ |
| description | Eosinophilic esophagitis (EE) is a chronic T helper cell-2 mediated inflammatory condition and is considered as a primary cause of dysphagia and foregut symptoms. There are many challenges regarding the treatment options of EE. Different therapeutic approaches are best at meeting different endpoints. There are unresolved questions such as whether the goal for treatment should be to control esophageal eosinophilia and inflammation or to achieve symptomatic improvement. Still, proton pump inhibitors are used in differential diagnosis, along with their anti-inflammatory and anti-acid properties. Conducted trials continue to recommend the use of topical corticosteroids and empiric food elimination diets as first-line therapeutic modalities. The growing knowledge on the pathogenesis of EE has allowed further progression of encouraging targeted biologic therapies. However, the guidelines for EE management should be updated accordingly in the coming years, including fast evolving data on non-invasive diagnostic strategies, new treatment modalities, and the long-term prognosis of the disease. |
| format | Article |
| id | doaj-art-ba2d09d8803e4d809ef2ba7d14a245bb |
| institution | Kabale University |
| issn | 1895-5770 1897-4317 |
| language | English |
| publishDate | 2019-04-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Gastroenterology Review |
| spelling | doaj-art-ba2d09d8803e4d809ef2ba7d14a245bb2025-01-10T14:06:15ZengTermedia Publishing HouseGastroenterology Review1895-57701897-43172019-04-01151273310.5114/pg.2019.8447636396Challenges and updates in the management of eosinophilic esophagitisTsvetelina VelikovaEosinophilic esophagitis (EE) is a chronic T helper cell-2 mediated inflammatory condition and is considered as a primary cause of dysphagia and foregut symptoms. There are many challenges regarding the treatment options of EE. Different therapeutic approaches are best at meeting different endpoints. There are unresolved questions such as whether the goal for treatment should be to control esophageal eosinophilia and inflammation or to achieve symptomatic improvement. Still, proton pump inhibitors are used in differential diagnosis, along with their anti-inflammatory and anti-acid properties. Conducted trials continue to recommend the use of topical corticosteroids and empiric food elimination diets as first-line therapeutic modalities. The growing knowledge on the pathogenesis of EE has allowed further progression of encouraging targeted biologic therapies. However, the guidelines for EE management should be updated accordingly in the coming years, including fast evolving data on non-invasive diagnostic strategies, new treatment modalities, and the long-term prognosis of the disease.https://www.termedia.pl/Challenges-and-updates-in-the-management-r-nof-eosinophilic-esophagitis,41,36396,1,1.htmlesophagitis eosinophilia diet corticosteroids esophageal dilatation |
| spellingShingle | Tsvetelina Velikova Challenges and updates in the management of eosinophilic esophagitis Gastroenterology Review esophagitis eosinophilia diet corticosteroids esophageal dilatation |
| title | Challenges and updates in the management
of eosinophilic esophagitis |
| title_full | Challenges and updates in the management
of eosinophilic esophagitis |
| title_fullStr | Challenges and updates in the management
of eosinophilic esophagitis |
| title_full_unstemmed | Challenges and updates in the management
of eosinophilic esophagitis |
| title_short | Challenges and updates in the management
of eosinophilic esophagitis |
| title_sort | challenges and updates in the management of eosinophilic esophagitis |
| topic | esophagitis eosinophilia diet corticosteroids esophageal dilatation |
| url | https://www.termedia.pl/Challenges-and-updates-in-the-management-r-nof-eosinophilic-esophagitis,41,36396,1,1.html |
| work_keys_str_mv | AT tsvetelinavelikova challengesandupdatesinthemanagementofeosinophilicesophagitis |